Avaliação de dislipidemia e de índices antropométricos em pacientes com Diabetes Mellitus tipo 1

Arcanjo, Christiane Lopes; Piccirillo, Laura J.; Machado, Iara do Vale; Andrade, Carolina Barbosa de; Clemente, Eliete Leão da S.; Gomes, Marília de Brito

doi:10.1590/s0004-27302005000600015

Cited by 15 publications

(12 citation statements)

References 37 publications

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“…However, the prevalence in the present study was much higher than that found by Polak and cols., who reported that 16% of puberal patients with T1D had elevated TC, while 5% had hypertriglyceridemia (15). Regarding the atherogenic profile, the most commonly reported forms of DLP in patients with T1D include elevated TC, LDL, and TG values (4,6,9) which are similar to the findings observed in the present study.…”

Section: Discussionsupporting

confidence: 90%

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Dyslipidemia in young patients with type 1 diabetes mellitus

Homma

Endo

Saruhashi

et al. 2015

Arch. Endocrinol. Metab.

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Objective: The association between type 1 diabetes mellitus (T1D) and dyslipidemia (DLP) increases the risk of cardiovascular disease (CVD). The aim of this study was to evaluate the presence of dyslipidemia in young T1D patients. Materials and methods: The study design was cross-sectional and descriptive. We reviewed medical records of T1D patients followed at an endocrinology service, from 1998-2012. Data collected: gender, actual age and age at diagnosis, duration of T1D since diagnosis, body mass index (BMI), pubertal stage, glycemic control (GC) determined by glycated hemoglobin (HbA1c), total cholesterol (TC), HDL, LDL, triglycerides (TG). To analyze lipid profile and metabolic control, we used the Brazilian Society of Diabetes Guidelines. Results: Were included 239 T1D patients, 136 (56.9%) females; mean ± SD: actual age 15.7 ± 5.0 years and at T1D diagnosis 7.3 ± 3.9; T1D duration 10.6 ± 6.4 years, 86.6% puberty, 15.1% overweight. The prevalence of DLP was 72.5%, 63.3% females, 86.6% puberty, mean ± SD: actual age 15.4 ± 4.8 years and at T1D diagnosis 7.2 ± 4.1 years, duration of T1D 10.7 ± 6.1 years. We found high-CT in 56.7%, low-HDL = 21.7%, high LDL = 44.0%, high-TG = 11.8%. Between females with DLP, 83.5% was in puberty. We find correlation between the presence of DLP, a poor GC and BMC. Conclusion: We found a high prevalence of DLP in young patients with T1D, particularly in puberty females. Programs targeting the prevention of dyslipidemia should be adopted, especially for this group, in order to prevent/delay chronic complications and cardiovascular disease. Arch Endocrinol Metab. 2015;59(3):215-9

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Section: Discussionsupporting

confidence: 90%

“…Changes in lifestyle that contribute to overweight and obesity, including sedentarism and high carbohydrate and fat diets, may have contributed to this increased DLP prevalence (1,4,5).…”

Section: Introductionmentioning

confidence: 99%

Dyslipidemia in young patients with type 1 diabetes mellitus

Homma

Endo

Saruhashi

et al. 2015

Arch. Endocrinol. Metab.

View full text Add to dashboard Cite

show abstract

“…In our study, the analysis of LDL during following five years reported the same finding of from high rate of TC and LDL among pubertal patients with TID. Regarding the atherogenic profile, the most commonly reported forms of DLP in patients with T1D include elevated TC, LDL, and TG values [15] [16] [20], which are similar to the findings observed in the present study. In addition to our study we were studying the same lipid parameters for the same patients for five years and reported the same increasing level.…”

Section: Discussionsupporting

confidence: 90%

Dyslipidemia in Kuwaiti Adolescents with Type 1 Diabetes

Otaibi¹,

Abdul-Rasool²,

Yaiesh³

et al. 2017

JDM

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Objective: Type 1 diabetes mellitus (T1D) and dyslipidemia (DLP) increase the risk of cardiovascular disease (CVD). The objective of this study was to evaluate the progress and perspective of dyslipidemia in young T1D patients . Materials and Methods: The study was cross-sectional and descriptive design. Medical records of T1D patients were followed at an endocrinology service from 2008-2014. The collected data included gender, age, duration of T1D, body mass index (BMI), glycated hemoglobin (HbA1c), total cholesterol (TC), HDL, LDL and triglycerides (TG). Results: 126 T1D patients were recruited: 69 male (54.8%) and 57 female (45.2%) with a mean of age 16.4 (±0.18) and 16.5 (±0.18), respectively. Diabetes duration and baseline HbA1c were 14.82 (±2.11) and 8.68 (±1.21), respectively. The HbA1c (average range of HbA1c 6.5% to 10.7%) increased significantly while following five years by 2.9% (p < 0.001). The prevalence of overweight and obese teens was increasing from the 1st year to the following five years later. In contrast, the underweight and healthy subjects were decreasing for the same subsequent years. Means of HbA1c were significantly higher among overweight and obese categories throughout following years. All lipid profile revealed significant increase during five years follow-up study. The prevalence of risk TC/HDL ratio (< 4.1) gradually raised in the last year follow-up by 52.1% comparing to the baseline risk ratio (0.8%). The study of TC/HDL ratio with BMI categories revealed that average T1D patients had an ideal ratio (n = 97) in the 1st year measurement. After five years follow-up study, the frequency of ideal ratio declined among all categories in the same rate. Risk TC/HDL ratio in the last year of the study showed that average group had more risk ratio measurements (n = 47) in contrast to the 1st year measurement (n = 1). The significant positive correlations were reported between HbA1c and DLP as shown in figure (r2 = 0.85). HbA1c and BMI percentile analyses during long follow-up years were How to cite this paper: Al Otaibi, F., Abdul-Rasool, M., Yaiesh, R. and Al Otaibi, N. 97very highly significant differences (p < 0.0001) between the categories BMI in each year and from one year to another. Conclusion: Attention must be given to control DLP and other comorbidities among T1D adolescents to decrease diabetes macrovascular and microvascular complications.

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“…As avaliações de IMC descritas por outros autores (13) são semelhantes às deste estudo, sendo que a prevalência de sobrepeso e obesidade em crianças e adolescentes com DM1 foi de 13,8% e 3%, respectivamente. Houve associação significativa e inversa entre o IMC e a escala de satisfação da QV, o que foi relacionado a pior QV em uma pesquisa multicêntrica (14) . Seguindo-se os critérios propostos pela I Diretriz Brasileira Sobre Prevenção da Aterosclerose em Crianças e Adolescentes (15) , Como se sabe, as dificuldades apresentadas pelos pacientes portadores de DM1 para a obtenção de um bom controle metabólico estão relacionadas à sua adesão a um plano alimentar, ao incremento da atividade física e ao seguimento da terapêutica medicamentosa.…”

Section: Resultsunclassified