Awake brain surgery in children—a single-center experience

Lohkamp, Laura-Nanna; Beuriat, Pierre-Aurélien; Desmurget, Michel; Cristofori, Irène; Szathmari, A.; Huguet, Ludivine; Rocco, F. Di; Mottolèse, C.

doi:10.1007/s00381-020-04522-9

Cited by 20 publications

(18 citation statements)

References 33 publications

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“…It will lead to further language or motor dysfunction after surgery. Moreover, the prognosis of these patients is seriously affected, and their quality of life is reduced [ 2 ]. Therefore, how to remove tumors to the maximum extent under the premise of ensuring brain function is a common concern of surgeons.…”

Section: Introductionmentioning

confidence: 99%

The Efficacy of Remifentanil Combined with Propofol in Craniotomy for Tumor Was Evaluated by Wake Quality, Hemodynamics, and Adverse Reactions

Zhou

Han

Chen

2022

BioMed Research International

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In order to investigate the effect of remifentanil combined with propofol on awakening of craniotomy for tumor, a retrospective analysis is conducted. 86 patients who underwent craniotomy for brain tumor in our hospital from July 2020 to December 2021 are chosen to observe the quality of awakening, hemodynamic parameters, and the occurrence of adverse reactions. All patients are divided into group A ( n = 43 ) and group B ( n = 43 ) according to the use of anesthesia drugs. The intraoperative awakening quality and the hemodynamic parameters during different periods of the two groups are compared. The experimental results show that the incidence of postoperative adverse reactions in group B is significantly lower than that in group A ( P < 0.05 ). It is clearly evident that remifentanil combined with protocol has good intraoperative wake-up effect in craniotomy for tumor and maintain the hemodynamic stability of patients. Also, it can obtain high wake-up quality and effectively reduce postoperative adverse reactions.

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Section: Introductionmentioning

confidence: 99%

The Efficacy of Remifentanil Combined with Propofol in Craniotomy for Tumor Was Evaluated by Wake Quality, Hemodynamics, and Adverse Reactions

Zhou

Han

Chen

2022

BioMed Research International

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“…e operation risk of brain functional lesions is extremely high because the normal brain tissue is easy to be damaged in conventional operation. It can result in neurological impairment, which may involve the patients with language, sensory, or limb disorders after the operation [1]. e intraoperative wake-up technique is one of the important auxiliary techniques for brain functional area tumor resection.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Dexmedetomidine and Etomidate on Intraoperative Wake-Up Equality, Hemodynamics, and Cerebral Protection in Operation of the Brain Functional Area

Peng

Guan

2021

Evidence-Based Complementary and Alternative Medicine

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In recent years, with the increasing incidence of brain functional area tumors, the clinical application of functional area tumor resection has become extremely urgent. Intraoperative wake-up is an important auxiliary method of this operation, which can effectively reduce the damage of the brain function area caused by the operation and anesthesia itself while playing the role of auxiliary function area and tumor positioning. However, the intraoperative wake-up requires a higher anesthesia effect, so higher requirements are put forward for the choice of anesthetic drugs. Based on hemodynamic and serum molecular observations, this study found that dexmedetomidine- and etomidate-assisted anesthesia were used for intraoperative wake-up in brain functional area surgery, both of which could maintain hemodynamic stability. In addition, the arousal effect and brain protection of dexmedetomidine were better than those of etomidate, and the incidence of adverse reactions was lower during the arousal period. This can provide relevant reference for clinical improvement of the anesthesia effect and surgical safety of intraoperative wake-up.

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“…Awake craniotomy is usually performed in patients aged 15–65 years, although, awake craniotomy is not only specified by age ( 8 ). Recently, there have been some reports that awake craniotomy can be successfully performed for elderly and younger patients ( 9 – 11 ); however, the procedure can be difficult to apply for patients with severe aphasia, intellectual disability, or psychiatric disorders, and elderly and younger patients who cannot tolerate awake craniotomy ( 12 , 13 ). Furthermore, ECS has noteworthy limitations that include substantial time requirements ( 14 , 15 ) and an increased risk for induced pathological brain activity, such as after-discharges or seizures ( 16 , 17 ).…”

Section: Discussionmentioning

confidence: 99%

The Efficacy of Intraoperative Passive Language Mapping for Glioma Surgery: A Case Report

et al. 2021

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Background: Recently, electrocorticographic (ECoG) studies have emphasized the importance of gamma band-based functional mapping in the presurgical localization of the eloquent cortex. Passive functional mapping using ECoG signals provides a reliable method for identifying receptive language areas without many of the risks and limitations associated with electrical cortical stimulation. We report a surgical case of left temporal malignant glioma with intraoperative passive language mapping.Case Description: A 78-year-old woman was diagnosed with left temporal glioma with inspection of her language difficulty. MRI showed a left temporal tumor measuring 74.6 × 50.0 × 51.5 mm in size. Real-time CortiQ-based mapping using high-gamma activity by word-listening and story-listening tasks was performed. Significant listening task-evoked high gamma activities were detected in 5 channels in the superior temporal gyrus and one channel in the middle temporal gyrus. The tumor was grossly removed except for the region corresponding to listening task-evoked high gamma activities. Postoperatively, the patient's symptoms of language comprehension difficulty improved, and no new neurological deficits were observed.Conclusion: Intraoperative passive language mapping was successfully performed, and the patient's language function was well-preserved. Intraoperative passive language mapping, which is applicable in a short time and under general anesthesia, can be an important tool for detecting language areas.

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Awake brain surgery in children—a single-center experience

Cited by 20 publications

References 33 publications

The Efficacy of Remifentanil Combined with Propofol in Craniotomy for Tumor Was Evaluated by Wake Quality, Hemodynamics, and Adverse Reactions

The Efficacy of Remifentanil Combined with Propofol in Craniotomy for Tumor Was Evaluated by Wake Quality, Hemodynamics, and Adverse Reactions

Comparison of Dexmedetomidine and Etomidate on Intraoperative Wake-Up Equality, Hemodynamics, and Cerebral Protection in Operation of the Brain Functional Area

The Efficacy of Intraoperative Passive Language Mapping for Glioma Surgery: A Case Report

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