Awakening

Andrasik, Michele P.; Maunakea, Alika K.; Oseso, Linda; Rodríguez-Díaz, Carlos E.; Wallace, Stephaun E; Walters, Karina L.; Yukawa, Michi

doi:10.1016/j.idc.2022.01.009

Cited by 18 publications

(3 citation statements)

References 44 publications

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“…It is clear that race/ethnicity is a valid and critical risk marker for other underlying conditions affecting the complexity of COVID-19 disease, such as structural racism, discrimination and socioeconomic status, [ 70 ] lack of health care access, [ 71 ] and exposure to infectious agents related to high risk and service industry occupations [ 72 ]. Although one can never be confident that all confounding factors have been adjusted properly, Williamson et al [ 2 ] showed that ethnicity among a very large cohort in England was associated with COVID-19 outcomes, even after adjusting for socioeconomic factors.…”

Section: Discussionmentioning

confidence: 99%

Genetic variant rs1205 is associated with COVID-19 outcomes: The Strong Heart Study and Strong Heart Family Study

Best,

Erdei,

Haack

et al. 2024

PLoS ONE

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Background Although COVID-19 infection has been associated with a number of clinical and environmental risk factors, host genetic variation has also been associated with the incidence and morbidity of infection. The CRP gene codes for a critical component of the innate immune system and CRP variants have been reported associated with infectious disease and vaccination outcomes. We investigated possible associations between COVID-19 outcome and a limited number of candidate gene variants including rs1205. Methodology/Principal findings The Strong Heart and Strong Heart Family studies have accumulated detailed genetic, cardiovascular risk and event data in geographically dispersed American Indian communities since 1988. Genotypic data and 91 COVID-19 adjudicated deaths or hospitalizations from 2/1/20 through 3/1/23 were identified among 3,780 participants in two subsets. Among 21 candidate variants including genes in the interferon response pathway, APOE, TMPRSS2, TLR3, the HLA complex and the ABO blood group, only rs1205, a 3’ untranslated region variant in the CRP gene, showed nominally significant association in T-dominant model analyses (odds ratio 1.859, 95%CI 1.001–3.453, p = 0.049) after adjustment for age, sex, center, body mass index, and a history of cardiovascular disease. Within the younger subset, association with the rs1205 T-Dom genotype was stronger, both in the same adjusted logistic model and in the SOLAR analysis also adjusting for other genetic relatedness. Conclusion A T-dominant genotype of rs1205 in the CRP gene is associated with COVID-19 death or hospitalization, even after adjustment for relevant clinical factors and potential participant relatedness. Additional study of other populations and genetic variants of this gene are warranted.

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Section: Discussionmentioning

confidence: 99%

Genetic variant rs1205 is associated with COVID-19 outcomes: The Strong Heart Study and Strong Heart Family Study

Best,

Erdei,

Haack

et al. 2024

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…It is clear that race/ethnicity is a valid and critical risk marker for other underlying conditions affecting the complexity of COVID-19 disease, such as structural racism, discrimination and socioeconomic status, [70] lack of health care access, [71] and exposure to infectious agents related to high risk and service industry occupations. [72] Although one can never be confident that all confounding factors have been adjusted…”

Section: Discussionmentioning

confidence: 99%

Genetic Variant rs1205 is Associated with COVID-19 Outcomes: The Strong Heart Study and Strong Heart Family Study

Best

Erdei

Haack

et al. 2023

Preprint

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Background: Although COVID-19 infection has been associated with a number of clinical and environmental risk factors, host genetic variation has also been associated with the incidence and morbidity of infection. The CRP gene codes for a critical component of the innate immune system and CRP variants have been reported associated with infectious disease and vaccination outcomes. We investigated possible associations between COVID-19 outcome and a limited number of candidate gene variants including rs1205. Methodology/Principal Findings: The Strong Heart and Strong Heart Family studies have accumulated detailed genetic, cardiovascular risk and event data in geographically dispersed American Indian communities since 1988. Chi-square tests, logistic regression and generalized linear mixed models (implemented in SOLAR) were used in analysis. Genotypic data and 91 COVID-19 adjudicated deaths or hospitalizations from 2/1/20 through 3/1/23 were identified among 3,780 participants in two subsets. Among 21 candidate variants including genes in the interferon response pathway, APOE, TMPRSS2, TLR3, the HLA complex and the ABO blood group, only rs1205, a 3' untranslated region variant in the CRP gene, showed nominally significant association in T-dominant model analyses (odds ratio 1.859, 95%CI 1.001-3.453, p=0.049) after adjustment for age, sex, center, body mass index, and a history of cardiovascular disease. Within the younger subset, association with the rs1205 T-Dom genotype was stronger, both in the same adjusted logistic model and in the SOLAR analysis also adjusting for other genetic relatedness. Conclusion: A T-dominant genotype of rs1205 in the CRP gene is associated with COVID-19 death or hospitalization, even after adjustment for relevant clinical factors and potential participant relatedness. Additional study of other populations and genetic variants of this gene are warranted.

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“…Other areas of inequality included race, those with pre-existing conditions, the immunocompromised, and persons living with physical or mental disabilities. Andrasik et al [12] write that: "For most infectious diseases, including COVID-19, the most extreme burden of disease is experienced by society's most vulnerable, most often, people who experience multiple forms of social disadvantage" (p. 297).…”

Section: Covid-19mentioning

confidence: 99%

An Agentic Familiarity: The Context of HIV/AIDS and Sexual Orientation for Older Canadians during the COVID-19 Pandemic

de Vries,

Gutman,

Beringer

et al. 2023

Healthcare

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This paper examines how experiences with a previous pandemic, particularly HIV/AIDS, may have informed approaches to COVID-19, with a focus on sexual orientation. Method: The sample was drawn from an online survey of Canadians 55+ conducted in 2020, comprising 1143 persons (mean age = 67; 88 gay or bisexual (GB) men, 65 lesbian or bisexual (LB) women, 818 heterosexual women, and 172 heterosexual men). Respondents reported if they, or someone close to them, “had been affected by” one or more pandemics and whether COVID-19 led them to “think more about their prior epidemic/pandemic experiences” and/or feel they “couldn’t handle it again”. Correlated items reflecting feeling “they have been here before”; “prepared for what is happening”; and “like they needed to act or do something” formed a scale named “agentic familiarity”. Results: About half of respondents reported thinking about their previous pandemic experience; about 5% reporting feeling like “they couldn’t handle it again” with no gender or sexual orientation differences. Higher agentic familiarity scores were found for GB men and for those with experience with HIV/AIDS vs. other pandemics. Discussion: These outcomes speak to resilience and growth experienced by LGBT (and especially GB) persons through shared stigma and trauma—with implications for current pandemic experiences and future actions, like advance care planning.

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Awakening

Cited by 18 publications

References 44 publications

Genetic variant rs1205 is associated with COVID-19 outcomes: The Strong Heart Study and Strong Heart Family Study

Genetic variant rs1205 is associated with COVID-19 outcomes: The Strong Heart Study and Strong Heart Family Study

Genetic Variant rs1205 is Associated with COVID-19 Outcomes: The Strong Heart Study and Strong Heart Family Study

An Agentic Familiarity: The Context of HIV/AIDS and Sexual Orientation for Older Canadians during the COVID-19 Pandemic

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