Axillary Lymph Node Ultrasound Following Neoadjuvant Chemotherapy in Biopsy-Proven Node-Positive Breast Cancer: Results from the SN FNAC Study

Assessment of axillary node status by ultrasound after neoadjuvant chemotherapy in patients with clinically node-positive breast cancer according to breast cancer subtype

“…Following a secondary analysis of the trial, ACOSOG investigators reported that FNR was reduced to 9.8% by considering AUS assessment following NAC 6 . Similarly, in the SN FNAC trial, FNR was decreased to 2.7% by taking AUS assessment into account 16 . Although both studies showed that AUS reduced FNR, investigators took the position that US alone is not accurate enough to assess axillary response.…”

Breast cancer surgery under the shadow of COVID‐19: Quest for optimal axillary management after neo‐adjuvant chemotherapy

“…The most controversial issue in regard to SLNB after NAC is FNR. Prospective trials encouraged dual mapping, achieving at least 3 SLNs, incorporating immunohistochemistry and TAD to decrease FNR (<10%) 2‐5 . However, ALND is the only option when failed to identify clip intraoperatively.…”

The role of ultrasound elastography and virtual touch tissue imaging in the personalized prediction of lymph node metastasis of breast cancer

“…Normal lymph nodes are similar in shape to small kidneys, and the cortex shows uniform hypo echogenicity, while the medulla shows higher echogenicity (10). However, when axillary lymph node metastasis occurs in breast cancer, the cortex of lymph nodes will show centripetal thickening, and in severe cases, the medulla of lymph nodes will completely disappear (11). With the development of computerized ultrasound imaging, high- Computer elastography can accurately reflect the hardness of the tissue, so as to semi-quantitatively identify the type of axillary lymph node metastasis of breast cancer.…”