Avaliação dos efeitos colaterais da nevirapina em gestantes HIV positivo em Hospital Universitário do sul do Brasil

Kondo, William; Astori, Adriane de Assis Fischer de; Gomes, Suria El-Kouba; Fernandes, Rachelle de Brito; Sasaki, Maria das Graças; Sbalqueiro, Renato Luiz

doi:10.1590/s0100-72032008000100004

Cited by 6 publications

(2 citation statements)

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“…No patient suffered from both skin rash and liver abnormality in other studies [8, 11, 44, 47]. Hepatic involvement in HSR can also be observed without concomitant cutaneous reactions [44, 47].…”

Section: Hypersensitivity Syndrome Reactionmentioning

confidence: 85%

HIV-Antiretroviral Therapy Induced Liver, Gastrointestinal, and Pancreatic Injury

Neuman

Schneider

Nanau

et al. 2012

International Journal of Hepatology

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The present paper describes possible connections between antiretroviral therapies (ARTs) used to treat human immunodeficiency virus (HIV) infection and adverse drug reactions (ADRs) encountered predominantly in the liver, including hypersensitivity syndrome reactions, as well as throughout the gastrointestinal system, including the pancreas. Highly active antiretroviral therapy (HAART) has a positive influence on the quality of life and longevity in HIV patients, substantially reducing morbidity and mortality in this population. However, HAART produces a spectrum of ADRs. Alcohol consumption can interact with HAART as well as other pharmaceutical agents used for the prevention of opportunistic infections such as pneumonia and tuberculosis. Other coinfections that occur in HIV, such as hepatitis viruses B or C, cytomegalovirus, or herpes simplex virus, further complicate the etiology of HAART-induced ADRs. The aspect of liver pathology including liver structure and function has received little attention and deserves further evaluation. The materials used provide a data-supported approach. They are based on systematic review and analysis of recently published world literature (MedLine search) and the experience of the authors in the specified topic. We conclude that therapeutic and drug monitoring of ART, using laboratory identification of phenotypic susceptibilities, drug interactions with other medications, drug interactions with herbal medicines, and alcohol intake might enable a safer use of this medication.

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Section: Hypersensitivity Syndrome Reactionmentioning

confidence: 85%

HIV-Antiretroviral Therapy Induced Liver, Gastrointestinal, and Pancreatic Injury

Neuman

Schneider

Nanau

et al. 2012

International Journal of Hepatology

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“…Therefore, the frequency of DILI related to certain drugs may change regionally according to the characteristics of the populations studied and the profile of drug use. Some authors have studied specific populations taking tuberculostatic drugs, such as Brazilian native Americans[ 24 ], children[ 43 ], hepatitis B[ 44 ], hepatitis C[ 45 ], solid organ transplanted patients[ 46 ], smokers[ 41 ], HCV/HIV coinfected[ 47 ], and antiretroviral (ARV) in children and adolescents[ 48 ] and nevirapine in pregnant women[ 49 ].…”

Section: Discussionmentioning

confidence: 99%

Overview of drug induced liver injury in Brazil: What is the role of public health policy on the evidence?

Becker¹,

Schwambach²,

Lunardelli³

et al. 2021

WJGPT

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BACKGROUND Adverse drug reactions are responsible for increased costs and morbidity in the health system. Hepatotoxicity can be induced both by non-prescription drugs and by those used for chronic diseases. It is the main cause of safety-related drug marketing withdrawals and could be responsible for irreversible and fatal injuries. AIM To identify and to summarize Brazilian studies reporting the drug-induced liver injury. METHODS A systematic review of Brazilian studies was carried out until June 2020. It was found 32 studies, being 10 retrospective cohorts, 12 prospective cohorts, 5 cross-sectional, 3 case-control, one case series and one randomized clinical trial. In most studies were investigated tuberculosis patients followed by other infectious conditions like human immunodeficiency virus (HIV) and hepatitis C virus. The hepatotoxicity ranged from one to 57%, led by isoniazid, rifampicin, and pyrazinamide. Few studies reported algorithm to assess causality. In most studies, there were moderate outcomes and it was necessary drug interruption. However, few severe outcomes, such as chronic liver damage and liver transplantation were reported. RESULTS Twenty-two different criteria for hepatotoxicity were found. The great heterogeneity did not allow a meta-analysis. Standardization of parameter of drug-induced liver injury and greater effort in pharmacovigilance could contribute to learn more about drug-induced liver injury (DILI)’s epidemiology in Brazil. CONCLUSION The development of strategic public health policies seems to have an influence on the DILI scientific evidence in Brazil due to main studies are in HIV and tuberculosis line care, two strategic health policies in Brazil.

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Nevirapine-Associated Toxicity in Clinical Practice in Buenos Aires, Argentina

Bottaro

Huberman²,

Iannella³

et al. 2010

Journal of the International Association of Physicians in AIDS

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Objectives: To determine the incidence and risk factors for nevirapine (NVP)-associated toxicity in a cohort of HIV-infected people in Buenos Aires, Argentina. Design: Retrospective study. Methods: HIV-infected adults who received NVP-based highly active antiretroviral therapy (HAART) at least for 2 weeks between May 1997 and March 2008 were included in this study. We analyzed patients' age, gender, HIV transmission route, HIV disease stage, pregnancy, alcohol intake, adverse events, coinfection with hepatitis B or C virus, time until toxicity, and withdrawal rates. Results: A total of 1110 patients (631 men) were included. Rash was the most frequently observed adverse event; it was more frequent in women. The incidence of severe rash and hepatotoxicity was similar in women and men. Female sex was the only variable significantly associated with mild-to-moderate rash. High CD4 count, pregnancy, and chronic hepatitis were not associated with NVP-related toxicity. An undetectable viral load at the time of starting NVPtreatment resulted in a lower risk of NVP-related rash.

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Avaliação dos efeitos colaterais da nevirapina em gestantes HIV positivo em Hospital Universitário do sul do Brasil

Cited by 6 publications

References 0 publications

HIV-Antiretroviral Therapy Induced Liver, Gastrointestinal, and Pancreatic Injury

HIV-Antiretroviral Therapy Induced Liver, Gastrointestinal, and Pancreatic Injury

Overview of drug induced liver injury in Brazil: What is the role of public health policy on the evidence?

Nevirapine-Associated Toxicity in Clinical Practice in Buenos Aires, Argentina

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