Axon‐derived PACSIN1 binds to the Schwann cell survival receptor, LRP1, and transactivates TrkC to promote gliatrophic activities
Stefano Martellucci,
Andreas Flütsch,
Mark Carter
et al.
Abstract:Schwann cells (SCs) undergo phenotypic transformation and then orchestrate nerve repair following PNS injury. The ligands and receptors that activate and sustain SC transformation remain incompletely understood. Proteins released by injured axons represent important candidates for activating the SC Repair Program. The low‐density lipoprotein receptor‐related protein‐1 (LRP1) is acutely up‐regulated in SCs in response to injury, activating c‐Jun, and promoting SC survival. To identify novel LRP1 ligands release… Show more
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