Avocado seeds (Persea americana Mill.) prevents indomethacin-induced gastric ulcer in mice

Athaydes, Brena Ramos; Alves, Gisele Maziero; Assis, Arícia Leone Evangelista Monteiro de; Gomes, João Victor Dutra; Rodrigues, Rossana Lott; Campagnaro, Bianca Prandi; Nogueira, Breno Valentim; Silveira, Dâmaris; Kuster, Ricardo Machado; Pereira, Thiago de Melo Costa; Kitagawa, Rodrigo Rezende; Gonçalves, Rita de Cássia Ribeiro

doi:10.1016/j.foodres.2018.10.057

Cited by 53 publications

(41 citation statements)

References 39 publications

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“…In vivo studies performed by Athaydes et al [61] demonstrated that avocado seed extracts with ethyl acetate have gastroprotective activity and can be used as an adjunctive treatment for indomethacin-induced gastric mucosal injury. Uchenna et al [145] have shown promising component values in avocado seeds as a source of energy, protein, and bioactive phytochemicals to stimulate growth and metabolism.…”

Section: Fruit By-products (Seeds): Chemical Characterization and mentioning

confidence: 99%

“…In the same line of research, Dorta et al [40] assessed the effects of EtOH, water, and acetone as solvents and different temperatures on the extraction of antioxidants from mango peel and seeds. Table 1 contains some studies [15,28,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69] regarding the extraction of bioactive compounds from fruit seeds and the bioactivity already studied. It is clear that new studies regarding fruit seeds should be focused on the optimization of extraction conditions and on the extraction techniques so that new value-added extracts can be potentially used as ingredients by pharmaceutical and food sectors.…”

Section: Introductionmentioning

confidence: 99%

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Fruit Seeds as Sources of Bioactive Compounds: Sustainable Production of High Value-Added Ingredients from By-Products within Circular Economy

et al. 2019

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The circular economy is an umbrella concept that applies different mechanisms aiming to minimize waste generation, thus decoupling economic growth from natural resources. Each year, an estimated one-third of all food produced is wasted; this is equivalent to 1.3 billion tons of food, which is worth around US$1 trillion or even $2.6 trillion when social and economic costs are included. In the fruit and vegetable sector, 45% of the total produced amount is lost in the production (post-harvest, processing, and distribution) and consumption chains. Therefore, it is necessary to find new technological and environmentally friendly solutions to utilize fruit wastes as new raw materials to develop and scale up the production of high value-added products and ingredients. Considering that the production and consumption of fruits has increased in the last years and following the need to find the sustainable use of different fruit side streams, this work aimed to describe the chemical composition and bioactivity of different fruit seeds consumed worldwide. A comprehensive focus is given on the extraction techniques of water-soluble and lipophilic compounds and in vitro/in vivo functionalities, and the link between chemical composition and observed activity is holistically explained.

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Section: Fruit By-products (Seeds): Chemical Characterization and mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Fruit Seeds as Sources of Bioactive Compounds: Sustainable Production of High Value-Added Ingredients from By-Products within Circular Economy

et al. 2019

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“…This is due to the concerns of the consumers regarding the safety of products containing synthetic chemicals and their associated health risks [174]. Seeds (endocarp) and peels (exocarp) being the by-products of the avocado industry are generally disposed of as wastes [175] and have been investigated for their antimicrobial properties. Most of the studies conducted thus far have noted the antimicrobial activity of the extracts derived from different avocado varieties [104,176,177,178], while only a few have reported insignificant antimicrobial activity [101,179].…”

Section: Introductionmentioning

confidence: 99%

The Odyssey of Bioactive Compounds in Avocado (Persea americana) and Their Health Benefits

et al. 2019

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Persea americana, commonly known as avocado, has recently gained substantial popularity and is often marketed as a “superfood” because of its unique nutritional composition, antioxidant content, and biochemical profile. However, the term “superfood” can be vague and misleading, as it is often associated with unrealistic health claims. This review draws a comprehensive summary and assessment of research performed in the last few decades to understand the nutritional and therapeutic properties of avocado and its bioactive compounds. In particular, studies reporting the major metabolites of avocado, their antioxidant as well as bioavailability and pharmacokinetic properties, are summarized and assessed. Furthermore, the potential of avocado in novel drug discovery for the prevention and treatment of cancer, microbial, inflammatory, diabetes, and cardiovascular diseases is highlighted. This review also proposes several interesting future directions for avocado research.

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“…Anti-inflammatory potential of avocado peel and seed extracts was reported to suppress the release of tumor necrosis factor-α and generation of nitric oxide in lipopolysaccharide-stimulated RAW264.7 macrophages (Tremocoldi et al, 2018). Gastroprotective activity was reported for avocado seeds extract against indomethacin-induced gastric ulcer in mice (Athaydes et al, 2019). Polyphenols extracted from orange flesh and peel were shown to protect human leukocytes against oxidative DNA damage and HepG2 cells against peroxyl radical-induced oxidation in vitro (Park et al, 2014).…”

Section: Therapeutic Properties Of Active Compounds From Fruits By-prmentioning

confidence: 99%

Fruits By-Products – A Source of Valuable Active Principles. A Short Review

Fierăscu

Sieniawska

Orţan

et al. 2020

Front. Bioeng. Biotechnol.

106

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The growing demand for more sustainable, alternative processes leading to production of plant-derived preparations imposes the use of plants waste generated mainly by agri-food and pharmaceutical industries. These mostly unexploited but large quantities of plants waste also increase the interest in developing alternative approaches for sustainable production of therapeutic molecules. In order to reduce the amount of plant waste by further processing, different novel extraction techniques can be applied. Fruits and their industrial by-products are rich sources of different classes of compounds with therapeutic properties. The processed fruits waste can be reused and lead to novel pharmaceuticals, food supplements or functional foods. This review intends to briefly summarize recent aspects regarding the production of different active compounds from fruit by-products, and their therapeutic properties. The potential use of fruits by-products in different industries will be also discussed.

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Avocado seeds (Persea americana Mill.) prevents indomethacin-induced gastric ulcer in mice

Cited by 53 publications

References 39 publications

Fruit Seeds as Sources of Bioactive Compounds: Sustainable Production of High Value-Added Ingredients from By-Products within Circular Economy

Fruit Seeds as Sources of Bioactive Compounds: Sustainable Production of High Value-Added Ingredients from By-Products within Circular Economy

The Odyssey of Bioactive Compounds in Avocado (Persea americana) and Their Health Benefits

Fruits By-Products – A Source of Valuable Active Principles. A Short Review

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