Awareness and uptake of measures for preventing CNS birth defects among mothers of affected children in a sub-Saharan African neurosurgeon’s practice

Adeleye, Amos Olufemi; Joel-Medewase, Victor Idowu

doi:10.1007/s00381-015-2718-2

Cited by 4 publications

(3 citation statements)

References 32 publications

(38 reference statements)

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“…In the series by van den Berg et al [21], neural tube defects accounted for 45% of the non-traumatic SCD among the paediatric population. This high number of neural tube defect in our study may in part be explained by the well-known poor awareness of neural tube defect prevention measures among women of child bearing ages and absence of a robust nationwide neural tube defect prevention programme in our country [22][23][24]. This calls for a robust national policy on the highly preventable neonatal/paediatric disease burden.…”

Section: Discussionmentioning

confidence: 78%

Clinical profile of paediatric spinal cord damage in a developing country’s rural-area tertiary hospital neurosurgery

Oyemolade,

Adeleye,

Ekanem

2023

Egypt J Neurosurg

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Background Spinal cord damage (SCD) is rare in children, hence the paucity of literature on the subject, particularly in developing countries. This study aims to define the clinical epidemiology of paediatric SCD in a Nigerian tertiary health facility. Methods A retrospective review of a 42-month long prospectively collected clinical data on paediatric SCD in a rural neurosurgery unit. Results There were 37 children (20 males) accounting for about 12% of the paediatric neurosurgical patients we managed during the study period. The mean age was 6.9 years (peak = 0–4 years, 43.2%). Traumatic spinal cord injury (SCI) was the cause of SCD in 54.1% (20/37) of the cases, spinal bifida in 37.8%, spinal cord tumour in 5.4%, and spinal tuberculosis in 2.7%. The mean age of patients with traumatic SCI was 11.5 years, while the median age for spinal bifida was 3 days. Traumatic SCI was caused by road traffic accident in 70% (14/20), and falls in 25%. The cervical spinal cord was the location of the spinal cord damage in 51.4% of all the cases in this study, lumbosacral in 24.3%, and sacral in 10.8%. Traumatic SCI was predominantly located in the cervical region in (90%, 18/20) while spinal bifida was most commonly lumbosacral (64.3%, 9/14). Conclusion Spinal cord damage accounted for more than a tenth (12.1%) of our paediatric neurosurgical workload in this rural neurosurgery, and are mostly due to traumatic SCI and spinal bifida.

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Section: Discussionmentioning

confidence: 78%

Clinical profile of paediatric spinal cord damage in a developing country’s rural-area tertiary hospital neurosurgery

Oyemolade,

Adeleye,

Ekanem

2023

Egypt J Neurosurg

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“…This reflects problems with patient education on perinatal anti-epileptic use and is a known problem of poor maternal awareness of perinatal MMC risk factors in our region. 17 , 18…”

Section: Discussionmentioning

confidence: 99%

Single surgeon case series of myelomeningocele repairs in a developing world setting: Challenges and lessons

Naicker

Leola

Mkhaliphi

et al. 2023

World Neurosurgery: X

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“…To our knowledge, this is the first case described in Central Africa. The lack of similar reports is most likely due to the lack of awareness of congenital malformations in certain regions of the world, including Sub‐Saharan Africa region (Adeleye & Joel‐Medewase, 2015; Zhu et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Agnathia otocephaly: A case from the Katanga Copperbelt

Kayembe‐Kitenge

Kadiamba

Luca

et al. 2020

Birth Defects Research

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Background: Agnathia otocephaly is a rare craniofacial malformation complex characterised by absent/hypoplastic mandible, abnormally positioned ears meeting at level of neck. Besides mutations in two genes, PRRX1 and OTX2, a teratogenic cause has been suggested. A higher risk of congenital malformations has been associated with paternal work in mining in the Democratic Republic of the Congo's part of the Copperbelt. Case: We studied a female neonate with a clinical diagnosis of agnathia otocephaly, stillborn in Lubumbashi in 2019. The child's father had been working as an artisanal mineworker at the time of conception. Results: Genetic analysis did not reveal a causal mutation. The concentrations of cobalt, arsenic cadmium, and uranium in cord blood of the infant were much higher than those of normal neonates from a previous study. Conclusion: In the absence of identified genetic causes, we hypothesize this case of agnathia otocephaly was related to an exogenous cause, possibly the father's mining-related job.

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Awareness and uptake of measures for preventing CNS birth defects among mothers of affected children in a sub-Saharan African neurosurgeon’s practice

Cited by 4 publications

References 32 publications

Clinical profile of paediatric spinal cord damage in a developing country’s rural-area tertiary hospital neurosurgery

Clinical profile of paediatric spinal cord damage in a developing country’s rural-area tertiary hospital neurosurgery

Single surgeon case series of myelomeningocele repairs in a developing world setting: Challenges and lessons

Agnathia otocephaly: A case from the Katanga Copperbelt

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