Avertoxins A–D, Prenyl Asteltoxin Derivatives from Aspergillus versicolor Y10, an Endophytic Fungus of Huperzia serrata

Abstract

Aspergillus versicolor Y10 is an endophytic fungus isolated from Huperzia serrata, which showed inhibitory activity against acetylcholinesterase. An investigation of the chemical constituents of Y10 led to the isolation of four new prenylated asteltoxin derivatives, named avertoxins A-D (2-5), together with the known mycotoxin asteltoxin (1). In the present study, we report structure elucidation for 2-5 and the revised NMR assignments for asteltoxin and demonstrated that avertoxin B (3) is an active inhibitor against human acetylcholinesterase with the IC50 value of 14.9 μM (huperzine A as the positive control had an IC50 of 0.6 μM). In addition, the cytotoxicity of asteltoxin (1) and avertoxins A-D (2-5) against MDA-MB-231, HCT116, and HeLa cell lines was evaluated.

Asteltoxins with Antiviral Activities from the Marine Sponge-Derived Fungus Aspergillus sp. SCSIO XWS02F40

“…In addition; compound 2 also exhibited inhibitory activity against H1N1 with IC 50 value of 3.5˘1.3 µM. Compounds 2 and 3 were published online on 30 November 2015 as new compounds after the date we submitted on 2 November 2015 [25].…”

Production of Gentisyl Alcohol from Phoma herbarum Endophytic in Curcuma longa L. and Its Antagonistic Activity Towards Leaf Spot Pathogen Colletotrichum gloeosporioides

“…Ye et al (2014) has reported A. versicolor from rhizome of Paris marmorata [43]. A. versicolor has also been isolated from Chinese medicinal plant Huperzia serrata [44].…”

Antimicrobial Sesquiterpenoid Derivatives and Monoterpenoids from the Deep-Sea Sediment-Derived Fungus Aspergillus versicolor SD-330

“…Aspergillus versicolor is a chemically brilliant fungal species with immense potential to produce a wide range of unique secondary metabolites including alkaloids [1,2,3], polyketides [4,5,6], and terpenoids [7]. Some of these metabolites exhibit intriguing biological properties, including antimicrobial properties [3,5] and cytotoxicity [6] as well as enzyme-inhibiting activities [1,4].…”

“…Some of these metabolites exhibit intriguing biological properties, including antimicrobial properties [3,5] and cytotoxicity [6] as well as enzyme-inhibiting activities [1,4]. …”