Avaliação do processo de dispensação de medicamentos aos portadores de hepatite C crônica em farmácias de componentes especializados da Secretaria de Estado da Saúde de São Paulo, em 2010

Venâncio, Sônia Isoyama; Bersusa, Ana Aparecida Sanches; Martins, Patrícia Nieri; Figueiredo, Gerusa Maria; Awakamatsu, Alda; Alves, Venâncio Avancini Ferreira

doi:10.5123/s1679-49742014000400012

Cited by 4 publications

(2 citation statements)

References 17 publications

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“…Approximately 3% of the world's population (170 million people) is afflicted with chronic HCV infections, which pose a risk for the development of cirrhosis, hepatocellular carcinoma, and liver failure [ 29 – 31 ].…”

Section: Discussionmentioning

confidence: 99%

Actinobacteria from Termite Mounds Show Antiviral Activity against Bovine Viral Diarrhea Virus, a Surrogate Model for Hepatitis C Virus

Padilla

Rodrigues

Bastos

et al. 2015

Evidence-Based Complementary and Alternative Medicine

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Extracts from termite-associated bacteria were evaluated for in vitro antiviral activity against bovine viral diarrhea virus (BVDV). Two bacterial strains were identified as active, with percentages of inhibition (IP) equal to 98%. Both strains were subjected to functional analysis via the addition of virus and extract at different time points in cell culture; the results showed that they were effective as posttreatments. Moreover, we performed MTT colorimetric assays to identify the CC50, IC50, and SI values of these strains, and strain CDPA27 was considered the most promising. In parallel, the isolates were identified as Streptomyces through 16S rRNA gene sequencing analysis. Specifically, CDPA27 was identified as S. chartreusis. The CDPA27 extract was fractionated on a C18-E SPE cartridge, and the fractions were reevaluated. A 100% methanol fraction was identified to contain the compound(s) responsible for antiviral activity, which had an SI of 262.41. GC-MS analysis showed that this activity was likely associated with the compound(s) that had a peak retention time of 5 min. Taken together, the results of the present study provide new information for antiviral research using natural sources, demonstrate the antiviral potential of Streptomyces chartreusis compounds isolated from termite mounds against BVDV, and lay the foundation for further studies on the treatment of HCV infection.

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Section: Discussionmentioning

confidence: 99%

Actinobacteria from Termite Mounds Show Antiviral Activity against Bovine Viral Diarrhea Virus, a Surrogate Model for Hepatitis C Virus

Padilla

Rodrigues

Bastos

et al. 2015

Evidence-Based Complementary and Alternative Medicine

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show abstract

“…Tal dado pode ser um indicativo de que há lacuna no procedimento administrativo para dispensação de medicamentos, o que pode se dar por falha no fluxo ou até mesmo por fator humano. Nesse sentido, um trabalho que avaliou a dispensação de medicamentos para hepatite C em quatro farmácias de componentes especializados da Secretaria de Saúde de São Paulo identificou que os exames clínicos solicitados para análise do caso variavam de farmácia para farmácia, havendo também aquela que fazia a dispensação baseada somente na prescrição médica 31 , o que indica que o sistema não está isento de equívocos.…”

Section: Os Dados Coletados Indicam Também Que Os Medicamentos Consta...unclassified

Judicialização de medicamentos para tratamento da hepatite C no estado do Rio Grande do Sul, Brasil

Vinholes,

Hirdes,

Botton

2023

SaudPesq

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O artigo tem por objetivo identificar quais motivos levaram as pessoas a buscarem o Poder Judiciário, a fim de obter medicamentos para tratamento da hepatite C. Trata-se de um estudo descritivo transversal, de natureza quantitativa, no qual foram analisados 235 acórdãos e decisões monocráticas proferidas pelo Tribunal de Justiça do Estado do Rio Grande do Sul entre os anos de 2010 e 2020. Os resultados evidenciam que o principal motivo pelo qual as pessoas recorrem ao Judiciário para tratamento da hepatite C é a insuficiência de renda, seguido pelo não atendimento aos requisitos do Protocolo Clínico e Diretrizes Terapêuticas para Hepatite C e Coinfecções, a ausência de previsão em lista pública de medicamentos, o estoque zerado e medicamento requerido sem registro na ANVISA. Os resultados também apontaram que a judicialização da saúde não é um fenômeno adstrito às pessoas de baixa renda; os medicamentos mais requeridos são a Ribavirina, o Interferon, o Sofosbuvir e o Daclatasvir; o percentual de concessão judicial de medicamentos é de 93,6%. Conclui-se que há necessidade de reavaliação do Protocolo Clínico e Diretrizes Terapêuticas para Hepatite C e Coinfecções, do Plano Nacional de Hepatites Virais e do Plano para Eliminação da Hepatite C.

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Immunohistochemical Assessment of Lymphatic Vessels in Human Livers With Chronic Hepatitis C - Relation to Histological Variables

Assato

Pasinato

Cirqueira

et al. 2022

Arq. Gastroenterol.

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Background Viral hepatitis C is a significant public health challenge. The disease may remain clinically silent in both acute and chronic forms, and chronic infections may progress to advanced disease such as cirrhosis and hepatocellular carcinoma, requiring costly treatment, compromising the patient’s quality of life and even leading to death. For this reason, it is one of the most frequent indications for liver transplantation. Although treatment with direct-acting antivirals represents remarkable progress, many patients are still infected and even those who cleared the viral infection must be followed due to their previous hepatic lesions, especially regarding the disturbances of lobular architecture and the sanguineal and lymphatic vessels. Objective To assess immunohistochemical aspects of lymphatic sprouts and mature lymphatic vascularity with histological variables of liver injury attributable to hepatitis C virus (HCV) and fatty disease. Methods The present study included 72 liver biopsies of cases with chronic hepatitis C. Morphologic changes reflecting “staging” and “activity” were analyzed. Immunohistochemical reactions were performed with monoclonal antibody D2-40 anti-podoplanin. Major histological variables were also semiquantified so as to enable the search for possible associations among histological and Immunohistochemical criteria, as well as with genotypes 1 and 3 of HCV. Results Histological findings showed that the different degrees of strutural changes were well represented in this casuistic. Intralobular/parenchymal necro-inflammatory activity was predominantly mild to moderate. Most cases did not show major evidences of fatty disease, which was found significantly higher in cases infected with HCV genotype 3. The amount of portal lymphatic sprouts increased along with the progression of structural changes, maximal at cirrhosis. Portal lymphatic sprouts as well as portal mature lymphatic vessels also showed an increase parallel to the increase in the degree of portal/septal inflammatory infiltrate. In the present study, no significant association was found between the proportion of portal lymphatic sprouts or portal mature lymphatic vessels and the degree of periportal/periseptal activity. No significant relations were detected between lymphatic sprouts/mature vessels and periportal or parenchymal inflammatory activity, nor with infections due to HCV genotype 1 or 3. Conclusion Visualization and semiquantitation of sprouts and mature lymphatic vessels were clearly yielded by Immunohistochemical staining with monoclonal antibody D2-40. The amount of lymphatics was increased along fibrogenic process, significantly related to progression of liver disease and maximal at cirrhosis. No significant relations were detected with necro-inflammatory activity at interface or in the parenchyma.

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Avaliação do processo de dispensação de medicamentos aos portadores de hepatite C crônica em farmácias de componentes especializados da Secretaria de Estado da Saúde de São Paulo, em 2010

Cited by 4 publications

References 17 publications

Actinobacteria from Termite Mounds Show Antiviral Activity against Bovine Viral Diarrhea Virus, a Surrogate Model for Hepatitis C Virus

Actinobacteria from Termite Mounds Show Antiviral Activity against Bovine Viral Diarrhea Virus, a Surrogate Model for Hepatitis C Virus

Judicialização de medicamentos para tratamento da hepatite C no estado do Rio Grande do Sul, Brasil

Immunohistochemical Assessment of Lymphatic Vessels in Human Livers With Chronic Hepatitis C - Relation to Histological Variables

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