Avian leukosis virus subgroup J triggers caspase-1-mediated inflammatory response in chick livers

Liu, Xuelan; Shan, Wen-jie; Jia, Lijuan; Xu, Yu; Zhang, Jinjing; Wu, Yarong; Xu, Fazhi; Li, Jinnian

doi:10.1016/j.virusres.2016.01.011

Cited by 12 publications

(9 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The oncogenic retrovirus avian leukosis virus (ALV) causes a major infectious disease that leads to poor egg laying performance in chickens and impacts the poultry industry worldwide [16]. There are seven subgroups of ALV in chickens: ALV-A, -B, -C, -D, -E, -J and –K [17, 18].…”

Section: Introductionmentioning

confidence: 99%

Circular RNA alterations are involved in resistance to avian leukosis virus subgroup-J-induced tumor formation in chickens

et al. 2017

View full text Add to dashboard Cite

Avian leukosis virus subgroup (ALV-J) is an oncogenic neoplasm-inducing retrovirus that causes significant economic losses in the poultry industry. Recent studies have demonstrated circular RNAs (circRNAs) are implicated in pathogenic processes; however, no research has indicated circRNAs are involved in resistance to disease. In this study, over 1800 circRNAs were detected by circRNA sequencing of liver tissues from ALV-J-resistant (n = 3) and ALV-J-susceptible chickens (n = 3). 32 differentially expressed circRNAs were selected for analyzing including 12 upregulated in ALV-J-resistant chickens and 20 upregulated in ALV-J-susceptible chickens, besides, the top five microRNAs (miRNAs) for 12 upregulated circRNAs in ALV-J-resistant chickens were analyzed. Gene ontology and KEGG pathway analyses were performed for miRNA target genes, the predicted genes were mainly involved in immune pathways. This study provides the first evidence that circRNA alterations are involved in resistance to ALV-J-induced tumor formation. We propose circRNAs may help to mediate tumor induction and development in chickens.

show abstract

Section: Introductionmentioning

confidence: 99%

Circular RNA alterations are involved in resistance to avian leukosis virus subgroup-J-induced tumor formation in chickens

et al. 2017

View full text Add to dashboard Cite

show abstract

“…The LAT is a palmitoylated integral membrane adaptor protein that is phosphorylated by protein tyrosine kinases (PTK) and binds to the adaptors Gads, Grb2 and phospholipase Cγ1 (PLCγ1) to drive T-cell activation [63]. The CASP1 is a cysteine protease that acts as an essential regulator of inflammatory responses [64]. Innate immunity plays a role in both thrombosis and inflammation [65].…”

Section: Discussionmentioning

confidence: 99%

“…They play an immunomodulatory role by mediating surface expression and signaling of diverse B cell receptor complexes on precursor, immature, and mature B cells [81]. Innate immunity plays a role in both thrombosis and inflammation [64]. Dendritic cells (DC), the potent antigen-presenting cells, stimulate T-cell proliferation and activation to induce the growth of atherosclerotic plaques during adaptive immunity [82].…”

Section: The Ce-pin Of Tanshinonesmentioning

confidence: 99%

Mechanism of tanshinones and phenolic acids from Danshen in the treatment of coronary heart disease based on co-expression network

Huo

Chen

et al. 2020

BMC Complement Med Ther

View full text Add to dashboard Cite

Background: The tanshinones and phenolic acids in Salvia miltiorrhiza (also named Danshen) have been confirmed for the treatment of coronary heart disease (CHD), but the action mechanisms remain elusive. Methods: In the current study, the co-expression protein interaction network (Ce-PIN) was used to illustrate the differences between the tanshinones and phenolic acids of Danshen in the treatment of CHD. By integrating the gene expression profile data and protein-protein interactions (PPIs) data, the Ce-PINs of tanshinones and phenolic acids were constructed. Then, the Ce-PINs were analyzed by gene ontology enrichment analyzed based on the optimal algorithm. Results: It turned out that Danshen is able to treat CHD by regulating the blood circulation, immune response and lipid metabolism. However, phenolic acids may regulate the blood circulation by Extracellular calcium-sensing receptor (CaSR), Endothelin-1 receptor (EDNRA), Endothelin-1 receptor (EDNRB), Kininogen-1 (KNG1), tanshinones may regulate the blood circulation by Guanylate cyclase soluble subunit alpha-1 (GUCY1A3) and Guanylate cyclase soluble subunit beta-1 (GUCY1B3). In addition, both the phenolic acids and tanshinones may regulate the immune response or inflammation by T-cell surface glycoprotein CD4 (CD4), Receptor-type tyrosine-protein phosphatase C (PTPRC). Conclusion: Through the same targets of the same biological process and different targets of the same biological process, the tanshinones and phenolic acids synergistically treat coronary heart disease.

show abstract

Section: Immunity Against Alvmentioning

confidence: 99%

“…However, a caspase-1-mediated inflammatory response could be triggered by ALV-J infection in chick livers (30). Caspase-1 expression combined with adaptor NLRP3 enabled IL-1β and IL-18 increases at 5 or 7 dpi (30). NLRP3 is an important initiator protein of the inflammasome, a multicomponent complex that activates caspase-1 and results in IL-1β and IL-18 secretion (31).…”

Section: Immunity Against Alvmentioning

confidence: 99%

Immunity to Avian Leukosis Virus: Where Are We Now and What Should We Do?

Feng

Zhang

2016

Front. Immunol.

View full text Add to dashboard Cite

Avian leukosis virus (ALV) is an avian oncogenic retrovirus causing enormous economic losses in the global poultry industry. Although ALV-related research has lasted for more than a century, there are no vaccines to protect chickens from ALV infection. The interaction between chickens and ALV remains not fully understood especially with regard to the host immunity. The current review provides an overview of our current knowledge of innate and adaptive immunity induced by ALV infection. More importantly, we have pointed out the unknown area involved in ALV-related studies, which is worthy of our serious exploring in future.

show abstract

Avian leukosis virus subgroup J triggers caspase-1-mediated inflammatory response in chick livers

Cited by 12 publications

References 29 publications

Circular RNA alterations are involved in resistance to avian leukosis virus subgroup-J-induced tumor formation in chickens

Circular RNA alterations are involved in resistance to avian leukosis virus subgroup-J-induced tumor formation in chickens

Mechanism of tanshinones and phenolic acids from Danshen in the treatment of coronary heart disease based on co-expression network

Immunity to Avian Leukosis Virus: Where Are We Now and What Should We Do?

Contact Info

Product

Resources

About