Awareness Among College Students Towards Covid-19 and its Effects on the Cardiovascular System - A Survey

Harini, Melinda; Devi, Gayatri; Gayathri, R.

doi:10.31782/ijcrr.2020.sp05

Cited by 3 publications

(2 citation statements)

References 4 publications

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“…Highly successful strategies for controlling HCM have emerged, altering the clinical course and substantially decreasing mortality and disability rates. These advancements [8,9] highlight the significance of accurate HCM diagnosis by cardiac magnetic resonance imaging and echocardiography. The GPAT/AGPAT family of enzymes is currently seeing a surge in discoveries.…”

Section: Introductionmentioning

confidence: 99%

Determining the Role of Caffeic Acid on Lipogenic Regulators: An In-Silico Approach

Fathima A,

Renu,

Vishnu Priya

et al. 2024

TIJPH

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In this study we have used a computational method to investigate how caffeic acid affects important regulators in lipid metabolism, such as the DGAT, GPAT, and PAP genes. Studying how natural substances interact with important regulatory genes is key to understanding lipid metabolism, especially in the setting of metabolic diseases such as diabetes and obesity. We used molecular docking to find out how strongly caffeic acid binds to lipogenic regulators and how these regulators interact with each other. The findings indicate that caffeic acid can directly affect DGAT, GPAT, and PAP. We used predictive models to assess how caffeic acid-binding may influence enzyme activity, gene expression, and signalling pathways related to lipid metabolism. Our computer results give us important information about how caffeic acid might affect lipid metabolism (DGAT, GPAT, and PAP), but it is very important to stress that these interactions and their importance in the body need to be confirmed in experiments. In conclusion, because cellular and metabolic processes are so complicated, it is important to do both in vitro and in vivo studies to fully understand how caffeic acid affects lipid balance and how it might be used to treat metabolic diseases. This study establishes the foundation for the next research, highlighting the capacity of natural chemicals to impact crucial regulators of lipid metabolism.

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Section: Introductionmentioning

confidence: 99%

Determining the Role of Caffeic Acid on Lipogenic Regulators: An In-Silico Approach

Fathima A,

Renu,

Vishnu Priya

et al. 2024

TIJPH

View full text Add to dashboard Cite

show abstract

“…However, chronic inflammation may develop in some clinical conditions, such as obesity, even without infection or damage [4]. Diseases including cancer, cardiovascular disease [5], diabetes [6][7][8], and asthma are significantly impacted by inflammation. Diet may affect several stages of inflammation, hence influencing specific inflammatory diseases.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Aspalathin on SMAD2, SMAD3, TGF-β - A Major Contributor of Inflammation – An In-silico Approach

A.G,

Renu,

Vishnu Priya

et al. 2024

TIJPH

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Chronic inflammation plays a crucial role in the development of several illnesses, and the transforming growth factor-beta (TGF-β) pathway, including SMAD2 and SMAD3, regulates inflammatory responses. Aspalathin, a naturally-occurring compound extracted from several plant sources, has shown potential anti-inflammatory properties. This study uses computational methods to investigate how aspalathin affects SMAD2, SMAD3, and TGF-β in order to understand how it regulates inflammation. We use molecular docking to analyze how aspalathin binds with important components of the TGF-β pathway. Our research reveals promising information about the potential of aspalathin, which shows a strong ability to bind with the inflammatory regulator (SMAD2, SMAD3, and TGF-β). Aspalathin may offer therapeutic benefits for treating inflammatory diseases. Further testing in both controlled laboratory environments (in vitro) and inside live creatures (in vivo) are required to validate the computational findings and prove aspalathin's potential as a viable option for inflammation management.

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Correlation of Diabetic Status and Coronavirus Disease 2019 (COVID-19) in Patients With Mucormycosis: A Retrospective Clinical Study

Pillai

2023

Cureus

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Aim: Coronavirus disease 2019 (COVID-19) and its association with diabetes might lead to mucormycosis, and studies have reported an association between them. This study aims to find the correlation between COVID-19 and diabetic status in patients with mucormycosis and its role in disease progression and prognosis. The objectives of the study are to analyze the clinical range of mucormycosis in those with diabetes and COVID-19 and to correlate the clinical and radiographic findings. Materials and methodology: A retrospective cohort analysis was carried out at Saveetha Dental College and Hospitals in Chennai (approval number: IHEC/SDC/OMED-2204/23/218). The data collection was done from the institution's electronic database from April 2019 to April 2023 which included the patients' age and gender and COVID-19 and diabetic status and clinical and radiographic features of mucormycosis. Results: From the data analyzed, 25 patients had a history of mucormycosis with diabetes and COVID-19 infections. The patients' average age was 47.76, out of which 22 were males and three were females. The chi-squared test showed no significant association between age (0.178), diabetes (0.465), and COVID-19 (0.583). Spearman's correlation was done showing an association between mucormycosis, diabetes, and COVID-19. Radiographically, 100% of the patients had involvement of the maxillary sinus, followed by the palate (32%), orbit (28%), nasal floor (24%), ethmoidal sinus (16%), sphenoidal sinus (12%), and frontal sinus (8%). Conclusion: The findings of this study point out the importance of considering the presence of systemic comorbidities like diabetes in COVID-19 patients. Early identification, surgical debridement, and antifungal medications are part of the treatment for increased survival.

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Awareness Among College Students Towards Covid-19 and its Effects on the Cardiovascular System - A Survey

Cited by 3 publications

References 4 publications

Determining the Role of Caffeic Acid on Lipogenic Regulators: An In-Silico Approach

Determining the Role of Caffeic Acid on Lipogenic Regulators: An In-Silico Approach

The Effect of Aspalathin on SMAD2, SMAD3, TGF-β - A Major Contributor of Inflammation – An In-silico Approach

Correlation of Diabetic Status and Coronavirus Disease 2019 (COVID-19) in Patients With Mucormycosis: A Retrospective Clinical Study

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