Avoiding sampling error in the biopsy of pigmented lesions

Stevens, G.L.; Cockerell, Clay J.

doi:10.1001/archderm.132.11.1380

Cited by 18 publications

(17 citation statements)

References 18 publications

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“…9 Based on observational findings, Stevens and Cockerell recommended a deep incisional biopsy along the skin lines deep into the subcutis; however, if a punch is to be used they recommended a diameter of at least 5 mm to be taken. 10 The majority of our patients had surgical treatment (84%). Although one patient who was treated with cryotherapy had a recurrence after 7 years, all patients treated with nonsurgical methods had an initial punch biopsy and none had any posttreatment histology.…”

Section: Review Of Management and Outcome Inmentioning

confidence: 91%

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Review of management and outcome in 65 patients with lentigo maligna

Al‐Niaimi

Jury

McLaughlin

et al. 2009

British Journal of Dermatology

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of observation a first cycle was performed in the upper part of the lesion. A good result was observed after 4-5 weeks in all cases (Fig. 1b). A second cycle was completed in the lower half of the lesion with a good aesthetic result (Fig. 1c).Usually no treatment is available for these patients; only cosmetic camouflage is offered. The alexandrite laser is a wellestablished treatment for epilation whose chromophore is References 1 Greagh TM, Wright NA, McKee PH. Inflamatory dermatoses. In: Pathology of the Skin, with Clinical Correlations (McKee PH, ed.). London: Gower Medical Publishing, 1989; 8.28. 2 Polla LL, Margollis RJ, Dover JS et al. Melanosomes are a primary target of Q-switched rugy laser irradiation in guinea pig skin. J Invest Dermatol 1987; 89:281-6. 3 Lanigan SW, Joannides T. Pulsed dye laser treatment of telangiectasia after radiotherapy for carcinoma of the breast. Br J Dermatol 2003; 148:77-9.

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Section: Review Of Management and Outcome Inmentioning

confidence: 91%

“…9 The management of LCH has been reviewed recently. 10 In general, localized disease is regarded as having a good prognosis and requires minimal treatment; those with lesions in…”

Section: Review Of Management and Outcome Inmentioning

confidence: 99%

Review of management and outcome in 65 patients with lentigo maligna

Al‐Niaimi

Jury

McLaughlin

et al. 2009

British Journal of Dermatology

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“…[58][59][60] Punch biopsy specimens are associated with a high rate of false-negative results. [61][62][63] In the authors' experience, selection of the darkest portion of the lesion identifies the area with greatest pigment incontinence but is not necessarily the most diagnostic portion of the lesion. A broad thin shave biopsy specimen resembling properly cut prosciutto can provide the pathologist with a broad view of the junctional melanocytic proliferation without creating a deep wound.…”

Section: Basal Cell Carcinoma/squamous Cell Carcinomamentioning

confidence: 99%

Skin biopsy

Elston

Stratman

Miller

2016

Journal of the American Academy of Dermatology

119

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Misdiagnosis may result from biopsy site selection, technique, or choice of transport media. Important potential sources of error include false-negative direct immunofluorescence results based on poor site selection, uninformative biopsy specimens based on both site selection and technique, and spurious interpretations of pigmented lesions and nonmelanoma skin cancer based on biopsy technique. Part I of this 2-part continuing medical education article addresses common pitfalls involving site selection and biopsy technique in the diagnosis of bullous diseases, vasculitis, panniculitis, connective tissue diseases, drug eruptions, graft-versus-host disease, staphylococcal scalded skin syndrome, hair disorders, and neoplastic disorders. Understanding these potential pitfalls can result in improved diagnostic yield and patient outcomes.

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“…Generally, incisional biopsy of melanoma is discouraged 9 but biopsies are commonly performed of LM to confirm the diagnosis, or to exclude the presence of invasive melanoma if a non‐surgical treatment option is planned. It is recommended that the biopsy should include the darkest and/or thickest area of the lesion 10 . However, sampling problems are perceived to be of particular importance for LM, and in one study incisional biopsies failed to identify microinvasive melanoma subsequently demonstrated in the full excision specimen 11 .…”

Section: Discussionmentioning

confidence: 99%

Survey of U.K. current practice in the treatment of lentigo maligna

Newton-Bishop

2001

British Journal of Dermatology

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This survey highlights that a significant proportion of U.K. dermatologists is managing small numbers of LMs each year. On the basis of this current practice and the data in the literature on the recurrence rates for the different modalities, we propose an algorithm for treatment options. The survey, however, showed no consensus between dermatologists regarding surgical margins for excision, which is reflected in the literature; further studies to establish this are required.

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Avoiding sampling error in the biopsy of pigmented lesions

Cited by 18 publications

References 18 publications

Review of management and outcome in 65 patients with lentigo maligna

Review of management and outcome in 65 patients with lentigo maligna

Skin biopsy

Survey of U.K. current practice in the treatment of lentigo maligna

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