Avocado roots treated with salicylic acid produce phenol-2,4-bis (1,1-dimethylethyl), a compound with antifungal activity

Rangel-Sánchez, Gerardo; Castro-Mercado, Elda; García-Pineda, Ernesto

doi:10.1016/j.jplph.2013.07.004

Cited by 61 publications

(30 citation statements)

References 54 publications

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“…First record of occurrence of Phenol, 2, 4, bis (1, 1, e dimethylethyl) e in ant venom was demonstrated by Nikbakhtzadeh et al (2009) and this study is the second one to indicate the presence of this compound in insects. The significance of this phenol compound in its role with antimicrobial potency was documented by Rangel-S anchez et al (2014). These ants lives in complex colonies and are very vulnerable to microbial attacks, thus they have various ways to prevent microbial pathogen within the colony (Cremer et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

Decahydroquinolines from the venom of a formicinae ant, Oecophylla smaragdina

Das

Dileepkumar

Krishnan

et al. 2014

Toxicon

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Section: Discussionmentioning

confidence: 99%

Decahydroquinolines from the venom of a formicinae ant, Oecophylla smaragdina

Das

Dileepkumar

Krishnan

et al. 2014

Toxicon

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“…Padmavathi et al (Padmavathi et al 2014) have previously reported the phenol, 2,4-bis (1,1-dimethylethyl) from seaweed associated bacterium to have inhibition to quorum sensing mediated biofilm formation in the uropathogen Serratia marcescens. Phenol 2,4-bis (1,1-dimethylethyl) has also been reported as the defense compound of avocado root which prevent the root rot caused by Phytophthora cinnamomi (Rangel-Sanchez et al 2014). Trans cinnamic acid produced by Photorhabdus luminescens, a nematode symbiont was also identified to be antagonistic to Fusicladium effusum, causal agent of Pecan scab (Bock et al 2014).…”

Section: Gc-ms Analysis Of Nocardiopsis Sp Zoa1 Extractmentioning

confidence: 99%

Endophytic Nocardiopsis sp. from Zingiber officinale with both antiphytopathogenic mechanisms and antibiofilm activity against clinical isolates

2017

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Novel and potential antimicrobial compounds are essential to tackle the frequently emerging multidrugresistant pathogens and also to develop environment friendly agricultural practices. In the current study, endophytic actinomycetes from rhizome of Zingiber officinale were explored in terms of its diversity and bioactive properties. Fourteen different organisms were isolated, identified and screened for activity against Pythium myriotylum and human clinical pathogens. Among these, Nocardiopsis sp. ZoA1 was found to have highest inhibition with excellent antibacterial effects compared to standard antibiotics. Remarkable antibiofilm property was also shown by the extract of ZoA1. Its antifungal activity against Pythium and other common phytopathogens was also found to be promising as confirmed by scanning electron microscopic analysis. By PCR-based sequence analysis of phz E gene, the organism was confirmed for the genetic basis of phenazine biosynthesis. Further GC-MS analysis of Nocardiopsis sp. revealed the presence of various compounds including Phenol, 2,4-bis (1,1-dimethylethyl) and trans cinnamic acid which can have significant role in the observed result. The current study is the first report on endophytic Nocardiopsis sp. from ginger with promising applications. In vivo treatment of Nocardiopsis sp. on ginger rhizome has revealed its inhibition towards the colonization of P. myriotylum which makes the study to have promises to manage the severe diseases in ginger like rhizome rot.

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“…8,9) The compound has been suggested to represent antioxidant, antibacterial, and antifungal activities. [10][11][12] To the best of our knowledge, there are no available reports on the effects of BP against TMT-induced cognitive impairment in the context of AChE inhibition. The aim of the present work was therefore to investigate the possible cognitive protection of BP against neurodegeneration induced by TMT.…”

Section: )mentioning

confidence: 99%

2,4-Bis(1,1-dimethylethyl)phenol from <i>Cinnamomum loureirii</i> Improves Cognitive Deficit, Cholinergic Dysfunction, and Oxidative Damage in TMT-Treated Mice

Kim

Choi

Kim

et al. 2017

Biological & Pharmaceutical Bulletin

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We previously reported that the extract of Cinnamomum loureirii (C. loureirii) significantly inhibited acetylcholinesterase (AChE), and identified 2,4-bis(1,1-dimethylethyl)phenol (BP) from C. loureirii as a potential AChE inhibitor. The present study, therefore was undertaken to demonstrate the effects of BP from C. loureirii on learning and memory impairment in trimethyltin (TMT)-treated ICR mice. Y-maze and passive avoidance tests were used to test cognitive ability. Further, changes in biochemical parameters in the brain tissue were also assessed in response to TMT injection and BP intervention. BP pre-administration (20, 40 mg/kg/d) in mice significantly protected cognitive dysfunction induced by TMT (p<0.05). Moreover, BP reduced AChE activity and lipid peroxidation but increased acetylcholine levels in the brain. In conclusion, we suggested that BP protected against TMT-induced cognitive dysfunction, and might be a potential agent for alleviating symptoms of neurodegenerative disorders, such as Alzheimer's disease, via modulating cholinergic functions.

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Avocado roots treated with salicylic acid produce phenol-2,4-bis (1,1-dimethylethyl), a compound with antifungal activity

Cited by 61 publications

References 54 publications

Decahydroquinolines from the venom of a formicinae ant, Oecophylla smaragdina

Decahydroquinolines from the venom of a formicinae ant, Oecophylla smaragdina

Endophytic Nocardiopsis sp. from Zingiber officinale with both antiphytopathogenic mechanisms and antibiofilm activity against clinical isolates

2,4-Bis(1,1-dimethylethyl)phenol from <i>Cinnamomum loureirii</i> Improves Cognitive Deficit, Cholinergic Dysfunction, and Oxidative Damage in TMT-Treated Mice

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