Availability of Vitamin E in the Newborn Infant.

György, Paul; Cogan, Gilbert; Rose, Catharine S.

doi:10.3181/00379727-81-19931

Cited by 78 publications

(12 citation statements)

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“…Hydrogen peroxide hemolysis test was performed ac cording to the method originally described by GYORGY et al (21). In our study, there was noted the moderate significance of the correlation between simultaneous maternal and fetal serum vitamin E levels.…”

Section: Research Subjects and Methodsmentioning

confidence: 80%

Fetal and Maternal Relationship in Serum Vitamin E Level

Mino

Nishino

1973

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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This study was carried out on a correlation between simultaneous mater nal and fetal serum vitamin E levels in 112 mothers and cord blood of their infants at delivery. Among the mothers, 55 were supplemented with vitamin E acetate prior to the delivery. The mean serum vitamin E level in the mother's blood and the cord blood was significantly higher in the vitamin E-supplemented group than in the control group, although the difference in the mean level between the two groups was very small in the cord blood, as compared with the maternal blood. A moderate correlation was noted between the cord blood and the mother's blood (r=0.604, 0.522 and 0.567 for the total number of cases, the vitamin E supplemented group and the control group, respectively). Changes in the incidence of the cases with positive erythrocyte hemolysis test in hydrogen peroxide, which were observed in the vitamin-E supplemented group, as compared with the control group, were statistically not signifi cant.It is well known that tocopherol deficiency may be common in newborn infants, especially in premature infants, which leads to a positive hydrogen per oxide erythrocyte hemolysis test. The administration of tocopherol will reverse this phenomenon (1-7). Recently, increased attention has been paid to the role of tocopherol deficiency in the etiology of disorders in the newborn, such as anemia, hemolysis (7-13), edema (7), sclerema (14) and pulmonary injuries result ing from long-term use of therapeutic oxygen of high concentration (15, 16). Many reports indicate that the low serum vitamin E level in the newborn infants is not related to the mother's nutritional status (4, 17), and suggest that it is pro bably due to impaired transport of tocopherol across the placenta. On the other hand, there is a different view concerning the relationship between vitamin E status in newborn infants and that of mothers (18,19). MINK0WSKI et al. (18) showed that the plasma vitamin E level of the infant at birth could be influenced

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Section: Research Subjects and Methodsmentioning

confidence: 80%

Fetal and Maternal Relationship in Serum Vitamin E Level

Mino

Nishino

1973

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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show abstract

“…The hydrogen peroxide hemolysis test was modified from a method reported by ROSE and GYORGY (10,11). five milliliters of blood was collected with heparin, centrifuged at 3,000 rpm for 10 minutes and the serum was used for tocopherol assay.…”

Section: Methodsmentioning

confidence: 99%

Studies on the factors influencing the hydrogen peroxide hemolysis test.

Mind

Nishida

Murata

et al. 1978

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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“…Therefore, it is difficult to explain the fact that three of these patients had normal and two had abnormal peroxide hemolysis on the basis of any alteration of membrane lipid. Although measurement of vitamin E levels was not performed on these patients, it has been shown that virtually all newborns, particularly prematures, have low levels of this vitamin [14]. A direct correlation between low levels of vitamin E and increased susceptibility to peroxide hemolysis in the neonate has not been noted, however [25].…”

Section: Discussionmentioning

confidence: 99%