Awareness and education of patients receiving bisphosphonates

Bauer, Júlia; Beck, Nina; Kiefer, Julia; Stockmann, Philipp; Wichmann, Manfred; Eitner, Stephan

doi:10.1016/j.jcms.2011.04.011

Cited by 35 publications

(41 citation statements)

References 34 publications

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“…BRONJ can occur in patients receiving BPs therapy and appears to be associated with previous dental traumatic injury; however, spontaneous occurrence has also been observed [6, 10–13]. Most of the incidences of BRONJ have been reported as a result of intravenous administration of high doses of aminobisphosphonates [14, 15], ranging from 0.8% to 12% [16, 17], whereas association of BRONJ and non-nitrogen BP is very rare [18], ranging from 0.01 to 0.34% [16, 17]. The risk of BRONJ development rises in the presence of long duration of BPs exposure, concomitant treatment with corticosteroids [19–21], chemotherapies [22, 23], antiangiogenic drugs [24–26], and hormone therapy or in the presence of patient comorbidities such as immunodeficiency, diabetes mellitus, obesity, hypercholesterolemia, and parodontopathies.…”

Section: Introductionmentioning

confidence: 99%

New Dimensional Staging of Bisphosphonate-Related Osteonecrosis of the Jaw Allowing a Guided Surgical Treatment Protocol: Long-Term Follow-Up of 266 Lesions in Neoplastic and Osteoporotic Patients from the University of Bari

Franco

Miccoli

Limongelli

et al. 2014

International Journal of Dentistry

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Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is the most serious side effect in patients receiving bisphosphonates (BPs) for neoplastic disease and osteoporosis. The aim of this study is to propose a new dimensional stage classification, guiding the surgical treatment of BRONJ patients, and to evaluate the success rate of this new management. From 2004 to 2013, 203 neoplastic and osteoporotic patients with 266 BRONJ lesions were referred to the Odontostomatology Unit of the University of Bari. All patients underwent surgery after suspension of BPs therapy and antibiotic treatment. The surgical procedure was complemented by piezosurgery and followed by the application of hyaluronate and amino acids. The new dimensional staging suggests the choice of the surgical approach, and allows the prediction of postoperative complications and soft and hard tissues healing time, guiding the surgical treatment protocol. This protocol could be a successful management strategy for BRONJ, considering the low recurrences rate and the good stabilisation of the surgical sites observed after a long-term follow-up.

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Section: Introductionmentioning

confidence: 99%

New Dimensional Staging of Bisphosphonate-Related Osteonecrosis of the Jaw Allowing a Guided Surgical Treatment Protocol: Long-Term Follow-Up of 266 Lesions in Neoplastic and Osteoporotic Patients from the University of Bari

Franco

Miccoli

Limongelli

et al. 2014

International Journal of Dentistry

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“…They require regular control visits to check the state of the oral cavity, as well as preventive and conservative treatment. 21 The algorithm for patients with diagnosed BRONJ depends on the severity of the disease. There are 3 degrees of severity.…”

Section: Discussionmentioning

confidence: 99%

Bone necrosis associated with the use of bisphosphonates: Case report

Jachewicz¹,

Jakiel²

2017

Dent. Med. Probl.

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The aim of this study was to present the case of a 68-year-old female patient with jaw bone necrosis associated with the use of bisphosphonates. The case was qualified for the second degree of severity (BRONJ). The study demonstrates a multi-month observation of the patient and describes the sequestrectomy procedure performed, which was supplemented by covering the bone tissue with a collagen sponge. The treatment applied was slightly different from the accepted algorithms of proceedings. The difference was connected with the use of a collagen sponge containing gentamicin (used to cover the bone's surface) after the sequestrectomy. The collagen material, in contrast to the exposed dead bone, is a surface which may be susceptible to epithelization. This gives a possibility to the secondary closing of the wound as a result of granulation and epithelization without the bone's re-exposure. Moreover, the study characterizes indications for the use of bisphosphonates, their chemical structure and mechanism of action. It shows the definition of BRONJ (bisphosphonate-related osteonecrosis of the jaw) and risk factors for its occurrence, as well as prevention and treatment methods.

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“…Less often it may develop spontaneusly or as a result of chronic trauma to the oral mucosa, often caused by ill-fitting dentures 21 . Adverse effects and possible risks should be explained to the patient by the prescribing physician before the therapy onset aand dental preventive measures should be taken 22 . Patients in whom intravenous administration of high doses of bisphosphonates is planned are at higher risk of BRONJ development.…”

Section: Discussionmentioning

confidence: 99%