Avaliação Da Correlação De Sorologia E Teste De Ácido Nucleico Em Doadores De Sangue Reagentes Para O Vírus Da Imunodeficiência Humana

DAvila, Thiago Ferreira; Santos, Deborah Veiga; Brietzke, Cristine Blume; Jacociunas, Laura Vicedo

doi:10.4322/2357-9730.86556

Cited by 2 publications

(2 citation statements)

References 15 publications

(22 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the specificities of such tests are lower than those of NATs and false positive results may be generated owing to crossreactivity between different antigens. [32][33][34] This situation could lead to the discarding of many blood bags, 35,36 the loss of eligible donors and deficiency in the supply of blood. 34 The low number of seronegative samples that were NAT+ detected in the present study (n = 16) is similar to other publications and can be attributed to the low specificity of the serological tests used.…”

Section: Discussionmentioning

confidence: 99%

“…Immunoassay screening tests for HIV, HBV and HCV provide good sensitivities and their use has increased the safety of transfusion significantly by detecting the fraction of blood bags that are seropositive. However, the specificities of such tests are lower than those of NATs and false positive results may be generated owing to cross‐reactivity between different antigens 32–34 . This situation could lead to the discarding of many blood bags, 35,36 the loss of eligible donors and deficiency in the supply of blood 34 …”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Prevalence, incidence, risk factors and residual risk associated with viral infections among eligible Brazilian blood donors

Santos,

Rios,

Trindade

et al. 2024

Transfusion Medicine

View full text Add to dashboard Cite

Knowledge regarding the profile of eligible blood donors presenting positive results in laboratory screening is essential for reducing transfusion‐transmitted human immunodeficiency virus (HIV), hepatitis B virus (HBV) and hepatitis C virus (HCV). Our study aimed to evaluate the prevalence, incidence, predictor variables and residual risk (RR) of HIV/HBV/HCV in blood bags donated in Minas Gerais, Brazil. This study analysed data retrieved from the records of a large blood bank relating to donations collected at multiple centres within the period 2012–2018, during which 1 991 120 blood bags were screened using immunoassays and nucleic acid tests (NATs). Multilevel modelling was used to investigate the association between sex, civil status and age group with HIV/HBV/HCV. RR was estimated from the incidence values (restricted to negative and positive tests within the study period) and window periods for infections. The prevalence in first time donors, incidence and RR of HCV (223.73 cases per 100 000; 54.84 per 100 000 persons‐year and 1.6527 per 100 000, respectively) were higher than those of HIV (172.65 cases per 100 000; 28.25 per 100 000 persons‐year and 0.8514 per 100 000) and HBV (168.17 cases per 100 000; 18.54 per 100 000 persons‐year and 0.5588 per 100 000). The odds of acquiring infection were greater in male, single and older donors. Sixteen donors were identified as seronegative and NATs+ during the 7‐year span of the study. Our study has clarified some spatiotemporal trends regarding HIV/HBV/HCV infections in donated blood in Brazil. The results will contribute to the formulation of directives addressed to high‐risk donors.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Prevalence, incidence, risk factors and residual risk associated with viral infections among eligible Brazilian blood donors

Santos,

Rios,

Trindade

et al. 2024

Transfusion Medicine

View full text Add to dashboard Cite

show abstract

Correlation between serology and nucleic acid amplification test in blood donors who are reactive for hepatitis B virus, hepatitis C and human immunodeficiency virus and evaluation of the epidemiological profile of infected people in blood centers in the State of Paraná

Madeira

Silva

Scapini³

et al. 2021

Saudi Pharmaceutical Journal

View full text Add to dashboard Cite

Objectives To compare the results of conventional serological tests and molecular technology (NAT, Nucleic Acid Amplification Test), identify donors in the diagnostic window period, and determine the prevalence of hepatitis B virus (HBV), hepatitis C virus (HCV), and human immunodeficiency virus (HIV) among the samples of blood donors blocked by serological screening. Methods A retrospective cross-sectional study was carried out by analyzing blood donor information contained in the database of 20 blood centers in Paraná, from January 2018 to December 2019. Results A total of 1,496 blood bags were reactive for HBV, HCV, or HIV in serological and/or NAT tests. The 20th Regional Health (RH) Unit had the greatest number of unfit individuals with altered screening for the three infections, with a prevalence of 0.70%. The lowest number of blocked blood donors occurred in the 15th RH, with a prevalence of 0.08%. The highest prevalence of HBV occurred in the 8th RH, with a reagent serology of 0.34% and a positive NAT of 0.17%. For HCV, the prevalence for reagent serology was 0.28%, while that for NAT was 0.02%, which occurred in the 20th RH. For HIV and for NAT, the prevalence of blood donors with positive serology occurred in the 20th RH, at 0.25% and 0.04%, retrospectively. The 13th RH had the highest prevalence of HIV in relation to NAT, that is, conventional serology in concomitance with NAT technology, at 0.07%. During the 2-year period, only 1 reactive donor in the 9th was found for NAT (HBV), in a diagnostic window. Conclusion In Paraná’s blood centers, the inability to donate due to HBV, HCV, and HIV, occurred mainly in initial donors, men, those with >8 years of education, aged 16–45 years, married, and O positive. The most affected regions were located in the west and northwest of Paraná. Most of the results showed a discrepancy between the methodologies used.

show abstract

Avaliação Da Correlação De Sorologia E Teste De Ácido Nucleico Em Doadores De Sangue Reagentes Para O Vírus Da Imunodeficiência Humana

Cited by 2 publications

References 15 publications

Prevalence, incidence, risk factors and residual risk associated with viral infections among eligible Brazilian blood donors

Prevalence, incidence, risk factors and residual risk associated with viral infections among eligible Brazilian blood donors

Correlation between serology and nucleic acid amplification test in blood donors who are reactive for hepatitis B virus, hepatitis C and human immunodeficiency virus and evaluation of the epidemiological profile of infected people in blood centers in the State of Paraná

Contact Info

Product

Resources

About