Avian metapneumovirus subtype B vaccination in commercial broiler chicks: heterologous protection and selected host transcription responses to subtype A or B challenge

Ball, Christopher; Manswr, Basim; Herrmann, Andreas; Lemière, Stéphane; Ganapathy, Kannan

doi:10.1080/03079457.2022.2036697

Cited by 4 publications

(3 citation statements)

References 54 publications

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“…In recent years, however, detections of subtype A diminished significantly, at least in Europe, and subtype B consolidated its status as the predominant field threat [ 6 ]. It is also worth noting that most of the commercially available vaccines are based on subtype B and that heterologous cross-protection has been established for both chickens and turkeys [ 22 , 23 ], suggesting that the conclusions reached in the present study could be considered relevant in most of the epidemiological scenarios encountered around the world.…”

Section: Discussionmentioning

confidence: 73%

Vaccine Interaction and Protection against Virulent Avian Metapneumovirus (aMPV) Challenge after Combined Administration of Newcastle Disease and aMPV Live Vaccines to Day-Old Turkeys

et al. 2023

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Newcastle disease virus (NDV) and avian metapneumovirus (aMPV) are among the most impactful pathogens affecting the turkey industry. Since turkeys are routinely immunized against both diseases, the hatchery administration of the combined respective live vaccines would offer remarkable practical advantages. However, the compatibility of NDV and aMPV vaccines has not yet been experimentally demonstrated in this species. To address this issue, an aMPV subtype B live vaccine was administered to day-old poults either alone or in combination with one of two different ND vaccines. The birds were then challenged with a virulent aMPV subtype B strain, clinical signs were recorded and aMPV and NDV vaccine replication and humoral immune response were assessed. All results supported the absence of any interference hampering protection against aMPV, with no significant differences in terms of clinical scoring. In addition, the mean aMPV vaccine viral titers and antibody titers measured in the dual vaccinated groups were comparable or even higher than in the group vaccinated solely against aMPV. Lastly, based on the NDV viral and antibody titers, the combined aMPV and NDV vaccination does not seem to interfere with protection against NDV, although further studies involving an actual ND challenge will be necessary to fully demonstrate this hypothesis.

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Section: Discussionmentioning

confidence: 73%

Vaccine Interaction and Protection against Virulent Avian Metapneumovirus (aMPV) Challenge after Combined Administration of Newcastle Disease and aMPV Live Vaccines to Day-Old Turkeys

et al. 2023

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“…There are four (A-D) subtypes of aMPV documented, of which A and B subtypes show a worldwide distribution, whereas subtype C is reported mainly in the United States, France, South Korea, and China (43). The subtype D was only reported in France (45). Both live and inactivated subtype A and B vaccines are available globally, and cross-protection between the subtype A and B has been reported (46,47).…”

Section: Impact Of Live Viral Vaccines In the Control Of Major Poultr...mentioning

confidence: 99%

“…The subtype D was only reported in France (45). Both live and inactivated subtype A and B vaccines are available globally, and cross-protection between the subtype A and B has been reported (46,47).…”

Section: Impact Of Live Viral Vaccines In the Control Of Major Poultr...mentioning

confidence: 99%

Pros and Cons on Use of Live Viral Vaccines in Commercial Chicken Flocks

Ganapathy,

Parthiban

2023

Avian Diseases

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A novel live attenuated vaccine candidate protects against subtype B avian metapneumovirus in chickens

MENG,

YU,

WANG

et al. 2023

Journal of Integrative Agriculture

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Avian metapneumovirus subtype B vaccination in commercial broiler chicks: heterologous protection and selected host transcription responses to subtype A or B challenge

Cited by 4 publications

References 54 publications

Vaccine Interaction and Protection against Virulent Avian Metapneumovirus (aMPV) Challenge after Combined Administration of Newcastle Disease and aMPV Live Vaccines to Day-Old Turkeys

Vaccine Interaction and Protection against Virulent Avian Metapneumovirus (aMPV) Challenge after Combined Administration of Newcastle Disease and aMPV Live Vaccines to Day-Old Turkeys

Pros and Cons on Use of Live Viral Vaccines in Commercial Chicken Flocks

A novel live attenuated vaccine candidate protects against subtype B avian metapneumovirus in chickens

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