Avaliação dos efeitos centrais dos florais de Bach em camundongos através de modelos farmacológicos específicos

Abstract

RESUMO: Os Remédios Florais de Bach (RFB), constituem um método alternativo de tratamento usado largamente na terapêutica de várias patologias em muitos países do mundo. Os RFB são reconhecidos como tratamento natural pela OMS desde 1956. Embora o mecanismo de ação dos RFB ainda não tenha sido elucidado, eles vêm sendo indicados para o tratamento de várias doenças neuropsiquiátricas. O objetivo do presente trabalho foi detectar possíveis efeitos centrais dos RFB em modelos farmacológicos utilizados na pesquisa de substâncias com efeitos ansiolíticos, hipnóticos, antidepressivos e neurolépticos. Para tanto, camundongos receberam um tratamento agudo via oral (0,45 mL) 1 hora antes dos testes. Os resultados mostraram que os fl orais Gorse e, em conjunto, White chestnut, Agrymony e Vervain exibiram perfi s antidepressivo e hipnótico, respectivamente. No modelo de ansiedade foi detectado efeito ansiolítico do fl oral Agrymony. Entretanto, não foram observados efeitos neurolépticos do fl oral Clematis. Os resultados nos levam a sugerir que os efeitos centrais dos fl orais avaliados podem ser parcialmente detectados através de modelos farmacológicos utilizados na pesquisa de agentes psicotrópicos. Unitermos: Remédios Florais de Bach (RFB), modelos farmacológicos, depressão, ansiedade, esquizofrenia, insônia. ABSTRACT: "Evaluation of central effects of Bach Flowers Remedies in mice using specifi c pharmacological models". The Bach Flowers Remedies (BFR's) are worldwide used as an alternative therapeutical approach for several pathologies, being considered by WHO as natural therapy since 1956. Despite the unknown mechanism of action, the BFR's have been widely used on treatment of several neuropsychiatry diseases. Based on pharmacological models used to detect ansiolitic, antidepressant, hypnotic and neuroleptyc effects of different substances, the aim of this work was to evaluate possible central effects of the BFR's. For this purpose, albino mice received BFR's treatment (0.45 mL) by oral route 1 hour prior to each test. The results revealed that the Gorse fl ower alone and a mix of White chestnut, Agrymony and Vervain showed antidepressant and hypnotic effects, respectively. On the anxiety model, Agrymony showed an ansiolitic effect but no neuroleptyc effects were observed for Clematis fl oral therapy. The herein described results allow us to conclude that the studied BFR's central effects may be partially detected through pharmacological models currently and widely used on psychotropic agents research.

Behavioral effects of essential oil of Citrus aurantium L. inhalation in rats

“…Popularly, they are used in the control of emotions and mood, for their sedative, anxiolytic (Lehrner et al, 2000), antidepressant effects (Komori et al, 1995a;De-Souza et al, 2006), and anticonvulsant (Viana et al, 2000;Sousa et al, 2007) among others (Oliveira et al, 2006;Ferronatto et al, 2007;Oliveira et al, 2007;Barbosa-Filho et al, 2008;Sousa et al, 2008). Some studies suggest that they act by modulating the central neurotransmission (Komiya et al, 2006).…”

Medicinal Plants and Herbal Medicines for Oral Health Promotion: Analysis of Students and Professionals Knowledge

“…A similar percentage of affirmation of the interviewees when questioned about the use of medicinal or phytotherapeutic plants by the client in the pre and postoperative period, 5.5% mentioned once again the malva (Malva sylvestris) and soon after 2.7% mentioned the arnica (Lychnophora ericoides). It was also mentioned the use of bach floral, not being classified as a herbal remedy, because it is a form of treatment that uses the energy of wildflowers to combat the negative emotions that cause diseases [23]. Still according to Armstrong; Ernst [24] bach florals as well as homoeopathic medicines, exert their action through the "energy" that is transmitted from the flowers to the medicine.…”

Florais de Bach para o Tratamento da Ansiedade/ Bach Flower Essences for the Treatment of Anxiety

“…Muitos céticos e médicos acreditam que os florais de bach são apenas placebo, em virtude de não possui princípio ativos dos extratos vegetais, os pesquisadores dos sistemas florais se distanciaram do princípio da acessibilidade do Dr. Bach. (SOUZA, 2006).…”