Avaliação da atividade física na prática de vida diária comparada com o nível de atividade da doença em pacientes acromegálicos: impacto na percepção da qualidade de vida

Abstract

Objective:To evaluate the quality of life and its association with daily physical activity and disease control in acromegalic patients. Subjects and methods: A cross-sectional, case series study, composed of 42 patients recruited from the Neuroendocrinology Unit of the University Hospital of Brasilia. Level of physical activity was accessed by the International Physical Activity Questionnaire (IPAQ 6-short-form), which evaluates the weekly time spent on physical activity of moderate to vigorous intensity in different contexts of life. Quality of life was evaluated by The Medical Outcome Study Questionnaire Short Form (SF-36). Data was compared to growth hormone (GH) and insulin-like growth factor (IGF-1) levels. Students' t test and Fisher test were used, p < 0.05, SPSS 17.0. Results: Twenty--two women, aged 51.33 ± 14.33 and 20 men, aged 46.2 ± 13.18 were evaluated. Arthralgia was present in 83% of cases. In men, the most common sites of pain were the knees (73%), spine (47% lumbar, and 53% thoracic and cervical segments), hands and wrists (40%). Higher scores on SF-36 were observed in patients with intermediate or high levels of physical activity, in the domains social functioning (75 CI 57.3-92.6), general health (75.5 CI 60.4-90.5), mental health (70 CI 57.8-82.1). Conclusions: In this study, the presence and severity of physical disability and pain were not associated with initial GH and IGF-1 levels or time of exposure to GH excess. However, the patients considered controlled, with normal a normal age-adjusted IGF-1, presented higher scores in SF-36, in physical and emotional domains, compared with patients with persistent hypersomatotrophism. These findings suggest benefits of metabolic control in self-reported quality of life. Arq Bras Endocrinol Metab. 2013;57(7):550-7 Keywords Acromegaly; quality of life; functional capacity; activities in daily life RESUMO Objetivo: Avaliar a qualidade de vida e sua associação com a prática de vida diária e controle metabóli-co em pacientes portadores de acromegalia. Sujeitos e métodos: Estudo seccional de série de casos, composto por 42 pacientes recrutados na Unidade de Neuroendocrinologia do Hospital Universitário de Brasília. O nível de atividade física foi estimado pelo Questionário Internacional de Atividade Física (IPAQ-6), que avalia o tempo gasto semanalmente em atividades físicas que variam de intensidade em diferentes contextos de vida. A qualidade de vida foi avaliada pelo questionário SF-36. Os dados obtidos foram comparados aos níveis de hormônio do crescimento (GH) e fator de crescimento semelhante à insulina (IGF-1). Os testes t Students e Fisher foram aplicados e p < 0,05 foram considerados significativos, SPSS 17.0. Resultados: Avaliaram-se 22 mulheres com idades de 51,33 ± 14,33 e 20 homens com idades de 46,2 ±13,18. Artralgia foi relatada em 83% dos pacientes. Em homens, os sítios de dor mais comuns foram os joelhos (73%), coluna vertebral (47% lombar, 53% segmentos torácico e cervical), mãos e quadris (40%). Os maiores escores no SF-36 fo...

Predictors of Quality of Life in Acromegaly: No Consensus on Biochemical Parameters

“…The disease-specific factor hypopituitarism was described to have no significant effect (39, 41, 56, 65), while previous/ongoing treatments could not be associated with QoL in acromegaly [i.e., any treatment of acromegaly (not otherwise specified) (10, 21), surgery vs. somatostatin analogs (57, 65)] and physical activity (33). Other predictors were either not reported, or no consensus was reached on other predictors, such as the demographic factors age and gender, the biochemical parameters GH, IGF1, or biochemical control, and the duration of either disease or remission.…”

"The impact of biochemical control on the quality of life of patients with acromegaly"

“…There is also a tendency to sleep disorders, impaired attention, memory and social isolation (7,8). All these disease-related comorbidities can severely affect the quality of life of acromegaly patients and may lead to psychological sequelae (9)(10)(11)(12)(13)(14).…”