“…However, little attention has been paid to a possible relation between the HPBF and the total liver flow [4,23]. The functional load is another parameter largely neglected in its significance for both the integrity and regenerative ability of the liver, although on this topic a large body of data has been obtained with the study of auxiliary liver transplantation [7,8,[10][11][12][13]. Finally, unspecific factors provoked by environmental influences, surgical trauma, and stress, respectively, have also been reported to interfere with the normal hepatic potentialities [2,18,25,27].…”