Avaliação do endométrio em menopausadas após uso de isoflavonas

Wolff, Luis Paulo Galvão; Martins, Marcos Roberto; Bedone, Aloísio José; Monteiro, Ilza

doi:10.1590/s0104-42302006000600022

Cited by 13 publications

(10 citation statements)

References 20 publications

(40 reference statements)

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“…In addition, vaginal dr yness, dyspareunia and urinar y urgency, which are associated with urogenital atrophy, may inter fere with the sex life and quality of life of postmenopausal women 2,3 . Some women also experience cognitive impairment, insomnia, depression, irritability, fatigue, psychological symptoms, and increased risk for osteoporosis and cardiovascular disease 3,4 . To minimize the impact of ovarian failure on women's health, hormone therapy is of ten recommended.…”

Section: Introductionmentioning

confidence: 99%

Efeitos do Trifolium pratense nos sintomas climatéricos e sexuais na pós-menopausa

Giorno¹,

Fonseca²,

Bagnoli³

et al. 2010

Rev. Assoc. Med. Bras.

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objectIve. To evaluate the effects of treatment with Trifolium pratense on climacteric symptoms and sexual satisfaction in postmenopausal women. Methods. This is a prospective, randomized, double-blind, placebo-controlled study. Initially, 120 women aged 45-65 years with menopausal symptoms, more than 12-month amenorrhea and no treatment in the past six months were selected. The participants were then divided into two groups: TG -receiving 40 mg Trifolium pratense, 1 capsule/day; PG -receiving placebo capsules containing lactose (control), 1 capsule/day. The duration of treatment was 12 months. The patients underwent clinical and laboratory evaluation before treatment and at four, eight and 12 months of treatment. The Kupperman Menopausal Index and the Golombok Rust Inventory of Sexual Satisfaction (GRISS) were used. At the end of the study, each group comprised 50 patients. results. According to the Kupperman Menopausal Index, there was significant improvement in menopausal symptoms after four months of treatment, especially in relation to hot flashes, when compared to baseline data in both groups. However, no significant differences were observed between groups. There was no improvement in sexual satisfaction after treatment. conclusIon. A 12-month treatment with a daily dose of 40 mg Trifolium pratense did not yield a significant improvement in menopausal symptoms and sexual satisfaction.

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Section: Introductionmentioning

confidence: 99%

Efeitos do Trifolium pratense nos sintomas climatéricos e sexuais na pós-menopausa

Giorno¹,

Fonseca²,

Bagnoli³

et al. 2010

Rev. Assoc. Med. Bras.

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“…pratense contém fitoestrogênios, que podem ser utilizadas na menopausa. A menopausa se caracteriza pelo aparecimento de sintomas como: fogachos, osteoporose, alterações urogenitais, e distúrbios cognitivos, entre outros (12).…”

Section: Resultsunclassified

“…Em alguns casos, esse fato pode levar ao desenvolvimento de hiperplasia endometrial. Entre as pacientes do estudo, não foi observada uma relação entre o sangramento genital e o estímulo endometrial (12).…”

Section: Resultsunclassified

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Farmacovigilancia De Fitoterápicos Em Uma Indústria Farmacêutica Brasileira: Mecanismo De Aperfeiçoamento Dos Produtos

Abreu

Moura

2014

Infarma

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The use of herbal medicines is based on popular traditions and considered a therapeutic alternative to the use of official medicine. Incorrectly, the use of these medications is considered as exempt from adverse reactions. However, it may cause harmful effects if used with no proper guidance. After been released in the market, drugs may cause unexpected adverse reactions, making necessary pharmacovigilance work. This study aimed to investigate cases of adverse reactions registered for herbal medicines from a Brazilian pharmaceutical industry. Therefore, a descriptive, retrospective, cross-sectional and quantitative study was carried out for a period of eighteen months, through a database of spontaneous reports of unexpected events for herbal medicinnes produced by the mentioned industry. During the evaluation period, thirty-two notifications were registered, distributed among six herbal medicines containing: Trifolium pratense L, Pinus pinaster Aiton, Hedera helix L., Tribullus terrestris L., Pelargonium sidoides DC., Cimicifuga racemosa (L.) Nutt. The most reported adverse reaction, regardless of plant species, was allergy. People above fifty years old were responsible for most reports, originated mainly from Brazilian southeastern region. It was possible to conclude that most herbal medicines produced and distributed by the pharmaceutical laboratory involved in this study can be considered safe and effective for the treatment of diseases which they are designed to. In order to guarantee better contact between the notifier and the prescriber, it is important to disclose pharmacovigilance of herbal medicines among health workers. In this sense, it is possible to know the probable harmful effects, allowing actions to improve the product, ensuring its efficacy and safety.

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“…These women were being treated at the Gynecology department at the Center for Integral Women's Healthcare (CAISM-Unicamp) and had taken part in an endometrial evaluation study. 13 Since these women had not been on hormone therapy in the previous 6 months and did not present with any type of genital bleeding after menopause, they were defined as asymptomatic. All of them initially underwent ultrasound, ambulatory hysteroscopy and endometrial aspiration biopsy using a Pipelle suction curette, performed by a single observer.…”

Section: Methodsmentioning

confidence: 99%