Axitinib attenuates intraplaque angiogenesis, haemorrhages and plaque destabilization in mice

Veken, Bieke Van der; Meyer, Guido R.Y. De; Martinet, Wim

doi:10.1016/j.vph.2017.10.004

Cited by 23 publications

(9 citation statements)

References 32 publications

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“…While Van der Donckt et al reported no dead animals, which is consistent with our own experience, Stöhr et al published a 20% mortality and Johnson et al a mortality rate of 70% after 10 months on WTD (37,38,40). Other reports of WTD for shorter periods show the same variability in mortality rates (42,43). It is unclear whether this variation is a consequence of the ApoE KO or husbandry differences.…”

Section: Discussionmentioning

confidence: 91%

Dare to Compare. Development of Atherosclerotic Lesions in Human, Mouse, and Zebrafish

Vedder

Aherrahrou

Erdmann

2020

Front. Cardiovasc. Med.

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Cardiovascular diseases, such as atherosclerosis, are the leading cause of death worldwide. Although mice are currently the most commonly used model for atherosclerosis, zebrafish are emerging as an alternative, especially for inflammatory and lipid metabolism studies. Here, we review the history of in vivo atherosclerosis models and highlight the potential for future studies on inflammatory responses in lipid deposits in zebrafish, based on known immune reactions in humans and mice, in anticipation of new zebrafish models with more advanced atherosclerotic plaques.

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Section: Discussionmentioning

confidence: 91%

Dare to Compare. Development of Atherosclerotic Lesions in Human, Mouse, and Zebrafish

Vedder

Aherrahrou

Erdmann

2020

Front. Cardiovasc. Med.

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“…Inflammatory mediators facilitate apoptosis, with the formation of necrotic tissue and consequent macrophage activation. The necrotic tissue contributes to the characteristics of the heterogeneous, complex, unstable plaque [ 25 , 26 ].…”

Section: Introductionmentioning

confidence: 99%

Inflammatory Cytokines and Atherosclerotic Plaque Progression. Therapeutic Implications

Sterpetti

2020

Curr Atheroscler Rep

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Purpose of the Review Inflammatory cytokines play a major role in atherosclerotic plaque progression. This review summarizes the rationale for personalized anti-inflammatory therapy. Recent Findings Systemic inflammatory parameters may be used to follow the clinical outcome in primary and secondary prevention. Medical therapy, both in patients with stable cardiovascular disease, or with acute events, may be tailored taking into consideration the level and course of systemic inflammatory mediators. There is significant space for improvement in primary prevention and in the treatment of patients who have suffered from severe cardiovascular events, paying attention to not only blood pressure and cholesterol levels but also including inflammatory parameters in our clinical analysis. Summary The potential exists to alter the course of atherosclerosis with anti-inflammatory drugs. With increased understanding of the specific mechanisms that regulate the relationship between inflammation and atherosclerosis, new, more effective and specific anti-inflammatory treatment may become available.

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“…The viability of IL-17A-stimulated HUVECs was reduced in a dose-dependent manner after 24 and 48 h of exposure to various concentrations of PSORI-CM02 (0.625, 1.25, 2.5, 5, 10, and 15 mg/mL; Figure 1A). Axitinib can effectively inhibit angiogenesis and was thus chosen as the positive control drug for the in vitro experiments (23). The migration of IL-17A-stimulated HUVECs was significantly inhibited after PSORI-CM02 treatment (Figures 1B, C), indicating that HUVEC migration was promoted by IL-17A treatment, but markedly inhibited by PSORI-CM02 treatment.…”

Section: Psori-cm02 Inhibits the Proliferation And Migration Of Il-17a-stimulated Huvecsmentioning

confidence: 99%

Anti-Angiogenic Efficacy of PSORI-CM02 and the Associated Mechanism in Psoriasis In Vitro and In Vivo

Yang

Zhang

et al. 2021

Front. Immunol.

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Psoriasis is a chronic proliferative autoimmune dermatologic disease characterised by abnormal angiogenesis. Thus, regulating angiogenesis in the skin is an important treatment strategy for psoriasis. PSORI-CM02, an empirical Chinese medicine formula optimised from Yin Xie Ling, was created by the Chinese medicine specialist, Guo-Wei Xuan. Clinical studies have shown that PSORI-CM02 is safe and effective for the treatment of psoriasis. However, its anti-psoriatic mechanisms remain to be further explored. In this study, we investigated the effects of PSORI-CM02 on angiogenesis in the skin and the underlying mechanisms in IL-17A-stimulated human umbilical vein endothelial cells (HUVECs) and a murine model of imiquimod (IMQ)-induced psoriasis. In vitro, PSORI-CM02 significantly inhibited the proliferation and migration of IL-17A-stimulated HUVECs in a dose-dependent manner. Further, it markedly regulated the antioxidative/oxidative status and inflammation; suppressed the expression of VEGF, VEGFR1, VEGFR2, ANG1, and HIF-1α; and reduced the phosphorylation of MAPK signalling pathway components in IL-17A-stimulated HUVECs. In vivo studies showed that PSORI-CM02 markedly reduced angiogenesis in the skin of mice with IMQ-induced psoriasis, while significantly rebalancing antioxidant/oxidant levels; inhibiting the production of IL-6, TNF-α, IL-17A, and IL-17F; and repressing the synthesis of angiogenic mediators. In addition, PSORI-CM02 markedly reduced the activation of the MAPK signalling pathway in psoriatic skin tissue. Taken together, our results demonstrated that PSORI-CM02 inhibited psoriatic angiogenesis by reducing the oxidative status and inflammation, suppressing the expression of angiogenesis-related molecules, and inhibiting the activation of the MAPK signalling pathway in vitro and in vivo.

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Axitinib attenuates intraplaque angiogenesis, haemorrhages and plaque destabilization in mice

Abstract: Inhibition of VEGF receptor signalling by axitinib attenuates intraplaque angiogenesis and plaque destabilization in mice.

Cited by 23 publications

References 32 publications

Dare to Compare. Development of Atherosclerotic Lesions in Human, Mouse, and Zebrafish

Dare to Compare. Development of Atherosclerotic Lesions in Human, Mouse, and Zebrafish

Inflammatory Cytokines and Atherosclerotic Plaque Progression. Therapeutic Implications

Anti-Angiogenic Efficacy of PSORI-CM02 and the Associated Mechanism in Psoriasis In Vitro and In Vivo

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