Awareness of Genetic Testing for Increased Cancer Risk in the Year 2000 National Health Interview Survey

Wideroff, Louise; Vadaparampil, Susan T.; Breen, Nancy; Croyle, Robert T.; Freedman, Andrew

doi:10.1159/000078162

Cited by 67 publications

(72 citation statements)

References 39 publications

(43 reference statements)

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“…[19][20][21][22][23] This may be explained in part by factors such as education, acculturation, and region of residence, although differences remain apparent even after adjustment for many sociodemographic factors. 21 To our knowledge, however, this is the first study to report that Hispanics and African Americans who are aware of genetic testing are more likely to discuss it with their physicians or to undergo testing when advised by their physicians.…”

Section: Discussionmentioning

confidence: 99%

Familial Risk of Cancer and Knowledge and Use of Genetic Testing

et al. 2010

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BACKGROUND: Identification of genetic risk factors for common diseases, including cancer, highlights the importance of familial risk assessment. Little is known about patterns of familial cancer risk in the general population, or whether this risk is associated with knowledge and use of genetic testing. OBJECTIVE: To examine the distribution of familial cancer risk and its associations with genetic testing in the United States. DESIGN: Cross-sectional analysis of the 2005 National Health Interview Survey (NHIS). PARTICIPANTS: 31,428 adults who completed the NHIS Cancer Control Supplement. MAIN MEASURES: Familial cancer risk was estimated based on the number of first-degree relatives with a breast and ovarian cancer syndrome (BRCA)-or a Lynchassociated cancer, age of onset (<50 or ≥50 years), and personal history of any cancer. Outcomes included having heard of genetic testing, discussed genetic testing with a physician, been advised by a physician to have testing, and received genetic testing. KEY RESULTS: Most adults (84.5%) had no family history of BRCA-or Lynch syndrome-associated cancer; 12.9% had a single first-degree relative (5.3% with early onset); and 2.7% had ≥2 first-degree relatives. Although 40.2% of adults had heard of genetic testing for cancer risk, only 5.6% of these individuals had discussed testing with a physician, and of these 36.9% were advised to be tested. Overall, only 1.4% of adults who had heard of genetic testing received a test. Familial risk was associated with higher rates of testing; 49.5% of participants in the highest risk group had heard of testing, of those 14.8% had discussed it with their physician, and 4.5% had received genetic testing. CONCLUSIONS: These nationally representative data provide estimates of the prevalence of familial cancer risk in the US and suggest that information about genetic testing is not reaching many at higher risk of inherited cancer.KEY WORDS: family history; primary care practice; cancer.

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Section: Discussionmentioning

confidence: 99%

Familial Risk of Cancer and Knowledge and Use of Genetic Testing

et al. 2010

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“…This may reflect women's minimal knowledge about GT. Data from both the 2000 and 2005 National Health Interview Survey suggested that less than one third of Puerto Rican women have heard of GT for inherited cancer susceptibility, compared to approximately half of all Whites (Heck et al 2008;Vadaparampil et al 2006;Wideroff et al 2003). A recent analysis of qualitative data from the larger study based in Tampa further supports this lack of familiarity with cancer-related GT as participants from various Hispanic ethnicities, including Puerto Rico, would not know how to describe GT to a friend (Vadaparampil et al 2010a).…”

Section: Knowledge About Hereditary Cancer By Locationmentioning

confidence: 99%

A pilot study of knowledge and interest of genetic counseling and testing for hereditary breast and ovarian cancer syndrome among Puerto Rican women

et al. 2011

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This study explored baseline levels of knowledge and attitude toward genetic testing (GT) for hereditary breast and ovarian cancer among Puerto Rican women. A secondary aim was to evaluate whether these factors differed between respondents in Puerto Rico and Tampa. Puerto Rican women with a personal or family history of breast or ovarian cancer who live in Puerto Rico (n=25) and Tampa (n=20) were interviewed. Both groups were interested in obtaining GT; women living in Puerto Rico were more likely to report they would get GT within 6 months (p=0.005). The most commonly cited barrier was cost; the most commonly cited facilitator was provider recommendation. There was no difference in overall knowledge between Tampa (M=5.15, SD=1.63) and Puerto Rico (M=5.00, SD=1.87) participants (p=0.78). Involving health care providers in recruitment and highlighting that GT may be available at minimal or no cost in the USA and Puerto Rico may facilitate participation.

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“…However, this awareness varies by socio-demographics, family history, access to information through the health care system (Meischke et al, 2001;Benjamin-Garner et al, 2002;Wideroff et al, 2003;Vadaparampil et al, 2006) and the perceived personal risk (Bottorff et al, 2002;Bruno et al, 2004). Also, individual's decision regarding whether or not to seek clinical cancer genetic services may also be influenced by knowledge, cognitions, emotions, family communication, and socio-demographic and clinical characteristics (Bottorff, 2002;Kinney et al 2006;Ropk et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Saudi Women's Interest in Breast Cancer Gene Testing: Possible Influence of Awareness, Perceived Risk and Socio-demographic Factors

Amin¹,

Al-Wadaani²,

Al-Quaimi³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Background: Development of effective educational strategies should accompany increases in public awareness and the availability of genetic testing for breast cancer (BC). These educational strategies should be designed to fulfill the knowledge gap while considering factors that influence women's interest in order to facilitate decision making. Objective: To determine the possible correlates of Saudi women's interest in BC genes testing including socio-demographics, the level of awareness towards BC genes, the family history of BC and the perceived personal risk among adult Saudi women in Al Hassa, Saudi Arabia. Subjects and methods: This cross-sectional study was carried out during the second BC community-based campaign in Al Hassa, Saudi Arabia. All Saudi women aged ≥ 18 years (n=781) attending the educational components of the campaign were invited to a personal interview. Data collection included gathering information about sociodemographics, family history of BC, the perceived personal risk for BC, awareness and attitude towards BC genes and the women's interest in BC genes testing. Results: Of the included women (n=599), 19.5% perceived higher risk for BC development, significantly more among < 40 years of age, and with positive family history of BC before 50 years of age. The participants demonstrated a poor level of awareness regarding the inheritance, risk, and availability of BC genetic testing. The median summated knowledge score was 1.0 (out of 7 points) with a knowledge deficit of 87.8%. The level of knowledge showed significant decline with age (> 40 years). Of the included women 54.7% expressed an interest in BC genetic testing for assessing their BC risk. Multivariate regression model showed that being middle aged (Odds Ratio 'OR'=1.88, confidence intervals 'C.I'=1.14-3.11), with higher knowledge level (OR=1.67, C.I=1.08-2.57) and perceiving higher risk for BC (OR=2.11, C.I=1.61-2.76) were the significant positive correlates for Saudi women interest in BC genetic testing. Conclusion: Saudi women express high interest in genetic testing for BC risk despite their poor awareness. This great interest may reflect the presence of inappropriate information regarding BC genetic testing and its role in risk analysis.

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Awareness of Genetic Testing for Increased Cancer Risk in the Year 2000 National Health Interview Survey

Cited by 67 publications

References 39 publications

Familial Risk of Cancer and Knowledge and Use of Genetic Testing

Familial Risk of Cancer and Knowledge and Use of Genetic Testing

A pilot study of knowledge and interest of genetic counseling and testing for hereditary breast and ovarian cancer syndrome among Puerto Rican women

Saudi Women's Interest in Breast Cancer Gene Testing: Possible Influence of Awareness, Perceived Risk and Socio-demographic Factors

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