Avances sobre la influencia del tejido adiposo en el adenocarcinoma de próstata

Fontana, Constanza López; Artola, M. Eugenia Maselli; Rodríguez, M. Cristina Vanrell; Mónaco, Nicolás A. Di Milta; Elizalde, Rafael Pérez; Laur, José Daniel López

doi:10.1016/s0210-4806(09)74137-3

Cited by 6 publications

(9 citation statements)

References 42 publications

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“…Spermatic cord tumors can be grouped, according to location, in the testicular tunica, epididymis or spermatic cord [2]. The most common neoplasms are benign (70%) and most of these are represented by lipomas [3].…”

Section: Discussionmentioning

confidence: 99%

“…Benign tumors usually show a homogeneous, hypoechoic, well-delimited image in US, malignant neoplasms in this region tend to appear as a solid, hyperechoic, vascularized, heterogeneous mass with necrotic areas and of variable size that tends to displace the testis. The preoperative diagnosis between paratesticular and testicular masses can be complex; in these cases simple examination should be verified by imaging studies such as CT scan or MRI [2]. Tests for tumor markers such as AFP and HCG are essential for differential diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…if capsular invasion into the cord tissues is evident). According to the Intergroup Rhabdomyosarcoma Study, rhabdomyosarcomas are also the only sarcomas in which unilateral retroperitoneal lymphadenectomy in stages II, III and IV is recommended [2]. RPLND is not accepted for liposarcoma owing to the low malignancy potential [27,28,29].…”

Section: Discussionmentioning

confidence: 99%

“…There are few therapeutic adjuvants to surgery [2]. CHT for liposarcomas (well-differentiated liposarcoma) has only proved to be beneficial in high-grade subtypes or metastatic disease.…”

Section: Discussionmentioning

confidence: 99%

“…A review by Schwartz et al in 1995 [30] reports the results of treatment in six cases of liposarcoma of the spermatic cord; the study shows that there is no or almost no response to RT and CHT (doxorubicin). Single-agent and combination CHT regimens have been used to treat malignant fibrous histiocytoma, but the results have not been satisfactory [2]. Rhabdomyosarcomas are the only SCS that have shown improvement in all stages with systemic CHT based on vincristine, dactinomycin and cyclophosphamide [2].…”

Section: Discussionmentioning

confidence: 99%

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Spermatic Cord Sarcoma: Our Experience and Review of the Literature

et al. 2012

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Introduction: Spermatic cord tumors represent 4% of scrotal tumors. The most common neoplasms are lipomas. Spermatic cord sarcomas (SCS) of the genitourinary tract account for 2% of all urological tumors. Herein we presented our experience in the treatment of these tumors and a review of the literature. Patients and Methods: A review of the literature was performed using the Medline database with no restriction on language and date of published papers. The literature search used the following terms: epidemiology, surgery, chemotherapy, radiotherapy and spermatic cord sarcomas. Four cases treated from December 2009 to May 2010 are described. Results: All patients were treated with radical orchiectomy. The final pathological report showed different types of sarcomas. Two of the patients were treated with adjuvant chemotherapy. 12 months after surgery, 2/4 patients were alive without signs of relapse. Conclusion: SCS are very rare tumors with a poor prognosis. SCS’s prognostic factors have been identified in grading, size, depth of invasion and surgical margin status. Age and performance status of the patient are however very important. Lymphatic and hematogenous dissemination is uncommon. Surgery is the most important treatment both in the first approach and in local relapse. The role of adjuvant chemotherapy and radiation therapy is still debated.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…There are few therapeutic adjuvants to surgery [2]. CHT for liposarcomas (well-differentiated liposarcoma) has only proved to be beneficial in high-grade subtypes or metastatic disease.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Spermatic Cord Sarcoma: Our Experience and Review of the Literature

et al. 2012

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Influence of obesity on tumour volume in patients with prostate cancer

et al. 2011

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What ' s known on the subject? and What does the study add? Obesity is associated with more aggressive prostate cancer.Prostate cancer tumour volume is affected by excess weight, after adjustment for all possible clinical and pathological confounders. OBJECTIVE• To investigate the association between body mass index and tumour volume at radical prostatectomy in a large European population. PATIENTS AND METHODS• Recent data support the hypothesis that the hormonal environment in overweight and obese men may alter androgendependent prostate growth. Body mass index (BMI) has been implicated in prostate cancer pathophysiology.• We analysed 1275 patients with prostate cancer who underwent radical prostatectomy at a single tertiary care institution. Mean tumour volume (TV) was evaluated according to BMI WHO categories (normal < 25 kg/m 2 vs overweight 25 -30 kg/m 2 vs obese 30 -35 kg/m 2 vs severely obese > 35 kg/m 2 ).• Univariable linear regression analyses targeted the association between BMI and TV at radical prostatectomy. Multivariable analyses were adjusted for age, prostatespecifi c antigen value, biopsy Gleason sum, clinical stage and prostate volume. RESULTS• Mean BMI was 26.3 kg/m 2 (median 26; range 16.7 -42.0). Mean TV was 5.6 mL (median 3.3; range 0.1 -61.2). The mean prostate-specifi c antigen value was 10.3 ng/dL (median 6.6; range 0.3 -327).• The mean TV was 5.0, 5.8, 6.3 and 9.2 mL in normal, overweight, obese and severely obese patients, respectively ( P = 0.03). TVs in men with a normal BMI were 84% smaller than in severely obese men (5.0 vs 9.2 mL).• On univariable analysis, BMI was correlated with TV at radical prostatectomy ( P < 0.001). On multivariable analysis, BMI reached the independent predictor status after adjustment for age, prostate-specifi c antigen value, biopsy Gleason score, clinical stage and prostate volume ( P = 0.03). CONCLUSION• We showed that BMI is independently associated with prostate cancer volume at radical prostatectomy. The present results confi rm that obesity may play a key role in prostate cancer pathophysiology. KEYWORDSprostate cancer , tumour volume , body mass index , obesity Study Type -Prognosis (individual cohort) Level of Evidence 2b

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Overweight and obesity: a review of their relationship to metabolic syndrome, cardiovascular disease, and cancer in South America

et al. 2013

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Socioeconomic and demographic transformations are occurring very rapidly in some areas of the world, especially in South America, and are accompanied by changes in lifestyle, dietary patterns, and the epidemiological profile of prevalent diseases. This review examines whether obesity and overweight are related to metabolic syndrome, cardiovascular disease, and cancer in South America. Research carried out in more than 6,000 cases and controls was evaluated, along with most of the available publications related to South America. In South America, obesity and risk factors for cardiovascular disease are related mainly to aging, ethnicity effects, and preventable risky lifestyle conditions. Most of the studies that found an association between cancer and obesity are from the Southern Cone, the geographic area most affected by this pathology. Overall, the prevalence of metabolic syndrome was highest in Chile, followed in decreasing order by Colombia, Peru, Argentina, and Ecuador, with differences noted between urban and rural areas or between urban and periurban areas. Obesity and cancer may be preventable, at least in part, by healthy behavior; hence, exercise, weight control, and healthy dietary habits are important to reduce the risk of these major chronic diseases.

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Avances sobre la influencia del tejido adiposo en el adenocarcinoma de próstata

Abstract: Obesity may promote the progression of established PC rather than being a risk factor for the development of this tumour. However, additional studies are needed to clarify the relationship between adipokines and PC before developing new preventive or treatment strategies for this tumor.

Cited by 6 publications

References 42 publications

Spermatic Cord Sarcoma: Our Experience and Review of the Literature

Spermatic Cord Sarcoma: Our Experience and Review of the Literature

Influence of obesity on tumour volume in patients with prostate cancer

Overweight and obesity: a review of their relationship to metabolic syndrome, cardiovascular disease, and cancer in South America

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