Picrorhiza kurroa Royle ex Benth, belongs to the family Scrophulariaceae has gained immense medicinal value in Ayurvedic as well as in modern medicines including antioxidant, antiinflammatory, anti-pyretic, immunomodulatory, anticancer, hepatoprotective, etc. The present study aimed to ascertain analgesic and antipyretic activities of rhizome extracts of Picrorhiza kurrooa in Wister rats. Methanolic extracts at 260 mg/kg as well as 520 mg/kg exhibited highly significant (P<0.01) analgesic and antipyretic activity by oral dose for analgesic and rectal dose for antipyretic effects. Whereas hydroalcoholic extract showed significant effects at 520 mg/kg but not as good as that of methanolic extracts. INTRODUCTION: Picrorrhiza kurrooa, an herbal medicinal plant belonging to Scrophulariaceae family with around 200 genera and 3000 species, found in the Himalayan regions of China, Pakistan, India, Bhutan and Nepal 1. The plant has been reported for their different pharmacological activities like antioxidant 2 , anticancer 3 , immuno-modulatory 4 antiinflammatory 5 , hepatoprotective 6. The rhizomes of P. kurrooa have been traditionally used to treat liver, respiratory tract disorders, indigestion problems, fever, pain and dyspepsia 7. The chemical studies on the P. kurroa rhizomes revealed the presence of iridoids, acetophenones, and cucurbitacins 8, 9. Pyrexia, algesia is associated with several pathological conditions. It has been reported that the bark of Picrorhiza kurroa and Azadirachta indica, along with fruits of Terminalia chebula,