Axis I and II comorbidity in a large sample of patients with obsessive–compulsive disorder

Denys, Damiaan; Tenney, Nienke; Megen, Harold J.G.M. van; Geus, Femke de; Westenberg, H.G.M.

doi:10.1016/s0165-0327(03)00056-9

Cited by 114 publications

(74 citation statements)

References 22 publications

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“…Thus, more studies with larger samples are required to improve assessment of the role of religiosity as a predictor of OCS among medical and other college students. The association with depression was expected, since clinical [33][34][35][36] and epidemiological studies [31,37] have consistently shown depressive disorder as the most common comorbidity in OCD. There are clinical and cognitive similarities between these disorders, including excessive guilt, indecisiveness, catastrophic thoughts (obsessions or ruminations), estimation of risk, and personal responsibility.…”

Section: Prevalence Of Probable Ocd and Associated Factors (Outcome Amentioning

confidence: 92%

Obsessive-Compulsive Symptoms in Medical Students: Prevalence, Severity, and Correlates

et al. 2015

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Probable OCD is more frequent in medical students than in the general population and is associated with depressive symptoms. Efforts are required to identify OCS in this population, particularly among first-year students and to provide treatment, when necessary. Institutional programs that properly receive freshmen, enhancing their integration with other colleagues and their adaptation to the city, may decrease the level of stress and, consequently, OCS severity.

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Section: Prevalence Of Probable Ocd and Associated Factors (Outcome Amentioning

confidence: 92%

Obsessive-Compulsive Symptoms in Medical Students: Prevalence, Severity, and Correlates

et al. 2015

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“…There is a strong association of PD comorbidity with earlier age of onset (Brieger et al 2002, Ozkan & Altindag 2005; greater clinical severity (Ozkan & Altindag 2005); poorer treatment outcome (Farabaugh et al 2005, Ogrodniczuk et al 2001; longer time to remission (Grilo et al 2005, Massion et al 2002; lower long-term social, cognitive, and occupational functioning (Bank & Silk 2001, Denys et al 2004, Smith & Benjamin 2002, Tyrer et al 2003; greater medical utilization (Smith & Benjamin 2002); suicide attempts and completion (Garno et al 2005, Hawton et al 2003; and greater risk of psychopathology in offspring (Abela et al 2005). However, worse outcome-including increased time to remission-is not inevitable (Grilo et al 2000), varies by PD (Grilo et al 2005), and to some extent may reflect methodological flaws rather than true effects (Mulder 2002).…”

Section: Complications Of Comorbiditymentioning

confidence: 99%

Assessment and Diagnosis of Personality Disorder: Perennial Issues and an Emerging Reconceptualization

Clark

2007

Annu. Rev. Psychol.

694

718

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This chapter reviews recent (2000)(2001)(2002)(2003)(2004)(2005) personality disorder (PD) research, focusing on three major domains: assessment, comorbidity, and stability. (a) Substantial evidence has accrued favoring dimensional over categorical conceptualization of PD, and the five-factor model of personality is prominent as an integrating framework. Future directions include assessing dysfunction separately from traits and learning to utilize collateral information. (b) To address the pervasiveness and extent of comorbidity, researchers have begun to move beyond studying overlapping pairs or small sets of disorders and are developing broader, more integrated common-factor models that cross the Axis I-Axis II boundary. (c) Studies of PD stability have converged on the finding that PD features include both more acute, dysfunctional behaviors that resolve in relatively short periods, and maladaptive temperamental traits that are relatively more stable-similar to normal-range personality traits-with increasing stability until after 50 years of age. A new model for assessing PDand perhaps all psychopathology-emerges from integrating these interrelated reconceptualizations.

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“…OCD, a relatively common disorder affecting between 0.6% and 3.0% of the general population [Crino et al, 2005;Stein et al, 1997;Weissman et al, 1992], has a chronic course and is associated with significant social, occupational, and familial impairment [Hollander et al, 1996;Koran et al, 1996;Steketee, 1997], as well as comorbid mood, anxiety, and substance abuse difficulties [Denys et al, 2004;Karno et al, 1988].…”

Section: Introductionmentioning

confidence: 99%

Clinical predictors of early fluoxetine treatment response in obsessive–compulsive disorder

et al. 2006

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Despite wide use, relatively little is known about sociodemographic and clinical characteristics that predict early fluoxetine response. What research has been conducted has produced inconsistent findings, which may be due to the statistical procedures used, and no studies to date have examined predictors of early fluoxetine treatment response. Sixty adults with obsessive-compulsive disorder (OCD) completed an open-label fluoxetine trial for 8 weeks (up to 40 mg) after a 1-week, single-blind, placebo run-in before baseline assessment. The baseline and posttreatment assessment battery included the Yale-Brown Obsessive Compulsive Scale, the Hamilton Rating Scale for Depression, and the Yale Global Tic Severity Scale. Patient characteristics included illness duration, age, age of onset, gender, and pharmacological treatment history. Independent t-tests and multiple logistic regression analysis showed that longer illness duration, older age, and greater symptom severity were associated with nonresponse. Our findings highlight the impact of functional psychiatric impairment on determining those who may respond to treatment. Furthermore, findings suggest early predictors of patients with certain characteristics who may ultimately need adjunctive care to facilitate response.

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Axis I and II comorbidity in a large sample of patients with obsessive–compulsive disorder

Cited by 114 publications

References 22 publications

Obsessive-Compulsive Symptoms in Medical Students: Prevalence, Severity, and Correlates

Obsessive-Compulsive Symptoms in Medical Students: Prevalence, Severity, and Correlates

Assessment and Diagnosis of Personality Disorder: Perennial Issues and an Emerging Reconceptualization

Clinical predictors of early fluoxetine treatment response in obsessive–compulsive disorder

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