Avaliação da relação entre produção plaquetária e expressão de proteínas do sistema apoptótico plaquetário em diferentes graus de plaquetopenia da Trombocitopenia Imune (PTI)

Barros, Francisco Erivaldo Vidal

doi:10.11606/t.5.2015.tde-31032015-163547

Cited by 1 publication

(1 citation statement)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In agreement with that, IFN-γ-deficient mice are more susceptible to DENV2 and DENV3 infection ( 36 , 37 ). It has been previously reported that lower levels of PDGF are observed in thrombocytopenic DENV patients, suggesting the relevant role of this growth factor in the pathogenesis of DENV ( 38 ). Overall, together with previous reports, our data suggest that the profile of CXCL10, IL-6, IFN-γ and PDGF may represent a useful set of biomarkers to monitor DENV outcome caused by distinct serotypes with a putative prognostic purpose.…”

Section: Discussionmentioning

confidence: 95%

Serum Soluble Mediator Profiles and Networks During Acute Infection With Distinct DENV Serotypes

et al. 2022

View full text Add to dashboard Cite

A panoramic analysis of chemokines, pro-inflammatory/regulatory cytokines, and growth factors was performed in serum samples from patients with acute DENV infection (n=317) by a high-throughput microbeads array. Most soluble mediators analyzed were increased in DENV patients regardless of the DENV serotype. The substantial increase (≥10-fold) of CXCL10, IL-6, and IFN-γ, and decreased levels of PDGF (<0.4-fold) was universally identified in all DENV serotypes. Of note, increased levels of CXCL8, CCL4, and IL-12 (≥3-9-fold) were selectively observed in DENV2 as compared to DENV1 and DENV4. Heatmap and biomarker signatures further illustrated the massive release of soluble mediators observed in DENV patients, confirming the marked increase of several soluble mediators in DENV2. Integrative correlation matrices and networks showed that DENV infection exhibited higher connectivity among soluble mediators. Of note, DENV2 displayed a more complex network, with higher connectivity involving a higher number of soluble mediators. The timeline kinetics (Day 0-1, D2, D3, D4-6) analysis additionally demonstrated differences among DENV serotypes. While DENV1 triggers a progressive increase of soluble mediators towards D3 and with a decline at D4-6, DENV2 and DENV4 develop with a progressive increase towards D4-6 with an early plateau observed in DENV4. Overall, our results provided a comprehensive overview of the immune response elicited by DENV infection, revealing that infection with distinct DENV serotypes causes distinct profiles, rhythms, and dynamic network connectivity of soluble mediators. Altogether, these findings may provide novel insights to understand the pathogenesis of acute infection with distinct DENV serotypes.

show abstract

Section: Discussionmentioning

confidence: 95%