2020
DOI: 10.1038/s41598-020-62334-y
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Avocado-derived polyols for use as novel co-surfactants in low energy self-emulsifying microemulsions

Abstract: Avocado (Persea americana Mill.; Lauraceae) seed-derived polyhydroxylated fatty alcohols (PFAs) or polyols (i.e., avocadene and avocadyne) are metabolic modulators that selectively induce apoptosis of leukemia stem cells and reverse pathologies associated with diet-induced obesity. Delivery systems containing avocado polyols have not been described. Herein, natural surface active properties of these polyols are characterized and incorporated into self-emulsifying drug delivery systems (SEDDS) that rely on mole… Show more

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Cited by 19 publications
(13 citation statements)
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“…While previous studies (Lee et al, 2015) (Ahmed et al, 2020) (Tabe et al, 2018) AML is a devastating blood cancer with limited therapeutic options that fail to eliminate the entire cancer cell population and are toxic to the normal hematopoietic population (Löwenberg et al, 2011)(Khwaja et al, 2016. Compared to the normal hematopoietic population, AML populations exhibit a distinct mitochondrial phenotype characterized by an increased reliance on higher rates of FAO (Samudio et al, 2010) (German et al, 2016) with a diminished capacity to oxidize other substrates upon inhibition of oxidative metabolism (Molina et al, 2018) (Lagadinou et al, 2013) (Sharon et al, 2019).…”
Section: Discussionmentioning
confidence: 99%
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“…While previous studies (Lee et al, 2015) (Ahmed et al, 2020) (Tabe et al, 2018) AML is a devastating blood cancer with limited therapeutic options that fail to eliminate the entire cancer cell population and are toxic to the normal hematopoietic population (Löwenberg et al, 2011)(Khwaja et al, 2016. Compared to the normal hematopoietic population, AML populations exhibit a distinct mitochondrial phenotype characterized by an increased reliance on higher rates of FAO (Samudio et al, 2010) (German et al, 2016) with a diminished capacity to oxidize other substrates upon inhibition of oxidative metabolism (Molina et al, 2018) (Lagadinou et al, 2013) (Sharon et al, 2019).…”
Section: Discussionmentioning
confidence: 99%
“…Jackson Laboratory) mice were used for xenotransplant and engraftment studies and conducted as previously described (Lee et al, 2015). A oil-in-water emulsion containing AYNE was used for treating mice (Ahmed et al, 2020). In brief, 50 µL of NeoBeeM5 (Stepan) and 50 µL of Tween Tumor volumes were measured as previously described (Lee et al, 2015) and tumor burden was calculated relative to each mouse's weight.…”
Section: In Vivo Studiesmentioning
confidence: 99%
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