Axial Distribution of Arsenic in Individual Human Hairs by Solid Sampling Graphite Furnace AAS

Koons, Robert D.; Peters, C. A.

doi:10.1093/jat/18.1.36

Cited by 39 publications

(19 citation statements)

References 12 publications

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“…The above scenario is closely matched with the observation from other parts of the BDP (Samanta et al 2004;Das et al 1995), and thus may lead to the health crises of the people and perhaps affecting people with As laden diseases. In people with no known exposure to As, the concentration of As in hair is generally 0.02-0.2 μg/g (Valentine et al 1979;Koons and Peters 1994;Wang et al 1994;Kurttio et al 1998) and the values are closely matched with control group of our study area. However, data on As in nails are sparse, but normal values appear to range from 0.02 to 0.5 μg/g (Narang et al 1987;Takagi et al 1988).…”

Section: Distribution Of Arsenic In Biological Systemsupporting

confidence: 70%

Hydrochemistry of Arsenic-Enriched Aquifer from Rural West Bengal, India: A Study of the Arsenic Exposure and Mitigation Option

Nath

Sahu

Jana

et al. 2007

Water Air Soil Pollut

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The present study aims to understand the hydrochemistry vis-à-vis As-exposure from drinking groundwater in rural Bengal. The characteristic feature of the groundwaters are low Eh (range, −151 to −37 mV; mean, −68 mV) and nitrate (range, 0.01-1.7 mg/l; mean, 0.14 mg/l) followed by high alkalinity (range, 100-630 mg/l; mean, 301 mg/l), Fe (range, 0.99-38 mg/l; mean, 8.1 mg/l), phosphate (range, 0.01-15 mg/l; mean, 0.54 mg/l), hardness (range, 46-600 mg/l; mean, 245 mg/l) and sulphate (range, 0.19-88 mg/l; mean, 7.2 mg/l), indicating reducing nature of the aquifer. The land use pattern (sanitation, surface water bodies, sanitation coupled with surface water bodies and agricultural lands) demonstrates local enrichment factor for As/Fe in groundwater. Among these, sanitation is the most prevailing where groundwater is generally enriched with As (mean, 269 μg/l) and Fe (mean, 9.8 mg/l). Questionnaire survey highlights that ∼70% of the villagers in the study area do not have proper sanitation. This demonstrating the local unsewered sanitation (organic waste, anthropogenic in origin) could also cause As toxicity in rural Bengal. In the agricultural lands, higher mean values of alkalinity, phosphate, sulphate, hardness and electrical conductivity was observed, and could be linked with the excessive use of fertilizers for agricultural production. Bio-markers study indicates that the accumulation of As in hair and nail is related with the construction of exposure scenario with time dimension. The strength and weakness of the on-going West Bengal and Bangladesh drinking water supply scenario and achievability towards alternative options are also evaluated.

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Section: Distribution Of Arsenic In Biological Systemsupporting

confidence: 70%

Hydrochemistry of Arsenic-Enriched Aquifer from Rural West Bengal, India: A Study of the Arsenic Exposure and Mitigation Option

Nath

Sahu

Jana

et al. 2007

Water Air Soil Pollut

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“…Individuals exposed to ambient levels of As have hair As levels ranging from 0.02 to 0.2 μg/g ( Kapaj et al 2006; Koons and Peters 1994; Kurttio et al 1998; Narang et al 1987; Olguín et al 1983; Paulsen et al 1996; Raie 1996; Takagi et al 1988; Valentine et al 1979; Vienna et al 1995; Wang et al 1994; Wolfsperger et al 1994). In the present study, we were unable to associate exposure with hair As levels, and it is difficult to discern how hair could become an alternative biometric for examining arsenic body burden at moderately elevated exposure conditions on a population or individual basis.…”

Section: Discussionmentioning

confidence: 99%

“…Persons with no known exposure to As have hair As levels ranging from 0.02 to 0.2 μg/g, whereas individuals exposed to elevated levels of As in drinking water have hair As levels ranging from 3 to 10 μg/g (Das et al 1995; Kapaj et al 2006; Koons and Peters 1994; Kurttio et al 1998; Narang et al 1987; Olguín et al 1983; Paulsen et al 1996; Raie 1996; Takagi et al 1988; Valentine et al 1979; Vienna et al 1995; Wang et al 1994; Wolfsperger et al 1994). …”

mentioning

confidence: 99%

Arsenic Exposure within the Korean Community (United States) Based on Dietary Behavior and Arsenic Levels in Hair, Urine, Air, and Water

Cleland

Tsuchiya

Kalman³

et al. 2009

Environ Health Perspect

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BackgroundDetermining arsenic exposure in groups based on geographic location, dietary behaviors, or lifestyles is important, as even moderate exposures may lead to health concerns.Objectives/MethodsThe Korean community in Washington State, represents a group warranting investigation, as they consume foods (e.g., shellfish, rice, finfish, and seaweed) known to contain arsenic. As part of the Arsenic Mercury Intake Biometric Study, we examined the arsenic levels in hair and urine along with the diets of 108 women of childbearing age from within this community. Arsenic levels in indoor air and drinking water were also investigated, and shellfish commonly consumed were collected and analyzed for total and speciated arsenic.ResultsThe six shellfish species analyzed (n = 667) contain total arsenic (range, 1–5 μg/g) but are a small source of inorganic arsenic (range, 0.01–0.12 μg/g). Six percent of the individuals may have elevated urinary inorganic arsenic levels (> 10 μg/L) due to diet. Seaweed, rice, shellfish, and finfish are principal sources for total arsenic intake/excretion based on mass balance estimates. Rice consumption (163 g/person/day) may be a significant source of inorganic arsenic. Air and water are not significant sources of exposure. Hair is a poor biometric for examining arsenic levels at low to moderate exposures.ConclusionsWe conclude that a portion of this community may have dietary inorganic arsenic exposure resulting in urine levels exceeding 10 μg/L. Although their exposure is below that associated with populations exposed to high levels of arsenic from drinking water (> 100 μg/L), their exposure may be among the highest in the United States.

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“…2) indicates that the exposure took place over at least two months. In single arsenic ingestions, the concentration in the first cm shows much higher arsenic concentration than in the next cm of the hair collected immediately after exposure (39,40).…”

Section: Discussionmentioning

confidence: 99%

Slow recovery from severe inorganic arsenic poisoning despite treatment with DMSA (2.3-dimercaptosuccinic acid)

Stenehjem

Vahter

Nermell

et al. 2007

Clinical Toxicology

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A 39-year-old woman was hospitalized for nausea, diarrhea, vomiting, and weakness of unknown etiology. Her condition progressively deteriorated and she developed multiple organ failure and tetraplegia. The diagnosis of inorganic arsenic poisoning was established by measurements of arsenic in urine and serum, showing 2,000 microg/L (normal < 10 microg/L) and 290 mug/Kg (normal < 2 microg/Kg), respectively. Hair arsenic was 57 mg/kg (normal < 0.2 mg/kg). Chelating therapy with 2.3-dimercaptosuccinic acid (DMSA) 600 mg three times daily was given for a period of 45 days with three abruption periods during a total of 13 days. The clinical manifestations of arsenic toxicosis disappeared very slowly and five years after the hospitalization she still suffers from peripheral neuropathy. Although the use of DMSA was associated with increased urinary elimination of arsenic and a decrease in blood arsenic concentrations, DMSA treatment probably had no significant effect on the total body clearance in our patient. The source of the poisoning was never detected, nor the motivation behind it. Criminal intent was suspected, but no verdict was given.

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Axial Distribution of Arsenic in Individual Human Hairs by Solid Sampling Graphite Furnace AAS

Cited by 39 publications

References 12 publications

Hydrochemistry of Arsenic-Enriched Aquifer from Rural West Bengal, India: A Study of the Arsenic Exposure and Mitigation Option

Hydrochemistry of Arsenic-Enriched Aquifer from Rural West Bengal, India: A Study of the Arsenic Exposure and Mitigation Option

Arsenic Exposure within the Korean Community (United States) Based on Dietary Behavior and Arsenic Levels in Hair, Urine, Air, and Water

Slow recovery from severe inorganic arsenic poisoning despite treatment with DMSA (2.3-dimercaptosuccinic acid)

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