Avaliação da endotelização de hastes de stents em artérias ilíacas de coelhos

Takimura, Celso Kiyochi; Watanabe, Ii-sei; Laurindo, Francisco Rafael Martins; Gutierrez, Paulo Sampaio; Aiello, Vera Demarchi; Morato, S.P.; Neto, Pedro Alves Lemos

doi:10.1590/s0066-782x2012005000103

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“…The Inspiron TM stent has been extensively studied in experimental animals with results comparable to those of other drug-eluting stents as regards safety, stent-strut endothelialization, and neointimal hyperplasia 19,20 .…”

Section: Discussionmentioning

confidence: 99%

Preclinical Study of a Biodegradable Polymer-based Stent with Abluminal Sirolimus Release

Takimura

Campos

Melo

et al. 2014

Arquivos Brasileiros De Cardiologia

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BackgroundBioabsorbable polymer stents with drug elution only on the abluminal surface may be safer than durable polymer drug-eluting stents.ObjectiveTo report the experimental findings with the InspironTM stent - a bioabsorbable polymer-coated stent with sirolimus release from the abluminal surface only, recently approved for clinical use.Methods45 stents were implanted in the coronary arteries of 15 pigs. On day 28 after implantation, angiographic, intracoronary ultrasonographic and histomorphological data were collected. Five groups were analyzed: Group I (nine bare-metal stents); Group II (nine coated with bioabsorbable polymer on the luminal and abluminal surfaces); Group III (eight stents coated with bioabsorbable polymer on the abluminal surface); Group IV (nine stents with bioabsorbable polymer and sirolimus on the luminal and abluminal surfaces); and Group V (ten stents with bioabsorbable polymer and sirolimus only on the abluminal surface).ResultsThe following results were observed for Groups I, II, III, IV and V, respectively: percentage stenosis of 29 ± 20; 36 ± 14; 33 ± 19; 22 ± 13 and 26 ± 15 (p = 0.443); late lumen loss (in mm) of 1.02 ± 0.60; 1.24 ± 0.48; 1.11 ± 0.54; 0.72 ± 0.44 and 0.78 ± 0.39 (p = 0.253); neointimal area (in mm2) of 2.60 ± 1.99; 2.74 ± 1.51; 2.74 ± 1.30; 1.30 ± 1.14 and 0.97 ± 0.84 (p = 0.001; Groups IV and V versus Groups I, II and III); and percentage neointimal area of 35 ± 25; 38 ± 18; 39 ± 19; 19 ± 18 and 15 ± 12 (p = 0.001; Groups IV and V versus Groups I, II and III). Injury and inflammation scores were low and with no differences between the groups.ConclusionThe InspironTM stent proved to be safe and was able to significantly inhibit the neointimal hyperplasia observed on day 28 after implantation in porcine coronary arteries.

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Section: Discussionmentioning

confidence: 99%