Awareness and knowledge of congenital cytomegalovirus infection among health care providers in France

Cordier, Anne-Gaël; Guitton, S.; Vauloup‐Fellous, Christelle; Grangeot-Keros, L.; Benachi, Alexandra; Picone, Olivier

doi:10.1016/j.jcv.2012.06.022

Cited by 63 publications

(81 citation statements)

References 19 publications

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“…In 2012, Cordier et al [14] showed that the knowledge of French practitioners concerning the transmission, symptoms and management of fetal CMV infection was poor. Only 5% of respondents knew all the health precautions required to prevent maternal infection, and 69% of respondents reported that they gave their patients no information on CMV infection.…”

Section: Discussionmentioning

confidence: 99%

“…This can be a source of bias, common to all publications based on questionnaires [9,14]. We cannot be sure that the respondents are representative of the 5,000 specialists in obstetrics and gynecology and the 18,000 midwives who are present in France.…”

Section: Discussionmentioning

confidence: 99%

“…This leads to multiple, nonstandard treatments based sometimes on the personal convictions of health care practitioners rather than on solid scientific evidence. A previous study showed that the knowledge of French practitioners concerning CMV infection was inadequate [14], but it did not assess treatment practices.…”

Section: Introductionmentioning

confidence: 99%

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Management of Cytomegalovirus Seroconversion during Pregnancy in France

Carrara¹,

Ndiaye²,

Azria³

et al. 2015

Fetal Diagn Ther

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Introduction: Guidelines for the management of cytomegalovirus (CMV) infection of the fetus are rare. Our main objective was to evaluate how health care practitioners in France manage cases of CMV seroconversion during pregnancy. Material and Methods: A questionnaire was e-mailed to health care practitioners potentially concerned by CMV seroconversion during pregnancy. They were asked if they would recommend amniocentesis, fetal cerebral MRI examination and fetal blood analysis (FBA), depending on the ultrasound results. They then had to indicate whether they would accept termination of pregnancy (TOP), depending on the results of these examinations. Results: A total of 380 health care practitioners responded, mainly obstetricians (73.9%) and midwives (20.2%). Overall, 57% of respondents recommended amniocentesis in the case of CMV seroconversion during the first trimester of pregnancy, ultrasound findings being normal. In cases of positive amniocentesis and a major ultrasound abnormality, 84.5% of respondents would perform cerebral MRI, and 44.4% would perform FBA. In this case, the rate of acceptance of TOP was not significantly different whether the examinations were normal (337/372, 90.6%) or not performed (339/374, 93.3%; p = 0.17). Discussion: Amniocentesis is too infrequently used and should be encouraged. The results of MRI and FBA are often not taken into account in the final decision concerning TOP. Guidelines are needed to clarify the management of CMV seroconversion during pregnancy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Management of Cytomegalovirus Seroconversion during Pregnancy in France

Carrara¹,

Ndiaye²,

Azria³

et al. 2015

Fetal Diagn Ther

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“…Despite the frequency of congenital CMV infection and the serious consequences that may result from it, a large proportion of the population is not aware of the impact of this infection 18 . In fact, most gynecologists do not counsel women regarding congenital CMV infection 19 ; nevertheless, most women are receptive to informative messages about prevention of this infection. Our study provided information to the students about their serological status and about the importance of CMV infection and its consequences, especially regarding the possibility of CMV transmission during pregnancy and the risk that congenital CMV infection represents.…”

Section: Discussionmentioning

confidence: 99%

Analysis of risk factors associated to cytomegalovirus infection in dentistry students.

Tejera-Hernández¹,

Noyola²,

Sánchez-Vargas³

et al. 2015

J Oral Res

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“…Human cytomegalovirus (HCMV) is the most common cause of intrauterine infections worldwide, with seroprevalence rates at the range from 40 to 100% among pregnant women [1–4]. Our recent study, performed among Polish pregnant women between 2010 and 2011, showed seroprevalence of anti-HCMV IgG and IgM antibodies to have been 62.4 and 2.2%, respectively [4].…”

Section: Introductionmentioning

confidence: 99%

Toll-like receptors genes polymorphisms and the occurrence of HCMV infection among pregnant women

Wujcicka

Paradowska

Studzińska

et al. 2017

Virol J

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BackgroundHuman cytomegalovirus (HCMV) is the most common cause of intrauterine infections worldwide. The toll-like receptors (TLRs) have been reported as important factors in immune response against HCMV. Particularly, TLR2, TLR4 and TLR9 have been shown to be involved in antiviral immunity. Evaluation of the role of single nucleotide polymorphisms (SNPs), located within TLR2, TLR4 and TLR9 genes, in the development of human cytomegalovirus (HCMV) infection in pregnant women and their fetuses and neonates, was performed.MethodsThe study was performed for 131 pregnant women, including 66 patients infected with HCMV during pregnancy, and 65 age-matched control pregnant individuals. The patients were selected to the study, based on serological status of anti-HCMV IgG and IgM antibodies and on the presence of viral DNA in their body fluids. Genotypes in TLR2 2258 A > G, TLR4 896 G > A and 1196 C > T and TLR9 2848 G > A SNPs were determined by self-designed nested PCR-RFLP assays. Randomly selected PCR products, representative for distinct genotypes in TLR SNPs, were confirmed by sequencing. A relationship between the genotypes, alleles, haplotypes and multiple variants in the studied polymorphisms, and the occurrence of HCMV infection in pregnant women and their offsprings, was determined, using a logistic regression model.ResultsGenotypes in all the analyzed polymorphisms preserved the Hardy-Weinberg equilibrium in pregnant women, both infected and uninfected with HCMV (P > 0.050). GG homozygotic and GA heterozygotic status in TLR9 2848 G > A SNP decreased significantly the occurrence of HCMV infection (OR 0.44 95% CI 0.21–0.94 in the dominant model, P ≤ 0.050). The G allele in TLR9 SNP was significantly more frequent among the uninfected pregnant women than among the infected ones (χ2 = 4.14, P ≤ 0.050). Considering other polymorphisms, similar frequencies of distinct genotypes, haplotypes and multiple-SNP variants were observed between the studied groups of patients.Conclusions TLR9 2848 G > A SNP may be associated with HCMV infection in pregnant women.Electronic supplementary materialThe online version of this article (doi:10.1186/s12985-017-0730-8) contains supplementary material, which is available to authorized users.

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Awareness and knowledge of congenital cytomegalovirus infection among health care providers in France

Cited by 63 publications

References 19 publications

Management of Cytomegalovirus Seroconversion during Pregnancy in France

Management of Cytomegalovirus Seroconversion during Pregnancy in France

Analysis of risk factors associated to cytomegalovirus infection in dentistry students.

Toll-like receptors genes polymorphisms and the occurrence of HCMV infection among pregnant women

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