Avian Cerebellar Teratoma

Jones, Lloyd D.

doi:10.2307/1587946

Cited by 16 publications

(8 citation statements)

References 2 publications

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“…Most reported tumors are gonadal in origin and are seldom malignant [3,16, 171. Extragonadal teratomas are extremely rare in animals; they have been reported in the cranium of the horse, ox, guinea pig, chicken and rabbit [I-3, 8, 10,16, 221. Intracranial teratomas, both benign and malignant, are more common in man [4,5,7,9,13,15,[18][19][20].…”

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Intracranial Teratocarcinoma in a Dog

Patnaik¹,

Nafe²

1980

Vet Pathol

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Spontaneous teratomas are rare in domestic animals [3]. Most reported tumors are gonadal in origin and are seldom malignant [3,16, 171. Extragonadal teratomas are extremely rare in animals; they have been reported in the cranium of the horse, ox, guinea pig, chicken and rabbit [I-3, 8, 10,16, 221. Intracranial teratomas, both benign and malignant, are more common in man [4,5,7,9,13,15,[18][19][20]. In the dog, gonadal teratomas have been reported in the ovary but not in the testis [3, 16, 171; there are no reports of extragonadal teratomas in dogs.A 4-year-old male mixed-breed dog had lethargy, depression and anorexia for four days. Physical and neurologic examinations showed dilated pupils, poor response to light, oculocephalic reflex, poor movement of the left eye and bilateral ptosis of the third eyelid. A rostra1 midbrain lesion affecting the third to fifth cranial nerves was suspected. The dog became stuporous, depressed and semicomatose over the next two days. Cerebrospinal fluid analysis (3342 red blood cells/pl, 145 white blood cells/pl and total protein 45 mg/dl) and results of an electroencephalogram indicated an inflammatory process. Bacteriologic culture of the cerebrospinal fluid was negative and the results of a complete blood count were normal. The dog was killed at the owner's request.On necropsy, a 2.5 X 2.5 cm flattened irregular mass was found in the hypothalamic area.The mass was soft and brownish-gray, with minute cysts and large areas of hemorrhage and necrosis. It involved the optic chiasm and optic nerves anteriorly and the midportion of the pons posteriorly. The tumor extended toward the right, partially compressing the piriform lobe. The third and fourth cranial nerves were directly involved, and examination of coronal sections showed compression of the fourth to seventh cranial nerves. The neoplasm infiltrated without a clear margin into the region of the thalamus and the piriform lobes, more extensively on the right side, but it did not invade the ventricles. It also infiltrated the dura mater in the hypophyseal region ( fig. I). Histologic examination showed that the pituitary gland was compressed by the neoplasm, with parts of the gland adjoining the tumor infiltrated with neoplastic cells. The neoplasm was characterized by a complex mixture of various cell types and patterns ( fig. 2). Four cell types predominated. One group was composed of sheets of cells separated by a thin vascular stroma ( fig. 3). The cells were large to medium-size with hyperchromatic nuclei, some prominent nucleoli and pale, eosinophilic indistinct cytoplasm. Mitotic and giant cells were present. The second group was composed of aggregates of six or seven cells, separated by stroma. The cells had vacuolated cytoplasm and crescent nuclei, and the cytoplasm stained with oil red 0 for fat. There were occasional polygonal cells in this group with pale, eosinophilic cytoplasm and vesiculated nuclei (fig. 4).Between and within these groups of cells there were polygonal epithelial cells forming glandular structure...

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Intracranial Teratocarcinoma in a Dog

Patnaik¹,

Nafe²

1980

Vet Pathol

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“…The proliferating cell nuclear antigen immunoreactivity of most of the tissue components of the teratoma suggests that the tumour had the capacity for growth. Sugiyama et al (1983), Gupta (1976), Helmboldt et al (1974), Campbell & Appleby (1966), Feldman & Olson (1959), Jones (1964), Campbell (1951, 1962, Mashar (1932) Pekin duck (Anas platyrhynchos domestica), Muscovy duck (Cairina moschata); hybrids (11 cases)…”

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Extragonadal teratoma in a domestic turkey (Meleagris gallopavo domestica)

et al. 2012

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This is the first report of a primary, spontaneous and, most probably, congenital teratoma in a domestic turkey, localized in front of the left eyeball. The unique localization allowed surgical excision of the tumour. The histopathological examination revealed that the tumour included structures derived from all three germ cell layers: ectoderm, mesoderm and endoderm (e.g. cartilaginous, osseous, haematopoietic, fibrous, nervous, glandular, squamous epithelial and smooth muscle tissues). The presence of epithelial cells as well as smooth muscle cells was confirmed using anti-cytokeratin and anti-desmin antibodies, respectively. The proliferative activity of the tumour cells was confirmed using proliferating cell nuclear antigen immunostaining. The other cases of teratoma in wild and domestic birds are reviewed briefly.

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“…5,7 Teratomas and germcell tumors in general are mostly found in the gonads but sometimes occur in the neck or along the midline of the brain, generally involving the suprasellar, thalamic, or pineal regions. 3,5,9 In veterinary medicine, intracranial germ-cell tumors have been reported mostly in dogs 3,12,13,19 but also in the duck, 4 rat, 16 chicken, 8 horse, 10 and rabbit. 2 The affected animals were generally juveniles or young adults.…”

Section: Intracranial Teratoma and Dermoid Cyst In A Kittenmentioning

confidence: 99%