Axonal reinnervation does not influence Schwann cell proliferation after rat sciatic nerve transection

Siironen, J.; Collan, Y; Röyttä, Matias

doi:10.1016/0006-8993(94)90492-8

Cited by 48 publications

(33 citation statements)

References 34 publications

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“…Previous reports have shown that the rate of proliferation of Schwann cells and the appearance of Schwann cell migratory promoting activity in extracellular fluid were increased considerably at 7 Â14 days after transection, and returned to the control level later [17,18]. Our study has shown that the number of proliferating Schwann cells increased significantly in a lengthened nerve at day 20.…”

Section: Discussionsupporting

confidence: 52%

Repair of peripheral nerve defect by direct gradual lengthening of the distal nerve stump in rats: Cellular reaction

Yamada

Nishiura

Saijilafu

et al. 2009

Scandinavian Journal of Plastic and Reconstructive Surgery and

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We investigated the effects of direct gradual lengthening of the distal stump of a peripheral nerve and subsequent nerve regeneration in rats. A segment 10 mm long was resected from rat sciatic nerve. The distal nerve stump was fixed to a ring and pulled directly at a rate of 1 mm/day using an original external nerve distraction device. After distraction for 10, 15, and 20 days, the lengthened nerves were evaluated macroscopically and immunocytochemically. At day 20, the mean (SD) distances from the ring to the 3 mm and 6 mm distal part, which were marked with sutures on the epineurium, were 7 (0.5) mm and 12.1 (0.5) mm, respectively, and the number of Schwann cells in the lengthening group had increased to twice that of control group. The distal stump of a peripheral nerve including the epineurium, endoneurium, and proliferation of Schwann cells can be lengthened directly. This method also made it possible to lengthen the nerve stump longitudinally and to control both the rate and distance. We think that this method may be used in the treatment of peripheral nerve injury.

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Section: Discussionsupporting

confidence: 52%

Repair of peripheral nerve defect by direct gradual lengthening of the distal nerve stump in rats: Cellular reaction

Yamada

Nishiura

Saijilafu

et al. 2009

Scandinavian Journal of Plastic and Reconstructive Surgery and

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“…The production of NDF could be the result of axonal contact which initiates numerous responses in the SC (Neuberger and DeVries, 1992), and the NDF in SC could possibly function after injury to produce a mitotic or differentiation response in SC. Recent evidence suggests that the re-establishment of axonal contact after nerve injury does not elicit SC mitosis (Siironen et al, 1994). Our laboratory has implicated a myelin basic protein as a potential mitogen for SC after neural injury (Baichwal and DeVries, 1992;Tzeng et al, 1995).…”

Section: Functions Of Neuregulins In Scmentioning

confidence: 98%

Cultured neonatal schwann cells contain and secrete neuregulins

et al. 1996

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“…Injuries to peripheral nerves often result in axonal degeneration and removal of their surrounding myelin sheaths by hematogenous, ED11 (immunoreactive) macrophages (Bruck, 1997;Perry et al, 1987), proliferation of Schwann cells (Siironen et al, 1994), increased expression of collagen RNAs (Siironen et al, 1994(Siironen et al, , 1996, and eventually, perineurial and epineurial thickening as a result of increased deposition of collagen and other extracellular matrix components (Siironen et al, 1992(Siironen et al, , 1996. Many of the signals driving these processes remain unknown.…”

Section: Introductionmentioning

confidence: 96%

Median Nerve Trauma in a Rat Model of Work-Related Musculoskeletal Disorder

Clark

Barr

Safadi

et al. 2003

Journal of Neurotrauma

134

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Anatomical and physiological changes were evaluated in the median nerves of rats trained to perform repetitive reaching. Motor degradation was evident after 4 weeks. ED1-immunoreactive macrophages were seen in the transcarpal region of the median nerve of both forelimbs by 5-6 weeks. Fibrosis, characterized by increased immunoexpression of collagen type I by 8 weeks and connective tissue growth factor by 12 weeks, was evident. The conduction velocity (NCV) within the carpal tunnel showed a modest but significant decline after 9-12 weeks. The lowest NCV values were found in animals that refused to participate in the task for the full time available. Thus, both anatomical and physiological signs of progressive tissue damage were present in this model. These results, together with other recent findings indicate that work-related carpal tunnel syndrome develops through mechanisms that include injury, inflammation, fibrosis and subsequent nerve compression.

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Axonal reinnervation does not influence Schwann cell proliferation after rat sciatic nerve transection

Cited by 48 publications

References 34 publications

Repair of peripheral nerve defect by direct gradual lengthening of the distal nerve stump in rats: Cellular reaction

Repair of peripheral nerve defect by direct gradual lengthening of the distal nerve stump in rats: Cellular reaction

Cultured neonatal schwann cells contain and secrete neuregulins

Median Nerve Trauma in a Rat Model of Work-Related Musculoskeletal Disorder

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