Avian reovirus: a furious and fast evolving pathogen

Egana-Labrin, Sofia; Broadbent, Andrew J.

doi:10.1099/jmm.0.001761

Cited by 2 publications

(3 citation statements)

References 26 publications

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“…The viral genome comprises 10 segments, which are distinguished by size through electrophoretic mobility. These segments are categorized into three classes: the L class (L1-L3), M class (M1-M3), and S class (S1-S4) [1,2]. Except for S1, which encodes three proteins (i.e., p10, p17, and σC), all segments are monocistronic [1].…”

Section: Introductionmentioning

confidence: 99%

“…Concurrently, the understanding of the genetic variability of ARV has expanded. The σC protein, which forms the homotrimer responsible for viral attachment, is also targeted by neutralizing antibodies [2,12]. Owing to its biological implications and greater variability compared to other genome regions, the S1 segment is commonly used for sequencing, phylogenetic analysis, and molecular epidemiology studies.…”

Section: Introductionmentioning

confidence: 99%

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Reconstruction of Avian Reovirus History and Dispersal Patterns: A Phylodynamic Study

Franzo,

Tucciarone,

Faustini

et al. 2024

Viruses

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Avian reovirus (ARV) infection can cause significant losses to the poultry industry. Disease control has traditionally been attempted mainly through vaccination. However, the increase in clinical outbreaks in the last decades demonstrated the poor effectiveness of current vaccination approaches. The present study reconstructs the evolution and molecular epidemiology of different ARV genotypes using a phylodynamic approach, benefiting from a collection of more than one thousand sigma C (σC) sequences sampled over time at a worldwide level. ARVs’ origin was estimated to occur several centuries ago, largely predating the first clinical reports. The origins of all genotypes were inferred at least one century ago, and their emergence and rise reflect the intensification of the poultry industry. The introduction of vaccinations had only limited and transitory effects on viral circulation and further expansion was observed, particularly after the 1990s, likely because of the limited immunity and the suboptimal and patchy vaccination application. In parallel, strong selective pressures acted with different strengths and directionalities among genotypes, leading to the emergence of new variants. While preventing the spread of new variants with different phenotypic features would be pivotal, a phylogeographic analysis revealed an intricate network of viral migrations occurring even over long distances and reflecting well-established socio-economic relationships.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Reconstruction of Avian Reovirus History and Dispersal Patterns: A Phylodynamic Study

Franzo,

Tucciarone,

Faustini

et al. 2024

Viruses

View full text Add to dashboard Cite

show abstract

“…ARV, a non-enveloped virus with a particle size from 70 to 80 nm, belongs to the Orthoreovirus genus of the Reoviridae family [ 39 , 40 , 41 ]. The genomes of ARV contain ten double-stranded RNA segments separated into three size classes, large (L1, L2, and L3), medium (M1, M2, and M3), and small (S1, S2, S3, and S4) according to their electrophoretic mobility, which encode twelve proteins, large (λA, λB, and λC), medium (μA, μB, and μC), and small (σC, P10, P17, σA, σB, and σNS) [ 42 , 43 , 44 , 45 ]. The σC is the most variable protein of ARV, which contains specific epitopes and is used as a genetic marker [ 46 , 47 , 48 , 49 ].…”

Section: Introductionmentioning

confidence: 99%

Molecular Detection and Genetic Characterization of Vertically Transmitted Viruses in Ducks

Wang,

Yu,

Zhang

et al. 2023

Animals

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To investigate the distribution and genetic variation in four vertically transmitted duck pathogens, including duck hepatitis B virus (DHBV), duck circovirus (DuCV), duck hepatitis A virus 3 (DHAV-3), and avian reoviruses (ARV), we conducted an epidemiology study using PCR and RT-PCR assays on a duck population. We found that DHBV was the most prevalent virus (69.74%), followed by DuCV (39.48%), and then ARV (19.92%) and DHAV-3 (8.49%). Among the 271 duck samples, two, three or four viruses were detected in the same samples, indicating that the coinfection of vertical transmission agents is common in ducks. The genetic analysis results showed that all four identified DuCV strains belonged to genotype 1, the DHAV-3 strain was closely clustered with previously identified strains from China, and the ARV stain was clustered under genotype 1. These indicate that different viral strains are circulating among the ducks. Our findings will improve the knowledge of the evolution of DuCV, DHAV-3, and ARV, and help choose suitable strains for vaccination.

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Avian reovirus: a furious and fast evolving pathogen

Cited by 2 publications

References 26 publications

Reconstruction of Avian Reovirus History and Dispersal Patterns: A Phylodynamic Study

Reconstruction of Avian Reovirus History and Dispersal Patterns: A Phylodynamic Study

Molecular Detection and Genetic Characterization of Vertically Transmitted Viruses in Ducks

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