Avaliação da relação neutrófilos/linfócitos em pacientes com suspeita de síndrome coronariana aguda

Zazula, Ana Denise; Précoma-Neto, Daniel; Gomes, Aline Maria; Kruklis, Heidi; Barbieri, Giovano Franco; Forte, Rafael Yared; Langowiski, André Ribeiro; Facin, G; Souza, Luiz César Guarita; Faria-Neto, José Rocha

doi:10.1590/s0066-782x2008000100006

Cited by 30 publications

(9 citation statements)

References 18 publications

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“…In addition, recent studies have shown that patients with CAD have increased platelet and monocyte aggregates in their bloodstream, which was associated with plaque instability, worse in-hospital outcomes, and increased risk of future cardiac events [ 21 , 22 ]. On the other hand, elevated numbers of lymphocytes have also been speculated to be related to an increase in plaque stability [ 23 ]. Previous studies reported that lymphocytopenia was independently related to mechanical complications and mortality in patients with acute myocardial infarction [ 24 , 25 ].…”

Section: Discussionmentioning

confidence: 99%

Platelet/lymphocyte ratio was associated with impaired myocardial perfusion and both in-hospital and long-term adverse outcome in patients with ST-segment elevation acute myocardial infarction undergoing primary coronary intervention

Toprak¹,

Tabakçı²,

Şimşek³

et al. 2015

pwki

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IntroductionPlatelet/lymphocyte ratio (PLR) has been shown to be an inflammatory and thrombotic biomarker for coronary heart disease, but its prognostic value in ST-segment elevation myocardial infarction (STEMI) has not been fully investigated.AimTo investigate the relationship between PLR and no-reflow, along with the in-hospital and long-term outcomes in patients with STEMI.Material and methodsIn the present study, we included 304 consecutive patients suffering from STEMI who underwent primary percutaneous coronary intervention (p-PCI). Patients were stratified according to PLR tertiles based on the blood samples obtained in the emergency room upon admission. No-reflow after p-PCI was defined as a coronary thrombolysis in myocardial infarction (TIMI) flow grade ≤ 2 after vessel recanalization, or TIMI flow grade 3 together with a final myocardial blush grade (MBG) < 2.ResultsThe mean follow-up period was 24 months (range: 22–26 months). The number of patients characterized with no-reflow was counted to depict increments throughout successive PLR tertiles (14% vs. 20% vs. 45%, p < 0.001). In-hospital major adverse cardiovascular events and death increased as the PLR increased (p < 0.001, p < 0.001). Long-term MACE and death also increased as the PLR increased (p < 0.001, p < 0.001). Multivariable logistic regression analysis revealed that PLR remained an independent predictor for both in-hospital (OR = 1.01, 95% CI: 1.00–1.01; p = 0.002) and major long-term (OR = 1.01, 95% CI: 1.00–1.01; p < 0.001) adverse cardiac events.ConclusionsPlatelet/lymphocyte ratio on admission is a strong and independent predictor of both the no-reflow phenomenon and long-term prognosis following p-PCI in patients with STEMI.

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Section: Discussionmentioning

confidence: 99%

Platelet/lymphocyte ratio was associated with impaired myocardial perfusion and both in-hospital and long-term adverse outcome in patients with ST-segment elevation acute myocardial infarction undergoing primary coronary intervention

Toprak¹,

Tabakçı²,

Şimşek³

et al. 2015

pwki

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“…Glucorticoids secreted in stress act to increase the number and percentage of neutrophils while decreasing the number and percentage of lymphocytes (Johnstone et al 2012 ). Thus, neutrophil:lymphocyte ratio is of diagnostic value in stress (Altan et al 2003 ; Walsh et al 2005 ; Zazula et al 2008 ).…”

Section: Haematological Responses To Stress Factorsmentioning

confidence: 99%

Effect of age, sex, physical activity and meteorological factors on haematological parameters of donkeys (Equus asinus)

et al. 2014

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The review examines the role of blood in homeostasis, diagnosis and treatment of disease as influenced by meteorological stress factors, age, sex and physical activity of the donkeys. Haematological parameters play a crucial role in clinical diagnosis of infectious and parasitic diseases, in assessing the responses of donkeys to treatment and in prevention of diseases. The changes in blood values are important in evaluating the responses of the animals to various physiologic conditions. In conclusion, haematological values of donkeys are largely influenced by age, sex, physical factors of the environment and physical activity, and consideration of the factors will aid accurate diagnosis and therapeutic evaluation of equine diseases.

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“…In countries with limited resources, both NLR and PLR are relatively easy, quick, and inexpensive tools that have the potential for both diagnosis and risk stratification of patients admitted with acute chest pain [7].…”

Section: Introductionmentioning

confidence: 99%

The Role of the Platelet/Lymphocyte Ratio and Neutrophil/Lymphocyte Ratio in Predicting High-Risk Heart Score in Patients Admitted with Non-ST Elevation Acute Coronary Syndrome

Seaoud

Mohamed

Elkot

2020

Pulse

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Background: For cardiologists, management of acute chest pain continues to be a challenge. Physicians struggle to avoid unnecessary admissions and at the same time not to miss highrisk patients needing urgent intervention. Therefore, diagnostic strategies focus on identifying patients in whom an acute coronary syndrome can be safely ruled out based on findings from history, physical examination, and early cardiac marker measurement. The HEART score, a clinical prediction rule, was developed to provide the clinician with a simple and reliable predictor of cardiac risk. Aim: This study aimed to investigate the role of neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) as independent laboratory biomarkers when associated with the HEART risk score. Method: A cross-sectional study of 120 patients who attended the emergency department with acute chest pain. NLR and PLR were both measured. In addition, the HEART score was the valid instrument used in evaluating and risk stratifying patients into low-, intermediate-, and high-risk group. Results: There was a positive correlation between the HEART score and the mean PLR and NLR (p = 0.000*). PLR and NLR were found to be significantly higher in the high-risk HEART score group (p = 0.05 and 0.0001*, respectively). A PLR of 115.5 and above had a sensitivity of 73% and specificity of 78%, while an NLR of 3.95 and above had a sensitivity of 75% and specificity of 86% to detect high-risk HEART score patients. Conclusion: PLR and NLR proved to be a useful tool to identify highrisk patients when validated against the HEART score.

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Avaliação da relação neutrófilos/linfócitos em pacientes com suspeita de síndrome coronariana aguda

Abstract: The N/L ratio presents correlation with final diagnosis of patients with suspicion of ACS at admission. Considering this is a low cost, good reproductibility test, new studies should ellucidate whether the ratio may be of relevance for diagnosis flowcharts currently in use.

Cited by 30 publications

References 18 publications

Platelet/lymphocyte ratio was associated with impaired myocardial perfusion and both in-hospital and long-term adverse outcome in patients with ST-segment elevation acute myocardial infarction undergoing primary coronary intervention

Platelet/lymphocyte ratio was associated with impaired myocardial perfusion and both in-hospital and long-term adverse outcome in patients with ST-segment elevation acute myocardial infarction undergoing primary coronary intervention

Effect of age, sex, physical activity and meteorological factors on haematological parameters of donkeys (Equus asinus)

The Role of the Platelet/Lymphocyte Ratio and Neutrophil/Lymphocyte Ratio in Predicting High-Risk Heart Score in Patients Admitted with Non-ST Elevation Acute Coronary Syndrome

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