Awareness during anaesthesia: a prospective case study

Sandin, R.; Enlund, Gunnar; Samuelsson, Peter; Lennmarken, C.

doi:10.1016/s0140-6736(99)11010-9

Cited by 602 publications

(425 citation statements)

References 8 publications

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“…In turn, anesthetics are currently being used as powerful probes to gain fundamental insights into the biology and neuronal substrates of memory. Such insights may allow the development of strategies to prevent and treat memory disorders associated with anesthetic states, such as intraoperative awareness [149][150][151] and memory deficits in the postoperative period. [152][153][154] …”

Section: Discussionmentioning

confidence: 99%

Inhibition of learning and memory by general anesthetics

Wang

Orser

2010

Can J Anesth/J Can Anesth

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Section: Discussionmentioning

confidence: 99%

Inhibition of learning and memory by general anesthetics

Wang

Orser

2010

Can J Anesth/J Can Anesth

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“…5,6 However, patient factors may contraindicate the use of NMBDs, and administration of NMBDs may be associated with several potentially serious complications, such as anaphylactic reactions, residual curarization (even after a single intubating dose of NMBD), and awareness during general anesthesia. [7][8][9] Moreover, high rates of good to excellent intubating conditions have been reported without the use of NMBDs, provided that the anesthetic induction protocol is optimized with an adequate dose of an opioid analgesic co-administered with either propofol or thiopental. [10][11][12][13][14][15][16] Due to its rapid onset, remifentanil 2 µg·kg -1 , combined with propofol 2 mg·kg -1 , provides acceptable intubating conditions in 75 to 85% of patients.…”

Section: Conclusion : à La Suite D'une Induction De L'anesthésie à L'mentioning

confidence: 99%

Laryngeal injuries and intubating conditions with or without muscular relaxation: an equivalence study

Bouvet

Stoian

Jacquot-Laperrière

et al. 2008

Can J Anesth/J Can Anesth

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Purpose:The need for muscular relaxation to improve intubating conditions and to reduce the incidence of laryngeal morbidity is still controversial. The aim of this study was to determine the incidence of symptomatic laryngeal injuries (SLI) and of acceptable intubating conditions (including both good and excellent conditions), both with and without cisatracurium during induction of anesthesia, along with moderate doses of remifentanil and propofol. Methods:In this prospective, randomized double-blind equivalence trial, the intubating conditions were compared in 130 ASA I or II female patients. All subjects received remifentanil 2 µg·kg -1 iv and propofol 2.5 mg·kg -1 iv, with either cisatracurium 0.15 mg·kg -1 iv (group Cisatracturium), or saline (group Placebo). Tracheal intubating conditions were assessed with the Copenhagen Score. A systematic screening for postoperative hoarseness and sore throat was performed 24 and 48 hr after anesthesia, followed by a nasofibroscopic examination when laryngeal symptoms persisted at 48 hr.Results: Twenty-four hr after anesthesia, the incidence of postoperative hoarseness and sore throat in the Cisatracurium and Placebo groups was 26.5% and 21.5%, respectively, and 48 hr after anesthesia, the incidence was 7.8% and 6.1%, respectively (P = 0.32 and P = 0.50 between groups, respectively). In the clinically evaluable population, the incidence of SLI, assessed at 48 hr by nasofibroscopy, was equivalent in both groups, 1.6% vs 1.5% in group Placebo and group Cisatracurium, respectively (P < 0.001 for equivalence test), as was the occurrence of acceptable intubating conditions (95.4% vs 100%, P < 0.05 for equivalence test). However, the occurrence of excellent intubating conditions was more frequent in group Cisatracurium than in group Placebo (P = 0.0003). Conclusion:Following induction of anesthesia with propofol and moderate-dose remifentanil, cisatracurium did not confer a higher rate of good-to-excellent conditions for tracheal intubation, nor did muscle relaxation with cisatracurium decrease the rate of SLI after tracheal intubation.

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“…The incidence of actual awareness may be in the range of 18/11785 or 0.15%. 43 Consequently, a randomized controlled trial to prove one way or another that ß-blockers increase the incidence of intraoperative awareness would require a huge sample size and be difficult to conduct.…”

mentioning

confidence: 99%

“…L'incidence de conscience réelle pourrait être de l'ordre de 18 / 11 785 ou de 0,15 %. 43 Par conséquent, un essai randomisé et contrôlé visant à prouver d'une façon ou d'une autre que les ß-bloquants augmentent l'incidence de conscience peropératoire exigerait un échan-tillon imposant et serait difficile à réaliser.…”

unclassified

Are β-blockers anesthestics?

Yang

Fayad

2003

Can J Anesth/J Can Anesth

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Awareness during anaesthesia: a prospective case study

Cited by 602 publications

References 8 publications

Inhibition of learning and memory by general anesthetics

Inhibition of learning and memory by general anesthetics

Laryngeal injuries and intubating conditions with or without muscular relaxation: an equivalence study

Are β-blockers anesthestics?

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