Avenanthramide-C Shows Potential to Alleviate Gingival Inflammation and Alveolar Bone Loss in Experimental Periodontitis

Kim, Su-Jin; Lee, Se Hui; Quang, Binh Do; Tran, Thanh-Tam; Kim, Young-Gwon; Ko, Jun; Choi, Weon-Young; Lee, Sun Young; Ryu, Je-Hwang

doi:10.14348/molcells.2023.0109

Cited by 3 publications

(1 citation statement)

References 40 publications

(53 reference statements)

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“…However, studies in the literature have already suggested that the daily optimal consumption of fruits and vegetables high in polyphenol compounds decreases the risk of developing specific chronic and degenerative diseases with an inflammatory component, via MMPs regulation [ 62 , 63 , 64 ]. Accordingly, multiple studies have examined the chemical composition of the raspberry leaf extract, uncovering a wide range of bioactive compounds that have prompted research into its potential uses in several diseases, especially those related to inflammation and metabolic disorders [ 22 , 65 ].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Rubus idaeus Polyphenols Extract in Induced Endometriosis in Rats

Jianu,

Pop,

Gherman

et al. 2024

Molecules

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Endometriosis is a common gynecological condition with a complex physio-pathological background. This study aimed to assess the role of Rubus idaeus leaf extract (RiDE) as a potential therapeutic agent in reducing the size of the endometriotic lesions and modulate the plasma expression of MMP-2, MMP-9, and TGF-β1. The endometriotic lesions were induced in a rat model by the autologous transplant of endometrium. Thirty-six female rats, Wistar breed, with induced endometriosis, were divided into four groups and underwent treatment for 28 days. The CTRL group received 0.5 mL/day of the vehicle; the DG group received 1 mg/kg b.w./day dienogest; the RiDG group received 0.25 mL/kg b.w./day RiDE and the D+RiDG group received 1 mg/kg b.w./day dienogest and 0.25 mL/kg b.w./day RiDE, respectively. Rats’ weight, endometriotic lesion diameter and grade, and plasma levels of MMP-2, MMP-9, and TGF-β1 were assessed before and after treatment. The administration of RiDE in association with dienogest vs. dienogest determined a lower weight gain and a reduction in diameter of the endometriotic lesions. RiDE administration restored MMP2 and MMP9 plasma levels to initial conditions. Rubus idaeus extract may help in reducing dienogest-associated weight gain, lower the size of endometriotic lesions, and have anti-inflammatory effects through MMP2 and MMP9 reduction.

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Section: Discussionmentioning

confidence: 99%

The Effect of Rubus idaeus Polyphenols Extract in Induced Endometriosis in Rats

Jianu,

Pop,

Gherman

et al. 2024

Molecules

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HLH-30/TFEB mediates sexual dimorphism in immunity in Caenorhabditis elegans

Sohn,

Kwon,

Lee

et al. 2024

Autophagy

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Licochalcone A attenuates NMDA-induced neurotoxicity

Kim,

Kim

et al. 2024

Animal Cells and Systems

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This study investigates the effect of Licochalcone A (Lico-A), a flavonoid from licorice roots known for its anti-inflammatory, anti-cancer, and antioxidant properties, on NMDA-induced neurotoxicity in primary cultured rat hippocampal neurons. The study measured cell survival following NMDA and Lico-A exposure, revealing that Lico-A at a 2.5 μg/ml significantly improved cell viability, countering the detrimental effects of NMDA. The study also analyzed synaptic changes by examining both postsynaptic density 95 (PSD95) and synaptophysin-targeted imaging, showing that Lico-A treatment resulted in a significant increase in synaptic puncta, contrasting with the reduction observed under NMDA exposure. Furthermore, levels of phosphorylated mixed lineage kinase domain-like pseudokinase (P-MLKL) and phosphorylated receptor-interacting serine/threonine-protein kinase 3 (P-RIP3), key necroptosis regulators, were measured using Western blotting. The results showed an increase in P-MLKL and P-RIP3 in neurons exposed to NMDA, which was reduced following Lico-A treatment. The response of astrocyte and microglia was also evaluated by immunostaining for glial fibrillary acidic protein (GFAP), ionized calcium-binding adaptor molecule 1 (IBA-1) and tumor necrosis factor alpha (TNF-α). These markers exhibited heightened expression in the NMDA group, which was substantially reduced by Lico-A treatment. These findings suggest that Lico-A has neuroprotective effects against NMDA-induced neurotoxicity, potentially contributing to synaptic preservation, inhibition of neuronal necroptosis, and modulation of glial activation. Therefore, Lico-A shows promise as a neuroprotective agent for conditions associated with NMDA-related neurotoxicity.

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Avenanthramide-C Shows Potential to Alleviate Gingival Inflammation and Alveolar Bone Loss in Experimental Periodontitis

Cited by 3 publications

References 40 publications

The Effect of Rubus idaeus Polyphenols Extract in Induced Endometriosis in Rats

The Effect of Rubus idaeus Polyphenols Extract in Induced Endometriosis in Rats

HLH-30/TFEB mediates sexual dimorphism in immunity in Caenorhabditis elegans

Licochalcone A attenuates NMDA-induced neurotoxicity

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