Axonal activity in vivo: technical considerations and implications for the exploration of neural circuits in freely moving animals

Barry, Jeremy M.

doi:10.3389/fnins.2015.00153

Cited by 42 publications

(59 citation statements)

References 74 publications

(145 reference statements)

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“…At this level, the cingulum conveys projections from the anterior thalamus and RSC. Therefore, we hypothesized that we would record a majority of units with short-duration spikes, consistent with axonal spikes (Barry 2015), whose firing and response properties resembled a mixture of ATN and RSC neurons. In agreement with this hypothesis, 23% of cells were classified as HDC ( Suppl.…”

Section: Resultsmentioning

confidence: 99%

Multiplexed code of navigation variables in anterior limbic areas

Laurens

Abrego

Cham

et al. 2019

Preprint

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The brain’s navigation system integrates multimodal cues to create a sense of position and orientation. Here we used a multimodal model to systematically assess how neurons in the anterior thalamic nuclei, retrosplenial cortex and anterior hippocampus of mice, as well as in the cingulum fiber bundle and the white matter regions surrounding the hippocampus, encode an array of navigational variables when animals forage in a circular arena. In addition to coding head direction, we found that some thalamic cells encode the animal’s allocentric position, similar to place cells. We also found that a large fraction of retrosplenial neurons, as well as some hippocampal neurons, encode the egocentric position of the arena’s boundary. We compared the multimodal model to traditional methods of head direction tuning and place field analysis, and found that the latter were inapplicable to multimodal regions such as the anterior thalamus and retrosplenial cortex. Our results draw a new picture of the signals carried and outputted by the anterior thalamus and retrosplenial cortex, offer new insights on navigational variables represented in the hippocampus and its vicinity, and emphasize the importance of using multimodal models to investigate neural coding throughout the navigation system.

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Section: Resultsmentioning

confidence: 99%

Multiplexed code of navigation variables in anterior limbic areas

Laurens

Abrego

Cham

et al. 2019

Preprint

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“…The possibility of recording from axons during extra-cellular recording experiments was indicated in previous studies (Barry, 2015). In the present study, the data do not support significant contamination from dopamine axon recording: dopamine-like activity (“type 1” neuron, or RPE-coding neurons) was observed more often in dopamine fiber-poor areas rather than dopamine projections-heavy areas such as the striatum.…”

Section: Discussionmentioning

confidence: 99%

Distributed and Mixed Information in Monosynaptic Inputs to Dopamine Neurons

Tian

Huang

Cohen

et al. 2016

Neuron

206

233

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SUMMARY Dopamine neurons encode the difference between actual and predicted reward, or reward prediction error (RPE). Although many models have been proposed to account for this computation, it has been difficult to test these models experimentally. Here we established an awake electrophysiological recording system, combined with rabies virus and optogenetic cell-type identification, to characterize the firing patterns of monosynaptic inputs to dopamine neurons while mice performed classical conditioning tasks. We found that each variable required to compute RPE, including actual and predicted reward, was distributed in input neurons in multiple brain areas. Further, many input neurons across brain areas signaled combinations of these variables. These results demonstrate that even simple arithmetic computations such as RPE are not localized in specific brain areas but rather distributed across multiple nodes in a brain-wide network. Our systematic method to examine both activity and connectivity revealed unexpected redundancy for a simple computation in the brain.

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“…The median duration in ADN and CIN (0.2 ms and 0.17 ms, respectively) was significantly smaller (Kruskal-Wallis non-parametric ANOVA, p<10 −10 ) than in RSC (0.44 ms). The CIN is a fiber bundle and neuronal activity recorded therein is therefore expected to consist of axonal spikes, that can be recorded by tetrodes (Robbin et al 2013) and typically exhibit small duration (Barry, 2015). Note that most units recorded in the ADN also had short-duration spikes.…”

Section: On-line Methodsmentioning

confidence: 99%

A gravity-based three-dimensional compass in the mouse brain

Angelaki

Abrego

et al. 2019

Preprint

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SummaryHead direction cells in the mammalian limbic system are thought to function as an allocentric neuronal compass. Although traditional views hold that the compass of ground-dwelling species is planar, we show that head-direction cells in the rodent thalamus, retrosplenial cortex and cingulum fiber bundle are tuned to conjunctive combinations of azimuth, pitch or roll, similarly to presubicular cells in flying bats. Pitch and roll orientation tuning is ubiquitous, anchored to gravity, and independent of visual landmarks. When head tilts, azimuth tuning is affixed to the head-horizontal plane, but also uses gravity to remain anchored to the terrestrial allocentric world. These findings suggest that gravity defines all three degrees of freedom of the allocentric orientation compass, and only the azimuth component can flexibly remap to local cues in different environments. Collectively, these results demonstrate that a three-dimensional, gravity-based, neural compass is likely a ubiquitous property of mammalian species, including ground-dwelling animals.

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Axonal activity in vivo: technical considerations and implications for the exploration of neural circuits in freely moving animals

Cited by 42 publications

References 74 publications

Multiplexed code of navigation variables in anterior limbic areas

Multiplexed code of navigation variables in anterior limbic areas

Distributed and Mixed Information in Monosynaptic Inputs to Dopamine Neurons

A gravity-based three-dimensional compass in the mouse brain

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