Avoidance of recurrence of CRPS Type 1 in individuals requiring further surgery for Dupuytren's contracture

Dam, Helena Van; Elliot, David

doi:10.1016/j.bjps.2013.12.024

Cited by 4 publications

(5 citation statements)

References 3 publications

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“…Amongst the best examples is Complex Regional Pain Syndrome (CRPS) which can reoccur following re-injury (e.g., following surgery (Ackerman and Ahmad, 2008; Van Dam and Elliot, 2014)), suggesting a preordained state. Brain imaging studies in children report altered networks for the previously affected vs. unaffected limb, even after the pain has disappeared (Lebel et al, 2008).…”

Section: When Pain Pops Out To Conscious Awareness – Insights Frommentioning

confidence: 99%

Subliminal (latent) processing of pain and its evolution to conscious awareness

Borsook

Youssef

Barakat

et al. 2018

Neuroscience & Biobehavioral Reviews

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By unconscious or covert processing of pain we refer to nascent interactions that affect the eventual deliverance of pain awareness. Thus, internal processes (viz., repeated nociceptive events, inflammatory kindling, re-organization of brain networks, genetic) or external processes (viz., environment, socioeconomic levels, modulation of epigenetic status) contribute to enhancing or inhibiting the presentation of pain awareness. Here we put forward the notion that for many patients, ongoing sub-conscious changes in brain function are significant players in the eventual manifestation of chronic pain. In this review, we provide clinical examples of nascent or what we term pre-pain processes and the neurobiological mechanisms of how these changes may contribute to pain, but also potential opportunities to define the process for early therapeutic interventions.

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Section: When Pain Pops Out To Conscious Awareness – Insights Frommentioning

confidence: 99%

Subliminal (latent) processing of pain and its evolution to conscious awareness

Borsook

Youssef

Barakat

et al. 2018

Neuroscience & Biobehavioral Reviews

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“…Myofibroblasts are known to be the key cells responsible for both contraction and extracellular matrix deposition, but the initiating event causing myofibroblast proliferation is unresolved. Numerous published studies support various treatment modalities for potentially effective treatment of Dupuytren's disease by regulating contractile myofibroblasts . However, its pathogenesis remains largely obscure .…”

Section: Introductionmentioning

confidence: 99%

“…Numerous published studies support various treatment modalities for potentially effective treatment of Dupuytren's disease by regulating contractile myofibroblasts. [2][3][4][5][6][7][8][9][10] However, its pathogenesis remains largely obscure. 11 Only over the past 30 years, many researchers suggest a strong genetic heritance in Dupuytren's disease.…”

Section: Introductionmentioning

confidence: 99%

A meta‐analysis to identify novel diagnostic and therapeutic targets for Dupuytren's disease

Park

Kim

Lee

et al. 2019

Wound Repair Regeneration

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The aim of this study was to determine novel candidate genes for Dupuytren's disease by performing a meta‐analysis. We identified 261 genes (111 up‐regulated and 150 down‐regulated) that were consistently expressed differentially in Dupuytren's disease across the studies. We performed functional enrichment on total sets of the identified 261 genes and confirmed that most of the genes were closely related to common processes of diseases in general. From the integrated studies of the gene‐correlation network and the protein–protein interaction network, we identified three functional modules in the gene co‐expression network and four hub gene clusters in the protein–protein interaction network that shared the same genes and represented similar biological functions, implying that the seven groups identified in the systematic analysis of these two networks might be involved in the pathogenesis of Dupuytren's disease. This work demonstrates potential in developing experimental and clinical strategies for understanding and treating Dupuytren's disease.

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“…Somit ergeben sich auch immer wieder Situationen, in denen abgewogen werden muss, ob eine erneute handchirurgische Operation einem Patienten mit stattgehabtem oder noch vorhandenem Schmerzsyndrom zugemutet werden kann. Die klassische Lehrmeinung besagt, bei CRPS-Patienten möglichst von operativen Interventionen abzusehen [3]. Wenn unvermeidlich, sind diverse Maßnahmen zur Vermeidung eines CRPS-Rezidives beschrieben worden [4].…”

Section: Introductionunclassified

“…Ergebnisse In der Interventionsgruppe betrug das durchschnittliche Schmerzniveau 105 Tage nach der letzten Operation 6,4 (4-8) auf der visuellen Analogskala (VAS; 0 bis 10), der durchschnittliche Fingerkuppenhohlhandabstand 3,2 (0-7,6) cm, der Bewegungsumfang des Handgelenkes 47,5 (0-95) ° und die Griffkraft 9,2 (2,(1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)6) kg. In der Kontrollgruppe betrug das durchschnittliche Schmerzniveau 129 Tage nach der letzten Operation 6 (3-10) auf der visuellen Analogskala, der durchschnittliche Fingerkuppenhohlhandabstand 2,7 (0-4,5) cm, der Bewegungsumfang des Handgelenkes 64 (0-125) °, die Griffkraft 12,4 (0,[8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23]8) kg.…”

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Prophylaktische Plexuskatheterbehandlung bei operativen Eingriffen nach Komplexem Regionalen Schmerzsyndrom (CRPS)

Neubrech

Pronk

Bigdeli

et al. 2017

Handchir Mikrochir plast Chir

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This paper investigates and discusses the effect of perioperative plexus catheter treatment in former CRPS patients. A retrospective matched-pair analysis was conducted on 10 CRPS patients with comparable injuries, who underwent surgery in the disease-free interval. In 10 cases, the procedure was performed with perioperative plexus catheter treatment (intervention group), whereas 10 patients did not receive perioperative plexus catheter treatment (control group). In the intervention group, after a follow-up time of 105 (20-184) days after the last surgical procedure, pain intensity on the visual analogue scale (VAS; 0 to 10) was 6.4 (4-8), fingertip-to-palm distance averaged 3.2 (0-7.6) cm, active range of wrist motion was 47.5 (0-95), and grip strength was 9.2 (2.1-16.6) kg. In the control group, after a follow-up time of 129 (19-410) days since the last surgical procedure, pain intensity on the visual analogue scale was 6 (3-10), fingertip-to-palm distance averaged 2.7 (0-4.5) cm, active range of wrist-motion was 64 (0-125), and grip strength was 12.4 (0.8-23.8) kg. There was no significant difference between the groups. There was no recurrence of CRPS disease in either group after surgery. There is no evidence so far for perioperative plexus catheter treatment to prevent recurrence in former CRPS patients.

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Avoidance of recurrence of CRPS Type 1 in individuals requiring further surgery for Dupuytren's contracture

Cited by 4 publications

References 3 publications

Subliminal (latent) processing of pain and its evolution to conscious awareness

Subliminal (latent) processing of pain and its evolution to conscious awareness

A meta‐analysis to identify novel diagnostic and therapeutic targets for Dupuytren's disease

Prophylaktische Plexuskatheterbehandlung bei operativen Eingriffen nach Komplexem Regionalen Schmerzsyndrom (CRPS)

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