Ayurvedic Medicine Zinc <i>Bhasma</i>: Physicochemical Evaluation, Anti-Diabetic Activity and Safety Assessment

Umrani, Rinku D; Paknikar, Kishore M.

doi:10.1166/jbn.2011.1243

Cited by 18 publications

(16 citation statements)

References 4 publications

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“…The role of the Bhasma in arresting myopia has been examined in one study. [33] Contamination of Bhasmas directly through the herbs used in the preparation and formation of polycyclic aromatic hydrocarbons (PAHs) is expected. Bhasmas were analyzed and found to contain PAH (2.32-9.55 ppm) among the preparation tested.…”

Section: Preparation Of Bhasmamentioning

confidence: 99%

Bhasma : The ancient Indian nanomedicine

Pal

Sahu

Haldar

2014

J Adv Pharm Technol Res

161

102

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Ayurveda and other Indian system of medicine use metals, but their use is also amply described in Chinese and Egyptian civilization in 2500 B.C. Bhasma are unique ayurvedic metallic/minerals preparation, treated with herbal juice or decoction and exposed for Ayurveda, which are known in Indian subcontinent since 7th century A.D. and widely recommended for treatment of a variety of chronic ailments. Animal's derivative such as horns, shells, feathers, metallic, nonmetallic and herbals are normally administered as Bhasma. A Bhasma means an ash obtained through incineration; the starter material undergoes an elaborate process of purification and this process is followed by the reaction phase, which involves incorporation of some other minerals and/or herbal extract. There are various importance of Bhasma like maintaining optimum alkalinity for optimum health, neutralizing harmful acids that lead to illness; because Bhasma do not get metabolized so they don’t produce any harmful metabolite, rather it breakdowns heavy metals in the body. Methods including for Bhasma preparation are parpati, rasayoga, sindora, etc., Bhasma which contain Fe, Cu, S or other manufacturing process plays a specific role in the final product(s). Particle size (1-2 μ) reduced significantly, which may facilitate absorption and assimilation of the drug into the body system. Standardization of Bhasma is utmost necessary to confirm its identity and to determine its quality, purity safety, effectiveness and acceptability of the product. But the most important challenges faced by these formulations are the lack of complete standardization by physiochemical parameters.

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Section: Preparation Of Bhasmamentioning

confidence: 99%

Bhasma : The ancient Indian nanomedicine

Pal

Sahu

Haldar

2014

J Adv Pharm Technol Res

161

102

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“…12 A comprehensive physico-chemical characterization of Jasada Bhasma by Bhowmick et al reveals the presence of ZnO nanoparticles (NPs). 13 These ZnO NPs present in Jasada Bhasma are predominantly of wurzite crystal structure and contains a considerable amount of oxygen deficiency.…”

Section: Introductionmentioning

confidence: 99%

Surface defect rich ZnO quantum dots as antioxidants inhibiting α-amylase and α-glucosidase: a potential anti-diabetic nanomedicine

Asok

Ghosh

et al. 2015

J. Mater. Chem. B

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Preventing chronic hyperglycaemia and associated oxidative stress is utmost important for the treatment and management of Type 2 Diabetes Mellitus (T2DM). Here we report the role of different size surface defect rich ZnO quantum dots (D-QDs) for inhibiting metabolic enzymes and scavenging free radicals, which plays a key role in reducing hyperglycaemia and oxidative stress. Quantitative analysis of radical scavenging and metabolic enzyme inhibition activity of D-QDs demonstrates a size dependent behaviour, where D-QDs with a smaller diameter shows superior activity compared to larger size D-QDs. Considering the size dependence in surface defect formation, the increased surface defect density in smaller size D-QDs can be considered as the reason behind this enhancement. Detailed studies establishing the underlying mechanism behind potent free radical scavenging and enzyme inhibition provides an intense scientific rationale for considering D-QDs to design safe and effective nanomedicine for T2DM.

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“…In comparison with other fluorescent materials such as organic dyes and quantum dots, UCNs exhibit many advantages such as high photochemical stability, sharp emission peaks, large anti-stokes shifts, low toxicity and long lifetime [1][2][3][4][5][6][7][8][9][10][11][12][13]. In addition, high penetration depth and absence of autofluorescence make them ideal materials for biological labeling and in-vivo imaging [14][15][16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Preparation of Upconversion Nanocrystals NaYF4:Yb/Tm with Hydro(solvo)thermal Methods

Zhao¹,

Yin²

2017

Nano BioMed ENG

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A upconversion nanocrystal of NaYF 4 :Yb/Tm was synthesized successfully by two different methods of solvothermal and hydrothermal, respectively. The properties of the products were characterized and compared. The results showed that the nanocrystal prepared by hydrothermal method exhibited uniform hexagonal phase and large size, while the nanocrystal prepared by solvothermal method displayed high upconversion luminescence (UCL) and small size. The UCL intensity of the nanocrystal from solvothermal method was higher than that of hydrothermal method. This is the first time to systematically compare the performances of the upconversion nanocrystal prepared by solvothermal and hydrothermal methods, which provides some new insight into the preparation of upconversion nanomaterials with intense UCL and controllable morphology.

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Ayurvedic Medicine Zinc Bhasma: Physicochemical Evaluation, Anti-Diabetic Activity and Safety Assessment

Cited by 18 publications

References 4 publications

Bhasma : The ancient Indian nanomedicine

Bhasma : The ancient Indian nanomedicine

Surface defect rich ZnO quantum dots as antioxidants inhibiting α-amylase and α-glucosidase: a potential anti-diabetic nanomedicine

Preparation of Upconversion Nanocrystals NaYF4:Yb/Tm with Hydro(solvo)thermal Methods

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