Awareness and attitudes towards clinical trials among Polish oncological patients who had never participated in a clinical trial

Staniszewska, Anna; Lubiejewska, Adriana; Czerw, Aleksandra; Dąbrowska-Bender, Marta; Duda-Zalewska, Aneta; Olejniczak, Dominik; Juszczyk, Grzegorz; Bujalska‐Zadrożny, Magdalena

doi:10.17219/acem/68762

Cited by 9 publications

(7 citation statements)

References 4 publications

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“…Knowledge, attitudes and experience related to clinical research, particularly randomized controlled clinical trials (RCT), are recognised as the best approach to reach hard, reproducible results, are not widely found among lay people and participants [17,18], especially ovarian cancer patients, despite fruitful research in this area. Ovarian cancer is the 10th female tumor, and still one of the biggest killers, with high mortality: five-year survival does not exceed 40%, 31% at ten years [19].…”

Section: Introductionmentioning

confidence: 99%

Knowledge and attitudes towards clinical trials among women with ovarian cancer: results of the ACTO study

et al. 2022

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Background Despite several initiatives by research groups, regulatory authorities, and scientific associations to engage citizens/patients in clinical research, there are still obstacles to participation. Among the main discouraging aspects are incomplete understanding of the concepts related to a clinical trial, and the scant, sometimes confused, explanations given. This observational, cross-sectional multicenter study investigated knowledge, attitudes and trust in clinical research. We conducted a survey among women with ovarian cancer at their first follow-up visit or first therapy session, treated in centers belonging to the Mario Negri Gynecologic Oncology (MaNGO) and Multicenter Italian Trials in Ovarian Cancer (MITO) groups. A questionnaire on knowledge, attitudes and experience was assembled ad hoc after a literature review and a validation process involving patients of the Alliance against Ovarian Cancer (ACTO). Results From 25 centers 348 questionnaire were collected; 73.5% of responders were 56 years or older, 54.8% had a high level of education, more than 80% had no experience of trial participation. Among participants 59% knew what clinical trials were and 71% what informed consent was. However, more than half did not know the meaning of the term randomization. More than half (56%) were in favor of participating in a clinical trial, but 35% were not certain. Almost all responders acknowledged the doctor’s importance in decision-making. Patients’ associations were recognized as having a powerful role in the design and planning of clinical trials. Conclusions This study helps depict the knowledge and attitudes of women with ovarian cancer in relation to clinical trials, suggesting measures aimed at improving trial “culture”, literacy and compliance, and fresh ways of communication between doctors and patients.

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Section: Introductionmentioning

confidence: 99%

Knowledge and attitudes towards clinical trials among women with ovarian cancer: results of the ACTO study

et al. 2022

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“…These barriers are common ones that prevent participation in clinical studies in general. [29][30][31][32] For example, a study that was conducted among rural and urban communities showed that fear, side-effects, limited understanding, limited time, and mistrust were common barriers that prevented participation in clinical studies. 33 According to study findings, willingness to be enrolled in COVID-19 vaccine clinical trials was associated with educational level and participation in a previous clinical study.…”

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confidence: 99%

<p>Public Willingness to Participate in COVID-19 Vaccine Clinical Trials: A Study from Jordan</p>

Farha

Alzoubi

Khabour

2020

PPA

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Purpose The development and production of novel vaccine to prevent COVID-19 is an international imperative to human lives. For that purpose, clinical trials have to be carried out as per international ethical standards. The current study was undertaken to examine the willingness to participate in COVID-19 vaccine clinical trials and to determine factors that might affect their decision to participate. Patients and Methods A cross-sectional survey study was carried out among the public in Jordan. During the study period, a convenience sample of adults (aged 18 years or above) were asked to participate via an online self-administered survey that was designed to evaluate the willingness to participate in COVID-19 vaccine clinical trials and to determine factors affecting their decision to participate. Results Results showed that, among participants (n=1,287), 36.1% reported to be willing to participate in clinical trials of the vaccine. Additionally, a lower percentage (18.1%) were willing to allow their children to participate. Motivators that encourage participation were the desire to return to normal life (73.2%), followed by the desire to help in finding a treatment for COVID-19 infection (68.1%). Barriers towards the participation were not wanting to be challenged by the virus (54.7%), fear (40.7%), lack of time (40.4%), and mistrust in pharmaceutical companies (38.9%). Finally, results showed that higher educational level was associated with lower willingness to participate ( P =0.001), whereas having a previous participation in clinical studies is associated with a significantly higher willingness to participate in COVID-19 vaccine clinical trials ( P <0.001). Conclusion A good portion of Jordanians are positive regarding participation in clinical studies of COVID-19 vaccine. Educational level and previous participation in clinical studies were among the determinants of such willingness. In addition, fear and lack of time were among the barriers of participation.

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“…According to the survey, 86.5% of respondents had previously heard of clinical trials. Referring to a 2018 article, which also surveyed Poles' awareness of clinical trials (with 284 respondents), it was shown that at that time 69.9% of respondents were aware of clinical trials [13]. The differences in results between that and the current survey can be understood in the context of the passage of time.…”

Section: Discussionmentioning

confidence: 58%

Knowledge and Beliefs of Clinical Trials Among Adults in Poland

Cięszczyk,

Czech,

Gujski

et al. 2024

Preprint

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Background: Clinical trials, by contributing to the development of diagnostics and to the search for modern, more effective, and safer therapies, have become one of the most important elements of the healthcare system. The aim of this study was to assess Poles' knowledge and beliefs about clinical trials. Methods: The survey was conducted among Poles aged 18 and over with the help of external company. The questionnaire contained 22 questions, of which 13 questions concerned beliefs and attitudes towards clinical trials. Results: Data were obtained from 1079 Poles (52.6% women). Among the respondents, 86.5% were aware of clinical trials. The main source of information about clinical trials was the media (53.8%) including the Internet (32.9%) and TV (16.2%). 43.2% of respondents reported little knowledge of clinical trials, while more than three quarters (75.2%) said they would like to learn more about clinical trials. Most respondents (81.4%) agreed with the statement that participation in a clinical trial is completely voluntary, and more than half (53.7%) agreed with the statement that hospitals participating in clinical trials provide better healthcare. The statement that the results of clinical trials are made available to the public was disagreed with by 37.2% of participants. Only 30.3% of participants agreed that clinical trials should be conducted with children. Conclusions: Poles rate their knowledge of clinical trials as low and would like to learn more. To reach the largest possible group of Polish patients, parallel educational activities on multiple levels may have the best effect. Poles' knowledge of clinical trials is mainly based on commercial sources. Further studies in different groups, i.e., clinical trial patients and investigators, are needed.

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Awareness and attitudes towards clinical trials among Polish oncological patients who had never participated in a clinical trial

Cited by 9 publications

References 4 publications

Knowledge and attitudes towards clinical trials among women with ovarian cancer: results of the ACTO study

Knowledge and attitudes towards clinical trials among women with ovarian cancer: results of the ACTO study

<p>Public Willingness to Participate in COVID-19 Vaccine Clinical Trials: A Study from Jordan</p>

Knowledge and Beliefs of Clinical Trials Among Adults in Poland

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