Avaliação dos indicadores nutricionais e da composição corporal em hepatopatas crônicos e a relação com a etiologia e gravidade da doença

Vulcano, Daniela Salate Biagioni

doi:10.5016/dt000608183

Cited by 3 publications

(3 citation statements)

References 91 publications

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“…A study performed in 2010 found inverse correlation between hemoglobin and hematocrit with cirrhosis severity assessed by the CTP score (41) . In the present study, a decrease in the serum levels or negative correlation with CTP and BCLC in the hematocrit and hemoglobin values in patients with CI and HCC was observed.…”

Section: Discussionmentioning

confidence: 99%

Biochemical Nutritional Profile of Liver Cirrhosis Patients With Hepatocellular Carcinoma

Port

Oliveira

Soldera

et al. 2014

Arq. Gastroenterol.

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-Context -Liver cirrhosis patients with hepatocellular carcinoma present nutritional alterations and metabolic disorders that negatively impact the prognosis. Objective -The objective is to identify alterations in the metabolism of macro and micronutrients among liver cirrhosis patients with and without hepatocellular carcinoma and their relation to the Child-Turcote-Pugh score and Barcelona Clinic Liver Cancer staging. Methods -Analytical transversal study, with 31 hepatocellular carcinoma patients and 48 liver cirrhosis patients. Laboratorial exams were carried out. The existence of an association between the biochemical parameters and the disease severity as well as the presence of hepatocellular carcinoma was assessed. Results -The metabolic-nutritional profile of liver cirrhosis patients caused by the hepatitis C virus and hepatocellular carcinoma showed alterations, specifically the lipid (total cholesterol, HDL and triglycerides), protein (albumin, creatinine and uric acid), iron (transferrin, iron and ferritin saturation), hematocrit and hemoglobin, zinc and B12 vitamin profiles. There is a relation between nutritional biochemical markers and the Child-Turcote-Pugh, as well as Barcelona Clinic Liver Cancer staging. Conclusion -Considering the existence of alterations in the metabolism of nutrients in liver cirrhosis patients with and without hepatocellular carcinoma, and also that conventional nutritional assessment methods present limitations for this population, the biochemical laboratorial exams are valid to complement the diagnosis of the nutritional state in a quick and practical manner.

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Section: Discussionmentioning

confidence: 99%

Biochemical Nutritional Profile of Liver Cirrhosis Patients With Hepatocellular Carcinoma

Port

Oliveira

Soldera

et al. 2014

Arq. Gastroenterol.

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“…One of the possible explanations is the prevalent divergence regarding the applied method. In a study by Vulcano et al, the major prevalence of malnutrition in a subgroup of alcoholic patients was shown only when arm muscle circumference (ArMC) and arm circumference (ArC) were evaluated (29) .…”

Section: Discussionmentioning

confidence: 99%

Malnutrition in Cirrhosis: Association With Etiology and Hepatocellular Dysfunction

Oliveira

Fernandes

et al. 2020

Arq. Gastroenterol.

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BACKGROUND: The protein-energy malnutrition alters the prognosis of patients with cirrhosis. Its prevalence may vary according to the etiology of liver disease, it´s severity and the evaluation of the method applied. The infection by the hepatitis C virus (HCV) and alcoholism are the main etiologies of cirrhosis and result in a significant morbidity and mortality. OBJECTIVE: To evaluate the nutritional status of patients with cirrhosis according the liver disease etiology and severity. METHODS: It is a prospective study, in which the sample was for convenience and consisted of patients with cirrhosis, infected by HCV or alcoholic etiology. The nutritional status evaluation was carried out through anthropometry, food consumption, bioelectrical impedance (BIA) and subjective global assessment (SGA). The anthropometric data evaluated were weight, height, body mass index (BMI), triceps skinfold (TSF), circumference of the arm (CA), non-dominant handshake strength (FAM) and the adductor pollicis muscle thickness (APM). Patients were classified according to the severity of liver disease, using the Child-Pugh and Model for End-stage Liver Diseases (MELD) scores. RESULTS: Ninety patients with cirrhosis were evaluated, 47 with HCV and 43 with alcoholic etiology. The prevalence of protein-calorie malnutrition ranged from 10.9% to 54.3% in the HCV group and from 4.7% to 20.9% in the alcoholic group, depending on the method used for evaluation. The group with HCV infection presented a higher malnutrition prevalence in comparison to the alcoholic in the following evaluations: TSF (P<0.001), phase angle (PA) (P=0.016) and SGA (P=0.010). PA values were lower in patients with viral cirrhosis (5.68±1.05) when compared to those with alcoholic etiology (6.61±2.31) (P=0.016). When all patients were analyzed, regardless of etiology, an inversely correlation was observed among Child-Pugh score and PA values (P=0.018). CONCLUSION: HCV cirrhosis showed worse nutritional parameters in comparison to alcoholic etiology; however, the PA was associated with worse liver function in both etiologies.

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“…Com o aumento da concentração de chumbo no organismo interfere nas células tronco hematopoiéticas, diminuindo a síntese de hemoglobina, aumentando a destruição de células vermelhas, promovendo disfunção nas células brancas e redução e disfunção nas plaquetas. (CARVALHO, 2006), (CRUZ, 2012). Os dados desta pesquisa evidenciaram uma redução significativa na contagem de plaquetas no grupo ambientalmente exposto.…”

Section: Discussionunclassified

Avaliação da concentração sérica de chumbo e sua relação com marcadores bioquímicos e hematológicos em população ambientalmente exposta à agrotóxicos

Bressiani,

Chielle,

Vidigal

et al. 2023

Arch. Health

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Introdução: O chumbo é um metal pesado encontrado na composição de diferentes tipos de agrotóxicos os quais são amplamente utilizados por produtores rurais no controle de pragas. Os agrotóxicos são facilmente disseminados pelo ar, solo, água ou alimentos contaminados, possuem alto poder de intoxicação e podem causar diversas alterações no organismo como distúrbios gastrointestinais, neurológicos e até a morte. O objetivo deste estudo foi avaliar a concentração sérica de chumbo em população ambientalmente expostos à agrotóxicos, bem como parâmetros bioquímicos e hematológicos. Métodos: Tratou-se de um estudo transversal, com análise quantitativa em população organizada em dois grupos, participantes ambientalmente expostos à agrotóxicos (N= 23) e participantes não expostos (N= 21). Destes grupos foram coletadas amostras de sangue total e soro para a determinação de níveis séricos de chumbo, marcadores bioquímicos e parâmetros hematológicos. Resultados: Foi observado um aumento significativo na concentração sérica de chumbo (p=0,002), PCR-us (p=0,01), ureia (p=0,02) e na atividade da GGT (p=0,006), assim como uma redução significativa na contagem de plaquetas (p=0,01) nos voluntários ambientalmente expostos à agrotóxicos quando comparados com o grupo não exposto. Conclusão: Este estudo sugere que a população ambientalmente exposta à agrotóxico, pode apresentar aumento da concentração sérica de chumbo. Em longo prazo o acúmulo deste metal no organismo pode ser altamente tóxico, induzindo alterações bioquímicas e hematológicas e afetando severamente funções orgânicas.

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Avaliação dos indicadores nutricionais e da composição corporal em hepatopatas crônicos e a relação com a etiologia e gravidade da doença

Cited by 3 publications

References 91 publications

Biochemical Nutritional Profile of Liver Cirrhosis Patients With Hepatocellular Carcinoma

Biochemical Nutritional Profile of Liver Cirrhosis Patients With Hepatocellular Carcinoma

Malnutrition in Cirrhosis: Association With Etiology and Hepatocellular Dysfunction

Avaliação da concentração sérica de chumbo e sua relação com marcadores bioquímicos e hematológicos em população ambientalmente exposta à agrotóxicos

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