Avaliação da concentração de monóxido de carbono no ar exalado em tabagistas com DPOC

Chatkin, Gustavo; Chatkin, José Miguel; Aued, Gabriel; Petersen, Guilherme Oliveira; Jeremias, Edna Thais; Thiesen, Flávia Valladão

doi:10.1590/s1806-37132010000300011

Cited by 19 publications

(15 citation statements)

References 16 publications

(22 reference statements)

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“…In current smokers with COPD, it is difficult to discriminate between the amount of increased exhaled CO due to lung oxidative stress and that due to CO contained in cigarette smoke. [50] There was negative correlation between eCO levels in COPD patients and lung function (FEV1 values) and it was statistically significant ( P < 0.01), similar to previous study. [6] However, our results differ from a study that showed no negative correlation between CO levels and lung function.…”

Section: Discussionsupporting

confidence: 89%

Correlation of exhaled carbon monoxide level with disease severity in chronic obstruction pulmonary disease

et al. 2018

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Introduction:Amplification of airway inflammation and its destruction due to oxidative stress is a major step in the pathogenesis of chronic obstruction pulmonary disease (COPD). Exhaled carbon monoxide (eCO) may be quantified to evaluate the airway inflammation and oxidative stress in such patients.Objectives:To assess the disease severity of COPD and treatment response by measuring eCO as a biomarker.Materials and Methods:COPD patients diagnosed according to the global initiative for chronic obstructive lung disease guidelines and healthy individuals as controls were selected. One hundred and fifty patients with COPD and 125 controls were included in the study. Participants were further subdivided on the basis of their smoking habits. Clinical examinations and spirometry were done to diagnose COPD by following the standard protocol. eCO was measured using a piCO + Smokerlyzer (Breath CO Monitor, Bedfont Scientific Ltd., Kent, UK). It was a single-center cross-sectional study.Results:Mean (± standard error of mean) CO levels in ex-smokers with COPD were higher (5.21 ± 1.546 ppm; P < 0.05) than in nonsmoking controls (1.52 ± 0.571 ppm) but were lower than in current smokers with COPD (12.55 ± 4.514 ppm; P < 0.05). eCO levels were higher in current smokers with COPD (12.55 ± 4.514 ppm; P < 0.05) compared to healthy smokers (9.71 ± 5.649). There was a negative correlation between eCO and forced expiratory volume in 1 s (FEV1) in COPD (r = −0.28; P < 0.05). The mean eCO level was decreased (6.291–4.332; P < 0.001) with improvement in lung function (FEV1 38.75%–50.65%: P < 0.05) after treatment with inhaled steroid.Conclusion:Our study concludes that quantification of eCO level in COPD varies with different grades of airway obstruction and to measure the treatment response. Measuring the level of eCO can be used to assess the indirect assessment of airway inflammation, oxidative stress, and severity of airway obstruction in COPD patients.

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Section: Discussionsupporting

confidence: 89%

Correlation of exhaled carbon monoxide level with disease severity in chronic obstruction pulmonary disease

et al. 2018

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“…While it is known that quitting smoking is the only factor that can slow the progression of this disease, there is no evidence that there exists a reversion for the pulmonary impairment that has already began. Approximately 90% of COPD cases are related to smoking, whereas other less common risk factors include occupational exposure and biomass burning (26),(27),(28). The historical finding of a lower prevalence of COPD in the female population is associated with a lower proportion of smokers in this group.…”

Section: Introductionmentioning

confidence: 99%

Airway disease: similarities and differences between asthma, COPD and bronchiectasis

Athanazio¹

2012

Clinics

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Airway diseases are highly prevalent worldwide; however, the prevalence of these diseases is underestimated. Although these diseases present several common characteristics, they have different clinical outcomes. The differentiation between asthma, chronic obstructive pulmonary disease and bronchiectasis in the early stage of disease is extremely important for the adoption of appropriate therapeutic measures. However, because of the high prevalence of these diseases and the common pathophysiological pathways, some patients with different diseases may present with similar symptoms. The objective of this review is to highlight the similarities and differences between these diseases in terms of the risk factors, pathophysiology, symptoms, diagnosis and treatment.

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“…They suggest that multidimensional dyspnea scales should be applied in the evaluation of COPD patients. Chatkin et al93 measured exhaled carbon monoxide (COex) levels in smokers with and without COPD. which did not differ significantly between smokers with COPD and those without, suggesting that there seems to be no major contraindications to their use in smokers with COPD.…”

Section: Introductionmentioning

confidence: 99%

A survey of recently published cardiovascular, hematological and pneumological original articles in the Brazilian scientific press

Patel¹,

Caramelli²,

Gomes³

2011

Clinics

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Recent original scientific contributions published in selected Brazilian periodicals and classifiable under cardiovascular and pulmonary subject categories cover a wide range of sub specialties, both clinical and exprimental. Because they appear in journals with only recently enhanced visibility, we have decided to highlight a number of specific items appeared in four Brazilian journals, because we understand that this is an important subsidy to keep our readership adequately informed. These papers cover extensive sub-areas in both fields.

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Avaliação da concentração de monóxido de carbono no ar exalado em tabagistas com DPOC

Cited by 19 publications

References 16 publications

Correlation of exhaled carbon monoxide level with disease severity in chronic obstruction pulmonary disease

Correlation of exhaled carbon monoxide level with disease severity in chronic obstruction pulmonary disease

Airway disease: similarities and differences between asthma, COPD and bronchiectasis

A survey of recently published cardiovascular, hematological and pneumological original articles in the Brazilian scientific press

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