Aversive prenatal stimulation: Effects on behavioral, biochemical, and somatic ontogeny in the rat

Sobrian, Sonya K.

doi:10.1002/dev.420100107

Cited by 27 publications

(8 citation statements)

References 35 publications

(22 reference statements)

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“…Our results showed that the righting reflex of male and female neonates was altered by diet, inasmuch as fish oil retarded and coconut fat accelerated this reflex, and by stress, since PNS pups tended to exhibit longer time to right their bodies than their control counterparts. Some studies report a delayed maturation of the reflex and of the motor development of PNS animals (Meek et al, 2000; Patin et al, 2004), while others have not detected any effect of PNS (Secoli and Teixeira, 1998; Sobrian, 1977). The deleterious effect of stress may depend on the stage of development of the fetus, and would be stronger in the beginning of the ontogenesis of the central nervous system (Patin et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

Supplementation with fish oil and coconut fat prevents prenatal stress‐induced changes in early postnatal development

Borsonelo

Suchecki

Calil

et al. 2011

Intl J of Devlp Neuroscience

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Adequate development of the central nervous system depends on prenatal and postnatal factors. On one hand, prenatal stress (PNS) has been implicated in impaired development of the offspring. On other hand, nutritional factors during pregnancy and lactation can influence fetal and postnatal growth. This study assessed the postnatal development of rat offspring exposed to PNS, which consisted of restraint and bright lights, 3 times/day, from days 14 to 20 of pregnancy, whose mothers were fed different diets during pregnancy and lactation: regular diet, diet supplemented with coconut fat or fish oil. When pregnancy was confirmed, they were distributed into control (CTL) or PNS groups. At birth, PNS males and females weighed less than those in the group CTL. At 21 days of age, this alteration was no longer observed with fish oil and coconut fat groups. PNS and coconut fat diet induced increased locomotor activity in 13 day old male and female pups, and this effect was prevented by fish oil supplementation only in females. In conclusion, postnatal development from birth to weaning was influenced by PNS and diet and some of those alterations were prevented by coconut fat and fish oil.

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Section: Discussionmentioning

confidence: 99%

Supplementation with fish oil and coconut fat prevents prenatal stress‐induced changes in early postnatal development

Borsonelo

Suchecki

Calil

et al. 2011

Intl J of Devlp Neuroscience

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“…Other protocols used various stressors applied daily in repeated sequences (DeFries, Weir, & Hegmann, 1967;Pardon, Gerardin, Joubert, Perez-Diaz, & Cohen-Salmon, 2000). In each of these studies, the animals were subjected to stressors chronically, either during the entire pregnancy (Hockman, 1961;Fride & Weinstock, 1984;Rojo et al, 1985), the first (Suchecki & Palermo-Neto, 1991) or the second half of pregnancy (Herrenkohl & Whitney, 1976;Szuran, Zimmermann, & Welzl, 1994;Williams, Davis, McCrea, Long, & Hennessy, 1999), or at least during several consecutive days (Archer & Blackman, 1971;Fujioka et al, 1999;Sobrian, 1977).…”

Section: Effects Of Prenatal Stress: An Animal Modelmentioning

confidence: 99%

Effects of pre‐ and postnatal stimulation on developmental, emotional, and cognitive aspects in rodents: A review

Chapillon

Patin

Roy

et al. 2002

Developmental Psychobiology

181

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Interactions between the organism and its environment, during pregnancy as well as during the postnatal period, can lead to important neurobehavioral changes. We briefly review the literature, and successively present the main results from our laboratory concerning the behavioral effects of prenatal stress, differential rearing conditions, and postnatal handling. We show that submitting primiparous DA/HAN rats to an acute emotional stress (exposure to a cat) at gestational day10, 14, or 19 leads to greatly increased mortality of pups and to decreased body weight of surviving animals. The effects of such a stressor on emotional reactivity are less obvious. Cognitive processes are impaired depending on the learning task. Enriched environments restore abnormal behaviors (emotional reactivity, motor skills, motor and spatial learning) due to brain trauma or genetic deficiencies. In any case, environmental enrichment does prevent or slow down aging effects. The effects of postnatal handling noted when using classical tests of emotional reactivity also are clear when defensive reaction paradigms are used. Furthermore, pregnant females that are early handled are less anxious than nonhandled females. We hypothesize that, when subjected to a stressor, the offspring of early-handled females would be protected from the deleterious effects of this stress compared to pups of nonhandled females.

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“…Previous research involving prenatal manipulation and immune function in the offspring has focused on the effects of environmental toxins, dietary alterations and various pharmaceuticals (Silva et al 1968, Roberts & Chapman 1981, Schmidt 1984. Daily handling, anxiety, electric foot-shocks, restraint with or without bright lights and elevated temperatures, noise, crowding and other stressor stimuli applied to dams can cause these changes in their adult offspring (Ader & Plaut 1968, Fride & Weinstock 1984, 1989, Harvey & Chevins 1985, Sobrian 1988, VonSaal et al 1991, Sobrian et al 1992, Klein & Rager 1995, Silva & Palermo-Neto 1999, Williams et al 1999a. In contrast, power frequency alternating magnetic fields had no effect on reproduction and prenatal development of mice (Yasuyuki et al 2002).…”

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confidence: 99%

Role of TNF-α in prenatal alterations in dams of mice under thermal stress

et al. 2006

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The possible involvement of cytokines such as tumour necrosis factor-a (TNF-a), interleukin-1b (IL-1b) and interferon-g (IFN-g) that are suspected of causing pregnancy loss and miscarriage has been investigated in dams of mice subjected to hyperthermia. Thermal stress was induced by exposing mice dams at 40721C for 4 h every day during the different phases of the gestation period whereas the normothermic animals were housed at 22721C. The effect of maternal thermal stress was measured in pregnant mice at different phases of the gestation period namely, blastogenesis-implantation phase (days 0-5 postconceptionem [p.c.]), organogenesis or embryogenesis phase (days 6-15 p.c.) and fetogenesis phase (days 16-20 p.c.). Uterine examination of dams subjected to hyperthermia on days 6-15 p.c. showed maximum reduction in live fetus number, gestational index and maximum pre-and postimplantation loss in comparison with dams housed in normothermic environment and dams exposed to thermal stress between days 0-5 and 16-20 p.c. Maximum resorption rate and number of non-viable fetuses were observed in dams exposed to hyperthermia during days 6-15 p.c. Elevated levels of TNF-a and IL-1b were observed in the amniotic fluid of dams subjected to hyperthermia during days 6-15 p.c. but IFN-g levels remained unaltered. Single intraperitoneal (i.p.) administration of recombinant mouse TNF-a at a dose of 1 and 0.5 ng/ mice in dams on day 6 in normothermic condition resulted in a reduced number of live fetuses. Administration of anti-TNF-a antibody i.p. at a dose of 10 mg/dam on day 6 p.c. and subjected to thermal stress between days 6-15 p.c. increased marginally the number of fetuses but failed to attain statistical significance in comparison with days 6-15 p.c. thermally stressed dams without antibody treatment. It is concluded that the induction of TNF-a, in the amniotic fluid is associated with thermal stress during pregnancy and may be linked to the reproductive performances of dams. This study will help in understanding the mechanism of thermal injury in pregnant subjects.

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Aversive prenatal stimulation: Effects on behavioral, biochemical, and somatic ontogeny in the rat

Cited by 27 publications

References 35 publications

Supplementation with fish oil and coconut fat prevents prenatal stress‐induced changes in early postnatal development

Supplementation with fish oil and coconut fat prevents prenatal stress‐induced changes in early postnatal development

Effects of pre‐ and postnatal stimulation on developmental, emotional, and cognitive aspects in rodents: A review

Role of TNF-α in prenatal alterations in dams of mice under thermal stress

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