A 32-year-old woman, gravida 6 para 5004, at 37 0/7 weeks of gestation presented for a repeat cesarean delivery. The patient's pregnancy was complicated by morbid obesity (body mass index [calculated as weight (kg)/[height (m)] 2 ] 53.1), chronic hypertension, and obstructive sleep apnea (OSA) but not pregestational or gestational diabetes. Her antenatal course was uneventful. Her OSA was diagnosed 2 years before this pregnancy but she failed to initiate therapy. A repeat polysomnogram performed at 20 weeks confirmed her OSA with an apnea-hypopnea index of nine events per hour, indicating mild sleep apnea. Her lowest oxygen saturation on the overnight polysomnogram was 76% and she spent 3.9% of her total sleep time with an SpO 2 level less than 90%. After multiple visits for evaluation and continuous positive airway pressure (CPAP) adjustment, she initiated CPAP treatment at 12 cm H 2 O at 26 weeks of gestation. She reported nightly compliance thereafter.The patient underwent an uncomplicated repeat cesarean delivery and a tubal ligation under combined spinalepidural (12 mg bupivacaine, 20 g fentanyl, 0.2 mg morphine). The neonate weighed 3,148 grams and Apgar scores at 1 and 5 minutes were 9 and 9, respectively. Secondary to our departmental postoperative sleep apnea protocol ( Fig. 1), she was monitored on labor and delivery for 24 hours after her cesarean delivery. The patient declined CPAP. Within the first 4 hours postoperatively, the patient was noted to have intermittent hypoxemia with a pulse oximetry nadir of 83%. At that time, her lungs were clear, there was no tachycardia, and she denied chest pain. Therefore, venous thromboembolism or pulmonary edema was deemed unlikely. Subsequently, her pulse oximetry ranged between 93% and 94%. Given her sleep apnea, she was kept on continuous pulse oximetry monitoring for the remainder of her admission. No narcotics beyond the spinal narcotics administered by anesthesia intraoperatively could be administered for the first 24 hours without permission from the anesthesia service (per our neuraxial opioid standing orders). There were no standing orders for opioid medications (intravenous or oral) in the postoperative period beyond 24 hours. Rather, physician assessment of vital signs was required before narcotic administration and ketorolac was used for analgesia. The hypoxemia was most profound in the first 24 hours. On postoperative day 2, her oxygen saturation was consistently approximately 96% with a nadir of 93%. By postoperative day 3, the patient's pulse oximetry returned back to her preoperative baseline of 98% with no desaturations (on room air). Given her long-standing history of sleep apnea, an echocardiogram was performed to evaluate for the presence of pulmonary hypertension and was noted to be normal. The remainder of the patient's course was uneventful and she was discharged home on postoperative day 4.Obstructive sleep apnea is a sleep-related breathing disorder that is characterized by recurrent episodes of partial (hypopnea) or complete (apnea) airw...