Avaliação de soluções antifúngicas de guanidina para resina base de dentadura: um estudo in vitro

Abstract

Background: The purposes of this study were: (1) to formulate polyhexamethylene guanidine hydrochloride (PHMGH) solutions at different concentrations; (2) to evaluate their antifungal activity against a mature biofilm of Candida albicans on acrylic resins; (3) to evaluate possible effects on acrylic resins flexural strength and surface roughness. Methods: PHMGH solutions were formulated with distilled water and 0.125, 0.250, or 0.5 wt.% of PHMGH. One group without PHMGH was used as control. For antifungal activity analysis, acrylic resin specimens were contaminated with C. albicans. Specimens were immersed in PHMGH solutions or distilled water for 5 or 10 min. Ultimate flexural strength and surface roughness of acrylic resins were evaluated. Results: All PHMGH solutions at 5 or 10 min showed antifungal activity compared to the control group (p

Biomaterials for the Prevention of Oral Candidiasis Development

“…Guanidines are another class of cationic polymers that can be used as antiseptics and antimicrobials. Particularly, polyhexamethylene guanidine hydrochloride (PHMGH) was evaluated for its antifungal properties [61,[64][65][66]. Choi et al [67] reported a more potent antifungal activity of PHMGH than amphotericin B, with no hemolytic and lactate dehydrogenase release activities.…”