Awareness, attitude and behavior regarding proton pump inhibitor among medical staff in the Southwest of China

Abstract

BackgroundProton pump inhibitors (PPIs) are one of the most frequently prescribed classes of drug in the world and there is a growing number of publications on correct versus incorrect use of PPIs worldwide. The knowledge of PPIs among the medical staff is essential for improving the rationality of PPI application. The present study aimed to investigate awareness, attitude and behavior toward PPI use among medical staff in the Southwest of China.MethodsThe present descriptive-analytical study was conducted on 900 medical staff from three professional groups (300 doctors, 300 nurses and 300 pharmacists) in China. The study data were collected through a self-designed questionnaire which included demographics, awareness, attitude and behavior toward PPI use. The study was carried out in 22 hospitals in Luzhou between February and June 2018.ResultsOf 900 surveys issued, 851valid questionnaires (295doctors, 268 nurses and 288 pharmacists) were returned. Of all respondents, 33.25% were men and 66.75% were women. The score related to PPI awareness score of medical staff was low (59.47 ± 15.75). The level of awareness of pharmacist was significantly higher than that of doctors and nurses (P < 0.01), which was related to gender, age, occupation, educational level, professional title, hospital nature and hospital grade. Similarly, on the attitude towards PPI use, the pharmacists scored also significantly higher than doctors and the nurses (P < 0.01). Three hundred eighty-one of 851 medical staff had used PPI in the past 1 year, of which omeprazole was the most widely used. Among doctors, nurses and pharmacists, the usage rate of PPI was 50.85, 42.16, 40.97%, respectively. The use frequency was related to occupation and professional title. The score about the behavior toward PPIs of the nurses was also significantly lower than that of doctors and pharmacists (P < 0.01).ConclusionsThe study indicated that the medical staff lack of awareness concerning rational use of PPI in China, especially nurse. Thus, it is necessary to call for action on the improvement of PPI awareness and medication-taking behaviors to reduce PPI overuse and to promote the rationality of PPI application.

Patients, Prescribers, and Institutional Factors Associated with Inappropriate Use of Acid Suppressive Therapy in Medical Wards: An Experience of a Single-Center in Saudi Arabia

“…To investigate the prescriber-related factors and institution-related factors, we developed an English language survey including factors identified in previous studies and published questionnaires to construct the survey questions. 18,[20][21][22] Initially, the questionnaire was piloted on five prescribers for phase and content validity. The data from the pilot were not included in the analysis.…”

Simultaneous Quantitative Analysis of Six Proton-Pump Inhibitors with a Single Marker and Evaluation of Stability of Investigated Drugs in Polypropylene Syringes for Continuous Infusion Use

“…Based upon previously published meta-analyses and evidence-based guidelines on peptic ulcer, this study was carried out to mimic as closely as possible a projected routine use of the six PPI agents. [6][7][8][9][10] Commercially available OPZ, EOPZ, LPZ, PPZ, RPZ or IPZ were mixed in 50 mL polypropylene syringes (Jierui, Weigao Med., Shangdong, China) of 0.9% sodium chloride injection at concentrations of 1.6 mg/mL, 1.6 mg/mL, 1.2 mg/mL, 1.6 mg/mL, 0.8 mg/mL and 0.8 mg/mL, respectively. All admixtures were investigated at room temperature (25 ±0.5°C) over 48 hours with light protection or light exposure.…”

“…They work by blocking the K + -H + - adenosine triphosphates enzyme system (the proton pump) and thereby inhibit gastric acid. 5 , 6 The first PPI, omeprazole (OPZ), was introduced in 1989, and other drugs in the class now include esomeprazole (EOPZ), lansoprazole (LPZ), pantoprazole (PPZ), rabeprazole (RPZ) and ilaprazole (IPZ). 7–10…”

“…They work by blocking the K + -H + -adenosine triphosphates enzyme system (the proton pump) and thereby inhibit gastric acid. 5,6 The first PPI, omeprazole (OPZ), was introduced in 1989, and other drugs in the class now include esomeprazole (EOPZ), lansoprazole (LPZ), pantoprazole (PPZ), rabeprazole (RPZ) and ilaprazole (IPZ). [7][8][9][10] OPZ is substituted benzimidazole and has the chemical name 5-methoxy-2-[[(4-methoxy-3, 5-dimethyl-2-pyridinyl) methyl] sulfinyl] −1H-benzimidazole.…”

Use of proton pump inhibitors: An exploration of awareness, attitude and behavior of health care professionals of Riyadh, Saudi Arabia

“…Published literatures display the positive result of clinical pharmacist intervention in reducing the inappropriate utilization of PPIs ( Luo et al, 2017 , Agee et al, 2015 ). Another investigation recorded lack of awareness on the normal utilization of PPIs among health care professionals especially nurses, while, the degree of consciousness of pharmacist was fundamentally more compared to doctors and nurses ( Luo et al, 2019 ). Given the high predominance of PPI utilization in the Saudi Arabia ( Basheikh et al, 2017 ), there is a need to investigate the degree of awareness, attitude and practices of the healthcare professionals so that it will help health care authorities on developing strategies on safe PPI use.…”