Avian influenza virus infection induces differential expression of genes in chicken kidney

Zhang, Wanpo; Li, Huiying; Cheng, Guofu; Hu, Sishun; Li, Zili; Bi, Dingren

doi:10.1016/j.rvsc.2007.05.015

Cited by 18 publications

(15 citation statements)

References 28 publications

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“…CHAC1 induction may induce a biphasic signal, first for cell cycle arrest, allowing the cell time to adapt to the stress, followed by apoptosis if the stress is insurmountable. Future work should elucidate this pathway and may have importance in health and disease because CHAC1 has been implicated in atherosclerosis (30), cancer (38 -41), liver metabolism (42), viral infection (43,44), and retinal axonal damage (45).…”

Section: Discussionmentioning

confidence: 99%

Human CHAC1 Protein Degrades Glutathione, and mRNA Induction Is Regulated by the Transcription Factors ATF4 and ATF3 and a Bipartite ATF/CRE Regulatory Element

Crawford

Prescott

Sylvester

et al. 2015

Journal of Biological Chemistry

164

141

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Background: CHAC1 is associated with the stress response in atherosclerosis. Results: ATF4, ATF3, and CEBP␤ regulate CHAC1 transcription. Human CHAC1 protein overexpression depletes glutathione. Conclusion: CHAC1 is induced following multiple cell stress signals and leads to depletion of glutathione. Significance: CHAC1 may be an essential link between stress signaling and the oxidative status of the cell, contributing to multiple diseases.

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Section: Discussionmentioning

confidence: 99%

Human CHAC1 Protein Degrades Glutathione, and mRNA Induction Is Regulated by the Transcription Factors ATF4 and ATF3 and a Bipartite ATF/CRE Regulatory Element

Crawford

Prescott

Sylvester

et al. 2015

Journal of Biological Chemistry

164

141

View full text Add to dashboard Cite

show abstract

“…Subtracted clones were subjected to screening for the differential expression of the unique genes (Zhang et al, 2008). Individual PCR products were firstly denatured with 0.3 M NaOH, spotted onto nylon membranes (Hybond) in duplicate and fixed by baking in an oven at 808C for 2 h. DIG-labelled cDNA probes from either the forward or reverse subtractions were prepared, using the DIG High Prime DNA Labeling and Detection Starter Kit I (Roche Applied Science, Mannheim, Germany), according to the manufacturer's protocols.…”

Section: Methodsmentioning

confidence: 99%

Identification of differentially expressed genes in the growth plate of broiler chickens with thiram-induced tibial dyschondroplasia

Tian

Zhang

et al. 2009

Avian Pathology

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Tibial dyschondroplasia (TD) is characterized by expansion of the proximal growth plates of the tibiotarsus that fail to form bone, lack blood vessels, and contain non-viable cells. Thiram (a carbamate pesticide), when fed to young broiler chicks, induces TD with high regularity and precision. We used this experimental model to understand the cause of the defects associated with TD by selecting and identifying the genes differentially expressed in the TD growth plate of broiler chickens. Broiler chicks at 7 days of age were randomly divided into two groups. After fasting overnight, they were fed with regular diet (control) or the same diet containing 100 mg/kg thiram for 96 h to induce TD (thiram-fed). mRNA was purified from the growth plates of control and thiram-fed broilers. Forward and reverse-subtracted cDNA libraries were generated by suppression subtractive hybridization technology. Ten selected genes from cDNA libraries were identified by real-time quantitative polymerase chain reaction. All were differentially expressed in TD growth plates (PB0.05 or PB0.01). The levels of collagen type X (Col X), pro-alpha-1 collagen type I (Col I a1), collagen type IX (Col IX), NADH dehydrogenase (NADH DH), cytochrome C oxidase subunit III (COX III), enolase 1, alpha (ENO1), carbonic anhydrase II (CA2) and heat shock protein 90 (Hsp90) mRNA transcripts were upregulated, while the expression levels of Matrilin 3 (MATN3) and chondromodulin-I (ChM-I) were downregulated. Col I and Hsp90 were detected by immunohistochemistry at different stages. Given that these genes are involved in matrix formation, endochondral ossification, developmental regulation, electron transport in the mitochondrial respiratory chain and vascularization, our findings may provide new insights into understanding the pathogenesis of TD.

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“…With virus infection, glutathione S-transferase genes (GSTs) were found to be significantly up-regulated [37] . GSTs in insects have been considered to be responsible for detoxification and recovery of oxidative stress.…”

Section: Identification Of Host-derived Proteinsmentioning

confidence: 99%

Determination of Protein Composition and Host-Derived Proteins of <i>Bombyx mori</i> Nucleopolyhedrovirus by 2-Dimensional Electrophoresis and Mass Spectrometry

et al. 2008

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Objective: The occlusion-derived form of baculovirus is specially adapted for primary infection of host midgut epithelial cells. The virion contains proteins essential for host-range determination and initiation of infection. Determination of protein composition of the occlusion-derived virus (ODV) will help us to understand this virion’s infection mechanism. Methods: We obtained the ODV virion of Bombyx mori nucleopolyhedrovirus (BmNPV) by sucrose density gradient centrifugation, and used SDS-PAGE, 2-dimensional electrophoresis and mass spectrometry to identify – for the first time – proteins present within or associated with the ODV virion. Results: 20 proteins, including 16 major proteins of the virion encoded by BmNPV and 4 proteins of the silkworm, were identified with confidence. Conclusion: Three BmNPV proteins (orf40, P95 and protein tyrosine phosphatase), which had not been detected as components of ODV previously, were identified in this study. We propose that the host-derived proteins may be important for the assembly and maturation of the ODV capsid.

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Avian influenza virus infection induces differential expression of genes in chicken kidney

Cited by 18 publications

References 28 publications

Human CHAC1 Protein Degrades Glutathione, and mRNA Induction Is Regulated by the Transcription Factors ATF4 and ATF3 and a Bipartite ATF/CRE Regulatory Element

Human CHAC1 Protein Degrades Glutathione, and mRNA Induction Is Regulated by the Transcription Factors ATF4 and ATF3 and a Bipartite ATF/CRE Regulatory Element

Identification of differentially expressed genes in the growth plate of broiler chickens with thiram-induced tibial dyschondroplasia

Determination of Protein Composition and Host-Derived Proteins of <i>Bombyx mori</i> Nucleopolyhedrovirus by 2-Dimensional Electrophoresis and Mass Spectrometry

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