Axonal loss of white matter in migraine without aura: A tract-based spatial statistics study

Abstract

Given that decreased AD may suggest axonal loss, our findings may reveal axonal loss in MWoA.

Regional Homogeneity Abnormalities Affected by Depressive Symptoms in Migraine Patients without Aura: A Resting State Study

“…The consistent results may suggest that the decreased ReHo in these regions is related with migraine. These brain regions with decreased ReHo in MWoA were similar to the brain regions reported in structural [21,22] and functional studies [5,17,22–24] in migraine, which were mainly involved in pain-related processing [22]. In particular, decreased ReHo values in the rACC and the SMA were reported in a previous study [5].…”

Principal Component Analysis of Diffusion Tensor Images to Determine White Matter Injury Patterns Underlying Postconcussive Headache

“…26 However, most interesting, abnormalities of this region are also seen in other forms of chronic headache, such as migraine. 27,28 In fact, in nontraumatic migraine, abnormalities of the splenium are associated with a more chronic disease course, greater headache frequency, and comorbid neuropsychiatric conditions. 15 Lower values of PC 4 also corresponded to increased FA in the genu of the corpus callosum.…”

Differences in Callosal and Forniceal Diffusion between Patients with and without Postconcussive Migraine

“…7,11 However, no studies have yet evaluated the role of white matter injury in the development of PTM, despite white matter injuries being seen with nontraumatic migraine, especially in the corpus callosum (CC). 12,13 Given increasing awareness of white matter injuries underlying nontraumatic migraine, we sought to determine whether there was a relationship between white matter injury and PTM in patients with mTBI. Previous studies have demonstrated that distinct white matter injuries after mTBI result in different and unique postconcussion symptoms, including sleep-wake disturbances, vestibulopathy, and ocular convergence insufficiency.…”